Micro-nanofluidic chip alignment device and micro-nanofluidic chip alignment assembling method

Abstract

The present invention discloses a micro-nanofluidic chip alignment device and a micro-nanofluidic chip alignment assembling method. The device comprises a micro-observation system, a gas path portion vacuum adsorption system and a mechanical alignment regulation system. An assembling method for fixing a substrate and moving a cover plate is employed to build the alignment device, the substrate is fixed in a culture dish through four pairs of magnets, the cover plate is absorbed by a vacuum chuck and hanged, a manual rotation micromotion device and a manual three-dimensional micromotion device are regulated to realize the movement operation of the cover plate, and an inverted fluorescence microscope is employed to perform real-time observation and alignment state. The micro-nanofluidic chip alignment device and the micro-nanofluidic chip alignment assembling method solve the problem of the three-dimensional movement and angle rotation integration operation of the micro-nanofluidic chip to realize the accurate alignment of chips and satisfy the alignment operation of chips of increasingly becoming complex.

Description

Alignment device and assembly method for a micro-nanofluidic chip technical field The invention belongs to the field of alignment and assembly of micro-nano devices, and relates to an alignment device and an assembly method of a micro-nano fluidic chip, and is suitable for a three-dimensional mobile platform, a rotary movement device and a vacuum adsorption device. Background technique Microfluidic chip, also known as lab-on-a-chip, is a technology characterized by manipulating fluids in a micron-scale space. Function. It has the advantages of light size, small amount of samples and reagents used, fast reaction speed, a large number of parallel processing and disposable, etc., and can be widely used in petrochemical, medical inspection, processing technology and other fields. At present, the use of this chip has not been widely promoted, and the bottleneck restricting its rapid and wide application is the complicated manufacturing and assembly process. There are two type...

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Problems solved by technology

Chinese patent authorization announcement number CN101691203B discloses the name: "A glass micro-nanofluidic chip alignment assembly method and alignment assembly device", its disadvantage is that there is no integrated angle rotation function; Chinese patent authorization announcement number CN205235993U discloses The name is "microfluidic chip alignment and bonding device", and its disadvantage is that it requires multiple precision mobile platforms

In a word, the prior art has the disadvantages of complex structure, few functions, poor precision, etc.

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