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Method for preparing phenylacetone from phenylacetic acid

A technology of phenylacetone and phenylacetic acid, applied in the field of preparation of phenylacetone, can solve the problems of low purity of phenylacetone and unreasonable production method of phenylacetone, and achieve the effects of improving reaction, reducing cost and reducing usage amount

Inactive Publication Date: 2017-09-01
王显权
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention intends to provide a method for preparing phenylacetone by using phenylacetic acid, so as to solve the problem that the production method of phenylacetone in the prior art is unreasonable, resulting in low purity of the produced phenylacetone

Method used

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  • Method for preparing phenylacetone from phenylacetic acid
  • Method for preparing phenylacetone from phenylacetic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A method utilizing phenylacetic acid to prepare phenylacetone, comprising the following steps:

[0027] a. Add phenylacetic acid, sodium acetate and acetic anhydride to the enamel reaction kettle in sequence and stir evenly. The molar ratio between sodium and acetic anhydride is 2:1:6;

[0028] b. After stirring phenylacetic acid, sodium acetate and acetic anhydride evenly, put hot oil at 150°C into the jacket of the enamel reaction kettle until acetic acid distills from the top of the distillation tower, and then keep the temperature at the top of the distillation tower at 117°C , use a plastic snake tube to condense the distilled material in the distillation tower and return it to the enamel reaction kettle for 9-11 hours to obtain the reaction liquid;

[0029] c. After the reaction in step b, the reaction solution is heated to distill acetic acid at a temperature of 117° C., and then the temperature is raised to 140° C. to distill acetic anhydride;

[0030] d, cool...

Embodiment 2

[0035] A method utilizing phenylacetic acid to prepare phenylacetone, comprising the following steps:

[0036] a. Add phenylacetic acid, sodium acetate and acetic anhydride to the enamel reaction kettle in sequence and stir evenly. The molar ratio between sodium and acetic anhydride is 2:1:6;

[0037] b. After stirring phenylacetic acid, sodium acetate and acetic anhydride evenly, pour 140°C hot oil into the jacket of the enamel reaction kettle until acetic acid is distilled from the top of the distillation tower, and then keep the temperature at the top of the distillation tower at 120°C , using a plastic snake tube to condense the distilled material in the distillation tower and return it to the enamel reaction kettle for 10 hours to react to obtain a reaction liquid;

[0038] c. After the reaction in step b, the reaction solution is heated to distill acetic acid at a temperature of 120° C., and then the temperature is raised to 140° C. to distill acetic anhydride;

[0039...

Embodiment 3

[0044] A method utilizing phenylacetic acid to prepare phenylacetone, comprising the following steps:

[0045] a. Add phenylacetic acid, sodium acetate and acetic anhydride to the enamel reaction kettle in sequence and stir evenly. The molar ratio between sodium and acetic anhydride is 2:1:6;

[0046] b. After stirring phenylacetic acid, sodium acetate and acetic anhydride evenly, put hot oil at 145°C into the jacket of the enamel reaction kettle until acetic acid is distilled from the top of the distillation tower, and then keep the temperature at the top of the distillation tower at 117°C , use a plastic snake tube to condense the distilled material in the distillation tower and return it to the enamel reaction kettle for 9-11 hours to obtain the reaction liquid;

[0047]c. After the reaction in step b, the reaction solution is heated to distill acetic acid at a temperature of 118° C., and then heated to 145° C. to distill acetic anhydride;

[0048] d, cooling the reaction...

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Abstract

The invention discloses a method for preparing phenylacetone from phenylacetic acid, and belongs to the technical field of preparation of the phenylacetone. The method comprises the following steps: a, adding the phenylacetic acid, sodium acetate and acetic anhydride into an enamel reaction kettle, and uniformly stirring the phenylacetic acid, the sodium acetate and the acetic anhydride; b, heating the enamel reaction kettle till acetic acid is distilled off from the tower top of a distilling tower, and condensing substances, distilled from the distilling tower, through a plastic coiler to enable the substances to flow back into the enamel reaction kettle for reaction, thus obtaining reaction liquid; c, heating the reaction liquid, and distilling out the acetic acid and the acetic anhydride in sequence; d, cooling the reaction liquid to normal temperature, adding water, thus obtaining separation liquid, and performing standing layering on the separation liquid, thus obtaining first oil liquid on the upper layer; e, adjusting the pH value of the first oil liquid to be 12 through a sodium hydroxide solution, and performing alkaline hydrolysis, thus obtaining alkaline hydrolysis liquid; f, standing the alkaline hydrolysis liquid, thus obtaining second oil liquid on the lower layer; g, performing reduced pressure distillation on the second oil liquid, thus obtaining the phenylacetone. According to the method disclosed by the invention, by improvement on a production process of the phenylacetone, the prepared phenylacetone has the characteristics of low cost and high purity.

Description

technical field [0001] The invention belongs to the technical field of preparation of phenylacetone, in particular to a method for preparing phenylacetone from phenylacetic acid. Background technique [0002] Phenylacetone is also called 1-phenyl-2-propanone, the pure product is colorless liquid, b.p.214~216℃(86~87℃ / 13.4kPa), n20D1.516, insoluble in water, soluble in alcohol , ether, benzene, toluene, etc. Phenylacetone is mainly used as an organic intermediate for the synthesis of dimethine sodium salt; as a pharmaceutical intermediate for the synthesis of amphetamine and phenylisopropylamine for the production of choleretic drug cholesterin and antiepileptic drug methine. In addition, it can generate benzoic acid and acetic acid when it reacts with aluminum oxide, it can generate ethyl phenyl carbinol when it reacts with sodium in ethanol, and it can generate propylbenzene when it reacts with zinc plus hydrochloric acid or hydrogen (plus nickel). Given that phenylacetone...

Claims

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Application Information

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IPC IPC(8): C07C45/48C07C45/78C07C49/213
CPCC07C45/48C07C45/78C07C49/213
Inventor 王显权
Owner 王显权
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