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Tissue identification method and biosensor for tissue identification

A technology of biosensors and identification methods, applied in instruments, scientific instruments, measuring devices, etc., can solve problems such as difficult to accurately distinguish between tumor tissue and healthy tissue, increase in the number of operations, and wrongly cut blood vessels, so as to improve efficiency and safety. Good electrical properties and low thermal stability

Active Publication Date: 2019-09-17
王玉麟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, it was often difficult for surgeons to accurately distinguish tumor tissue from healthy tissue during the current operation
However, if you want to send slices for pathological examination during the operation, it will take at least 30 minutes to get the result of tissue identification
In addition, in the prior art, even with the assistance of endoscope and other equipment, the surgeon may still have to make judgments based on clinical experience
As a result, it may be difficult to perform surgery effectively and safely, leading to a decrease in the accuracy of resection of tumor tissue, increasing the possibility of disease recurrence, and adversely affecting the patient's survival rate. It is necessary to perform another operation on the original operation site, which increases the number of operations and causes the patient's burden
[0004] On the other hand, when performing general resection, surgeons may accidentally touch or accidentally cut blood vessels without accurately identifying blood vessels and their surrounding tissues, causing unnecessary bleeding
If the bleeding is serious, it may even endanger the life of the patient and increase the risk of surgical procedures

Method used

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  • Tissue identification method and biosensor for tissue identification
  • Tissue identification method and biosensor for tissue identification
  • Tissue identification method and biosensor for tissue identification

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0052] In order to prove that the tissue identification method proposed by the present invention can effectively, simply and quickly identify and distinguish tissues, the following experiment example is specially made.

[0053] It must be noted that since the process of the tissue identification method has been described in detail above, some details are omitted for convenience of description.

[0054] Detection of biological tissue samples by tissue identification method

example 1

[0056] To prepare the biosensor of the first embodiment above, cut pig skeletal muscle into thin slices with a thickness of about 2.5 mm as a biological tissue sample and place it on the reaction electrode, and press the skeletal muscle sample to make it fully contact with the reaction electrode. Next, apply a pulse voltage V with a pulse width and a pulse height of 50 μs and 0.5 V on the reaction electrode, and measure and calculate the detection current I generated by the transistor within the pulse width to obtain the pulse voltage generated by the skeletal muscle sample. The first sensing index of .

[0057] After obtaining the first sensing index, the skeletal muscle sample was removed, and the biosensor was washed with PBST and deionized water in sequence. Then cut pig fat into thin slices with a thickness of about 2.5mm as a biological tissue sample and place it on the reaction electrode, and press the fat sample to make it fully contact with the reaction electrode. Ne...

example 2

[0064] To prepare the biosensor of the above-mentioned first embodiment, cut pig renal blood vessels into thin slices with a thickness of about 2.5 mm as biological tissue samples and place them on the reaction electrodes, and press the renal blood vessel samples to make them fully contact with the reaction electrodes. Next, apply a pulse voltage V with a pulse width and a pulse height of 50 μs and 0.5 V to the reaction electrode, and measure and calculate the detection current I generated by the transistor within the pulse width to obtain the pulse voltage generated by the renal blood vessel sample. The first sensing index of .

[0065] After obtaining the first sensing index, the renal blood vessel sample was removed, and the biosensor was washed with PBST and deionized water in sequence. Then cut the pig's peripheral muscle of renal blood vessels into thin slices with a thickness of about 2.5mm as a biological tissue sample and place it on the reaction electrode, and press ...

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Abstract

The present invention provides a tissue identification method and a biosensor for tissue identification. The tissue identification method comprises a preparation step and a detection step, wherein the preparation step comprises preparing a biosensor, the biosensor comprises a transistor and a reaction electrode, the reaction electrode is spaced from the transistor relative to the grid terminal of the transistor, and the detection step comprises: placing a biological tissue sample to be identified on the reaction electrode, applying a pulse wave voltage having an adjustable pulse wave width and an adjustable pulse wave height on the reaction electrode to produce pressure difference between the reaction electrode and the grid terminal of the transistor, and measuring and calculating the detection current generated by the transistor in the pulse wave width so as to obtain a first sensing index. The present invention further provides a biosensor for tissue identification. With the tissue identification method and the biosensor of the present invention, the tissue can be effectively, simply and rapidly identified so as to effectively and safely perform surgical medical surgeries.

Description

technical field [0001] The invention relates to a tissue identification method and a biosensor for tissue identification, in particular to a biological tissue identification method and a biosensor for biological tissue identification. Background technique [0002] In the development of medical profession, surgery is one of the important treatment methods, especially in the treatment of tumor or cancer patients, surgical resection of tumor is the most basic and effective treatment method. [0003] More specifically, in the field of medical surgery, tissue site identification is very important for the success rate and safety of surgery. In the past, it was often difficult for surgeons to accurately distinguish tumor tissue from healthy tissue during surgery. However, if a section is to be submitted for pathological examination during the operation, it will take at least 30 minutes to obtain the tissue identification result. In addition, in the prior art, although equipment s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/00
Inventor 王玉麟铭月
Owner 王玉麟