Multi-channel polypeptide solid-phase synthesis device

Abstract

The invention discloses a multi-channel polypeptide solid-phase synthesis device which comprises a reaction cylinder, wherein a suction filtration connecting pipe and a nitrogen connecting pipe are connected to the bottom of the reaction cylinder, the nitrogen connecting pipe is connected to a nitrogen hose, a nitrogen valve is arranged on the nitrogen connecting pipe, and a suction filtration valve is arranged on the suction filtration connecting pipe; the suction filtration connecting pipe is connected to a vacuumizing hose; a gas in-out pipe is arranged at the top of the reaction cylinder, a plurality of connecting ground openings are connected to the top surface of the reaction cylinder, a polypeptide synthesis pipe is inserted into each of the connecting ground openings, and the bottom end of the polypeptide synthesis pipe is inserted into the lower portion of the reaction cylinder and is provided with a sand core filter element; and a frosted connecting portion is arranged in the middle of the polypeptide synthesis pipe. By inserting different polypeptide synthesis pipes into the same reaction cylinder at the same time for batch reactions, compared with the prior art, the polypeptide solid phase synthesis efficiency is greatly increased, the corresponding research time is shortened, and various derived peptides can be quickly synthesized.

Description

technical field [0001] The invention relates to a chemical experiment device, in particular to a polypeptide solid-phase synthesis device. Background technique [0002] Polypeptide solid-phase synthesis is to connect the protected amino acid to a solid resin, remove the protective group, then react the next protected amino acid with the residue of the first amino acid and form a peptide bond, and then remove the protective group of the second amino acid group, and then connect to the next amino acid, so that the cycle continues to increase the length of the peptide chain. In the solid-phase synthesis of polypeptides, solid resin is the necessary reaction substrate. [0003] In the polypeptide solid-phase synthesis reaction, a suction filtration device is required, and the suction filtration device includes a suction filtration bottle and a vacuum pump connected with the suction filtration bottle. [0004] In the solid-phase synthesis of polypeptides, the reaction solution ...

AI Technical Summary

Problems solved by technology

When preparing multiple derivative peptides based on one parent peptide, most of the coupling solutions required for various derivative peptides are the same, but the current solid-phase peptide synthesis equipment requires the same coupling solution for the preparation of each derivative peptide. Coupling reactions are performed separately when preparing different derivative peptides, and there is a lack of devices and methods that can perform peptide solid-phase synthesis reactions in batches

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