Compound gel preparation for treating radiodermatitis and preparation method thereof

A technology of gel preparation and compound gel, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, skin diseases, etc., can solve the unsatisfactory treatment effect of radiation dermatitis, shorten the course of radiation dermatitis, The low success rate of skin flap transplantation can achieve the effect of promoting wound healing, reducing economic burden and shortening the course of disease

Inactive Publication Date: 2017-09-01
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are certain limitations in the treatment methods of western medicine. The treatment of radiation dermatitis by western medicine is mainly local treatment. Skin flap transplantation, but the success rate of flap transplantation is low due to insufficient basal nutrient supply
[0005] The treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] (1) Preparation of the test product: Take 10 mL of the test product, add pH 7.0 sterile sodium chloride-peptone buffer to 100 mL and mix evenly, as a 1:10 test solution, and dilute it with a diluent to a 1:100 Equivalent dilution levels of the test solution.

[0050] (2) Check:

[0051] ①Take 1mL of the test solution at a ratio of 1:10, and divide it equally into 2 plates, 0.5ml in each plate, and immediately pour the nutrient agar medium into it. After solidification, culture it at 33°C for 3 days, and observe the results daily.

[0052] ②Take 1mL of the test solution at a ratio of 1:10, inject it into a plate, pour rose bengal sodium agar medium into it, and after solidification, culture it at 25°C for 5 days, and observe the results daily.

[0053] ③Take 10mL of the test solution at a ratio of 1:10, add it to 100mL of nutrient broth medium, and incubate at 33°C for 24 hours. The culture was streaked on the mannitol sodium chloride agar medium, cultured at 33°C for ...

Embodiment 1

[0056] Embodiment 1, the compound gel preparation for the treatment of radiation dermatitis

[0057] 1. Formula

[0058] In parts by mass, the formula of the compound gel preparation for treating radiation dermatitis in the present embodiment is as follows:

[0059] 5 parts tetracaine hydrochloride

[0060] 0.5 part hydrocortisone

[0061] 0.5 parts testosterone propionate

[0062] 500 parts cod liver oil

[0063] 7 parts tragacanth gum

[0064] 10 parts sodium sulfacetamide

[0065] 27 parts ethanol

[0066] 450 parts distilled water

[0067] 2. Preparation method

[0068] The preparation process is as follows:

[0069] (1) Dissolve 0.5g of hydrocortisone in 27g of ethanol, add 7g of tragacanth gum to disperse, and stir well.

[0070] (2) Get 5g tetracaine hydrochloride, 10g sodium sulfacetamide and be dissolved in 450g distilled water, add this solution in the solution that above-mentioned step (1) obtains, stir while adding, make it form glue.

[0071] (3) Add 50...

Embodiment 2

[0079] Embodiment 2, the compound gel preparation for the treatment of radiation dermatitis

[0080] 1. Formula

[0081] In parts by mass, the formula of the compound gel preparation for treating radiation dermatitis in the present embodiment is as follows:

[0082] 5 parts lidocaine

[0083] 0.5 part hydrocortisone

[0084] 0.5 parts testosterone propionate

[0085] 500 parts cod liver oil

[0086] 7 parts tragacanth gum

[0087] 10 parts sodium sulfacetamide

[0088] 27 parts ethanol

[0089] 450 parts distilled water

[0090] 2. Preparation method

[0091] The preparation process is as follows:

[0092] (1) Dissolve 0.5g of hydrocortisone in 27g of ethanol, add 7g of tragacanth gum to disperse, and stir well.

[0093] (2) Get 5g lidocaine, 10g sodium sulfacetamide and dissolve in 450g distilled water, add this solution in the solution that above-mentioned step (1) obtains, stir while adding, make it form glue.

[0094] (3) Add 500g cod liver oil and 0.5g testoste...

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Abstract

The invention discloses a compound gel preparation for treating radiodermatitis and a preparation method thereof. The compound gel preparation is prepared from the following components in parts by mass: 1-10 parts of superficial anesthesia, 0.1-1 part of glucocorticoid, 0.1-1 part of androgen, 500 parts of an oil phase, 1.4-14 parts of hydrogel matrix, 2-20 parts of a burn anti-infectious agent, 4-300 parts of alcohol and 200-500 parts of water. The compound gel preparation has an excellent prevention and treatment effect for the radiative skin reaction of tumor patients, has the effects of diminishing inflammation, relieving pain, promoting patient wound healing, nourishing skin, repairing skin injury and the like, can be used for remarkably reliving pains of patients with radiodermatitis, is greatly beneficial to continuous radiotherapy for tumor patients. The medicine is an emulsion which has strong skin affinity, is convenient to use and can be easily removed, and can be used for improving the compliance of patients.

Description

technical field [0001] The invention relates to a compound gel preparation for treating radiation dermatitis and a preparation method thereof. Background technique [0002] At present, the main means of treating tumors include surgery, radiotherapy, and chemotherapy. Radiotherapy plays an important role in tumor treatment, and its clinical application is very extensive. According to statistics, about 60% to 70% of tumor patients will receive radiotherapy at different periods. However, while playing the role of treating tumors, radiation can also cause damage to normal skin tissue, leading to radiation dermatitis. Sexual necrosis and degeneration. If an ulcer is formed, the formation of granulation tissue and vascular network is affected, so the wound is difficult to heal, which may cause long-term infection and deep tissue damage, which will affect the continued radiotherapy. According to statistics, about 87% of patients who receive radiotherapy will have radiation skin r...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/7056A61K31/63A61K47/44A61K47/42A61K47/36A61P17/16A61P17/00A61K31/245A61K31/573A61K31/568A61K31/167A61K31/569
CPCA61K9/06A61K31/167A61K31/245A61K31/568A61K31/569A61K31/573A61K31/63A61K31/7056A61K47/36A61K47/42A61K47/44A61K2300/00
Inventor 赫捷马建辉李国辉戴媛媛陈伟王会凌石亚飞梁军
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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