Partially grafted chitosan oligosaccharide surfactant and preparation method
A technology of surfactant and chitosan oligosaccharide, applied in the field of surfactant production, can solve problems such as weak film formation, and achieve the effects of mild nature, good biocompatibility and wide application prospects
Active Publication Date: 2017-08-22
YANGZHOU UNIV
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Problems solved by technology
Amino acid surfactants have certain specific effects on certain substances (such as certain metal ions), but their film-forming properties are relatively weak, while chitosan oligosaccharides have good film-forming properties, so if the advantages of the two can be combined together, it is possible to produce a new type of surfactant with unique functions
Method used
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[0025] (1) Add 0.146g (1.0mmol) glutamine to a round bottom flask equipped with a stirring magnet, add appropriate amount of water to dissolve, add 0.152g (1.1mmol) of sodium carbonate, dropwise add 0.331g (1.1mmol) ) Dioxane solution of oleoyl chloride, ice-water bath, stirring, to make it react completely, to obtain N-oleoyl glutamine solution.
[0026] (2) Use 3N hydrochloric acid to adjust the pH of N-oleoylglutamine solution to be neutral, add 0.64g chitosan oligosaccharide, 0.23g EDAC (1-(3-dimethylaminopropyl)-3-ethylcarbodiethylene Amine hydrochloride), reacted at 0°C to room temperature for 24h to obtain a reaction solution of partially grafted N-(N'-oleoyl glutaminyl)-chitooligosaccharide.
[0027] (3) Centrifuge the reaction solution to obtain partially grafted N-(N′-oleoylglutaminyl)-chitooligosaccharide crude product dissolved in 0.2M acid solution, adjust the pH of the solution to neutral and precipitate out, and then use ethanol Repeated extraction and drying t...
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Abstract
The invention provides a partially grafted chitosan oligosaccharide surfactant and a preparation method, and relates to the technical fields of chemical industry and medicine industry. Glutamine and oleoyl chloride are reacted in order to generate N-oleoyl glutamine, N-oleoyl glutamine and and chitosan oligosaccharide are coupled, in order to obtain the partially grafted chitosan oligosaccharide surfactant, that is the partially grafted N-(N'-oleoyl glutamine acyl)-chitosan oligosaccharide surfactant. The product is a green and environmentally friendly surfactant with good biological compatibility, high efficiency, nontoxicity, and adjustable surface activity; and the surfactant has good film forming performance and mild property, except characteristics of common surfactants, the product can be applied to construction of fat-soluble medicament slow release micro bodies.
Description
technical field [0001] The invention relates to the technical field of chemical engineering and medicine, in particular to a production method of a surfactant. Background technique [0002] Due to the excellent application properties of surfactants, they are widely used in industrial production and people's daily life. All along, people have never stopped the development and research of new surfactants. In particular, the development of surfactants with a wide range of raw materials, good biocompatibility and unique functions has always been one of the research hotspots. [0003] Chitosan oligosaccharide, also known as chitosan oligosaccharide and oligochitosan, is a kind of polymer with a degree of polymerization of 2 to 20 obtained by degrading chitosan by special biological enzyme technology (there are also reports of chemical degradation and microwave degradation technology). Among the oligosaccharide products, the molecular weight is ≤3200Da, which is a low molecular ...
Claims
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IPC IPC(8): B01F17/00A61K9/19A61K31/4422A61K47/36C08B37/08C09K23/00
CPCA61K47/34A61K9/19A61K31/4422C08B37/003C09K23/00C09K23/16
Inventor 薛怀国高庆纪肃成谷平
Owner YANGZHOU UNIV