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30% lincomycin hydrochloride injection and preparation method thereof

A technology of lincomycin hydrochloride and injection, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery to achieve the effect of ensuring drug efficacy and increasing bactericidal effect.

Inactive Publication Date: 2017-08-11
上海公谊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One of the technical problems to be solved by the present invention is to provide a 30% lincomycin hydrochloride injection for the shortcomings of the existing lincomycin hydrochloride

Method used

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  • 30% lincomycin hydrochloride injection and preparation method thereof
  • 30% lincomycin hydrochloride injection and preparation method thereof
  • 30% lincomycin hydrochloride injection and preparation method thereof

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Embodiment Construction

[0011] The technical solutions of the present invention will be described in detail below in conjunction with specific embodiments, but the following embodiments are only illustrations of the present invention and will not limit the claims.

[0012] A kind of 30% lincomycin hydrochloride injection of the present invention, it uses C 18 h 34 N 2 o 6 S meter, 10ml: 3g, its pH value is 3.5-5.

[0013] The preparation method of above-mentioned 30% lincomycin hydrochloride injection, it first takes the water for injection of 50% of prescription quantity, adds the benzyl alcohol of prescription quantity and stirs to dissolve, then adds the prescription quantity of lincomycin hydrochloride to dissolve, adds water for injection To the total amount, fine filter with a 0.22um filter element, and sterilize with circulating steam at 100°C for 30 minutes to obtain.

[0014] Stability study

[0015] 1. Strong light effect test

[0016] Get the 30% lincomycin hydrochloride injection of...

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Abstract

The invention discloses 30% lincomycin hydrochloride injection. The ratio of the 30% lincomycin hydrochloride injection by C18H34N2O6S is 10ml:3g. A preparation method of the 30% lincomycin hydrochloride injection includes the steps: adding water for injection accounting for 50% of prescription dosage; adding benzyl alcohol with the prescription dosage; stirring and dissolving the benzyl alcohol; adding lincomycin hydrochloride with the prescription dosage; dissolving the lincomycin hydrochloride; replenishing the water for injection to reach total quantity; performing fine filtration with a 0.22 micrometer filter element; sterilizing solution by circulating steam at the temperature of 100 DEG C to obtain the 30% lincomycin hydrochloride injection. The 30% lincomycin hydrochloride injection is a bacteriostatic agent and has a bactericidal effect on highly sensitive bacteria when at high concentration. By increasing the concentration, the bactericidal effect of lincomycin on the sensitive bacteria is remarkably enhanced. Asepsis of a medicine is ensured by a final bactericidal production process without affecting stability of the medicine, and efficacy is ensured. Clinically, the 30% lincomycin hydrochloride injection is commonly used for gram positive bacterial infection, particularly, infection of penicillin-resistant bacteria sensitive to the lincomycin such as staphylocosis, streptococcicosis and mastitis, and can also be used for swine treponematosis and swine enzootic pneumonia caused by mycoplasma infection.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparation, in particular to 30% lincomycin hydrochloride injection and a preparation method thereof. Background technique [0002] Lincomycin (lincomycin), also known as lincomycin, is a lincosamine-type alkaline antibiotic obtained from the culture medium of Streptomyces. In 1967, it was used to treat diseases of dogs and cats. In 1970 and 1976, it was used as a growth-promoting feed additive for chickens and pigs. In 1979, lincomycin injection began to be used to treat diseases of pigs (Jim, 2009). The mechanism of action of lincomycin is to bind to the ribosomal 50S subunit of sensitive bacteria, inhibit the reaction of peptidyl transferase, block the formation of peptidyl linkages and mRNA displacement, inhibit bacterial protein synthesis, and produce inhibitory or killing effects on bacteria. Lincomycin is effective against most Gram-positive bacteria such as Staphylococcus aureus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7056A61P31/04A61P11/06A61P15/14
CPCA61K9/0019A61K9/08A61K31/7056
Inventor 廖雪玲徐玉明
Owner 上海公谊药业有限公司
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