Unlock instant, AI-driven research and patent intelligence for your innovation.

Phenolic amide compound II and extraction method and application thereof

A compound, phenolamide technology, applied in the field of traditional Chinese medicine extraction, can solve the problems of extracting phenolamide compounds, the extraction method and use have not yet been reported, etc.

Inactive Publication Date: 2017-09-01
SHENYANG PHARMA UNIVERSITY
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But extract phenolic amide compound II and extraction method and use from pseudophysalis pulp, have not yet been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phenolic amide compound II and extraction method and application thereof
  • Phenolic amide compound II and extraction method and application thereof
  • Phenolic amide compound II and extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The extraction method of phenolic amide compound II is characterized in that comprising the steps:

[0053] (1) With the dry persistent calyx and fruit (4.5kg) of Physalis physalis as raw material, add the volume fraction of 12 mass times of raw material and be 70% ethanol aqueous solution, reflux extraction 2 times, extract 2 hours each time, merge and obtain extract, reduce Pressure reclaims solvent, obtains total extract (550g) after concentrating;

[0054] (2) Disperse the total extract into 5 times by mass of water, extract with sherwood oil and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract (102g);

[0055] (3) The extract from the ethyl acetate layer was separated by silica gel column chromatography, and the dichloride dichlorides with volume ratios of 100:1, 100:2, 100:5, 100:10, 5:1, 2:1 and 1:1 were respectively Gradient elution with methane-methanol as the el...

Embodiment 2

[0073] The extraction method of phenolic amide compound II comprises the steps:

[0074] (1) Using the dried persistent calyx and fruit of Physalis pseudophysalis as raw material, add 80% ethanol aqueous solution with a volume fraction of 8 mass times of the raw material, reflux extraction 3 times, extract for 2 hours each time, combine to obtain the extract, and recover the solvent under reduced pressure, Obtain the total extract after concentration;

[0075] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0076] (3)-(9) are the same as embodiment 1(3)-(9).

Embodiment 3

[0078] The extraction method of phenolic amide compound II comprises the steps:

[0079] (1) Use dried calyx and fruit of pseudophysalis as raw material, add 60% ethanol aqueous solution with a volume fraction of 10 times the mass of the raw material, reflux extraction 3 times, extract 2 hours each time, combine to obtain the extract, recover the solvent under reduced pressure, and concentrate After obtaining the total extract;

[0080] (2) Disperse the total extract into 10 mass times of water, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0081] (3)-(9) are the same as embodiment 1(3)-(9).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for extracting an amide compound II and its application. The compound has a structure of general formula (I); the compound of the present invention and its composition are effective on human neuroblast (SH-SY5Y) cell damage induced by MPP+ It has obvious protective effect, suggesting that the compound of the present invention can be used as a drug for preventing and treating Parkinson's disease, and has good research and development prospects.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction, and relates to a phenolic amide compound II, an extraction method and application. Background technique [0002] Nicandra physaloides (Nicandra physaloides) is an annual herbaceous plant belonging to the family Solanaceae. It is native to Peru. In my country, it is mainly distributed in Yunnan, Guangxi and other places, and it is also cultivated in Guizhou. Pseudophysalis is a kind of Chinese herbal medicine with both medicinal and edible properties. The whole plant has sedative, expectorant, heat-clearing, detoxifying, and cough-relieving effects, and can treat mental illness, rabies, colds, rheumatism, scabies and other diseases. The seeds are used as medicine, called pseudophysalis seeds, which have the effects of clearing heat and annealing, diuretic, expelling wind, and anti-inflammatory, and can treat fever, rheumatoid arthritis, sores, carbuncles, swelling and pain. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C235/34C07C231/24A61K31/165A61P25/16
CPCC07C235/34C07C231/24
Inventor 陈丽霞李华王莉晴高苏钰王莹
Owner SHENYANG PHARMA UNIVERSITY