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Multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment

A technology of heating and pressurizing and chromatographic separation, which is applied in the direction of material separation, analysis materials, measuring devices, etc., can solve the problems of inability to realize method conversion, etc., and achieve the effect of improving sensitivity and reproducibility, and improving diversification

Active Publication Date: 2017-09-01
SHIMADZU (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, various pretreatment methods and separation methods are mostly used independently or offline, and the combination of online pretreatment and separation cannot be realized, let alone the conversion between methods

Method used

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  • Multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment
  • Multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment
  • Multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment

Examples

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Embodiment 1

[0049] Supercritical fluid extraction-reverse phase extraction column trapping-supercritical fluid chromatography online combined analysis mode

[0050] This embodiment provides the supercritical fluid extraction-reversed-phase extraction column trapping-supercritical fluid chromatography online analysis mode of the multifunctional heating and pressurizing extraction-trapping-chromatographic separation online coupling device, which is suitable for For the extraction, enrichment and separation of middle and low polar compounds. In this implementation, the trapping column is a reverse-phase extraction column, the chromatographic column 32 is a reverse-phase chromatographic column dedicated to supercritical fluid, and the heated and pressurized extraction unit 24 is heated and pressurized by introducing liquid carbon dioxide That is to realize carbon dioxide supercritical fluid extraction, the specific analysis steps of the analysis mode are as follows:

[0051] S11: Static extr...

Embodiment 2

[0058] Accelerated solvent extraction-hydrophilic interaction extraction column trapping-hydrophilic interaction chromatography separation online combined analysis mode

[0059] This example provides the accelerated solvent extraction-hydrophilic interaction extraction column capture-hydrophilic interaction chromatographic separation online combined analysis mode of the multifunctional heating and pressure extraction-trapping-chromatographic separation online combination equipment, This mode is suitable for the extraction, enrichment and separation of medium and high polar compounds. In this embodiment, the trapping column 15 is a short chromatographic column for hydrophilic interaction, the chromatographic column 32 is a chromatographic column for hydrophilic interaction, and the heated and pressurized extraction unit 24 only introduces acetonitrile, heated and Accelerated solvent extraction is realized after pressing, and the specific analysis steps of the analysis mode are ...

Embodiment 3

[0067] Supercritical fluid extraction-supercritical fluid chromatography separation analysis mode

[0068] This embodiment provides the supercritical fluid extraction-supercritical fluid chromatography separation analysis mode of the multi-functional heating and pressure extraction-trapping-chromatographic separation online equipment, and the heating and pressure extraction unit 24 is introduced into the liquid Carbon dioxide is heated and pressurized to realize the carbon dioxide supercritical fluid extraction function. see Figure 12, which is a schematic diagram of flow communication in this embodiment. The specific analysis steps of the analysis mode are: the first high-pressure six-way switching valve 11 is in the "1" position, and the pressure of the first back pressure regulator 26 is Set to 10MPa, the pressure of the second back pressure regulator 27 is set to 40MPa; at this time, the second chromatographic pump 21 pushes liquid carbon dioxide, and the third chromatog...

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Abstract

The invention relates to multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment. The multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment comprises four chromatographic pumps, three three-way mixers, two six-way switching valves, a heating pressurized extraction unit, a trapping column, a chromatographic column, a detector and the like. Through combined use of an on-line trapping-desorption-switching device and an extraction-chromatographic separation device, switching of the two high-pressure six-way switching valves and pressure adjustment of a back pressure regulator are controlled, the two extraction modes, including supercritical fluid extraction and accelerated solvent extraction, and the two chromatographic techniques, including supercritical fluid chromatography and high performance liquid chromatography, can be freely combined for use, functional diversity of the equipment is improved, and the multifunctional heating pressurized extraction-trapping-chromatographic separation on-line combined equipment can be effectively used for on-line extraction, trapping, desorption, separation and detection of trace objects in such complicated solid or semi-solid samples as environments, food, medicines and biology.

Description

technical field [0001] The invention belongs to the field of analytical chemical sample pretreatment, and specifically relates to the design, analysis and application of a multi-functional heating and pressure extraction-capture-chromatographic separation on-line equipment, which is suitable for solid or On-line extraction, trapping, desorption, separation and detection of trace organics in semi-solid samples. Background technique [0002] Heating and pressurizing during the extraction process can greatly improve the extraction speed and recovery rate, among which supercritical fluid extraction (supercritical fluid extraction; SFE) and accelerated solvent extraction (Accelerated solvent extraction; ASE) are two common pretreatment extraction techniques . Specifically, SFE usually uses carbon dioxide as a fluid, which can be converted into a supercritical fluid by heating and pressurizing to reach supercritical conditions, which has the advantages of greenness, safety, and h...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72
Inventor 钟启升刘佳琪申玲玲姚劲挺黄涛宏
Owner SHIMADZU (CHINA) CO LTD
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