Medicinal composition for treating Hashimoto's thyroiditis, and preparation method and use thereof

A technology of Hashimoto's thyroiditis, which is applied in the field of pharmaceutical composition and its preparation for the treatment of Hashimoto's thyroiditis, to achieve clear therapeutic effect and process economy

Active Publication Date: 2017-09-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the combined application of Trichosanthes peel and fig for the treatment of Hashimoto’s thyroiditis, let alone the extraction process of mainly extracting Trichosanthes peel and fig, and the application of Trichosanthes peel and fig polysaccharide for the treatment of Hashimoto’s thyroiditis reports of thyroiditis

Method used

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  • Medicinal composition for treating Hashimoto's thyroiditis, and preparation method and use thereof
  • Medicinal composition for treating Hashimoto's thyroiditis, and preparation method and use thereof

Examples

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Effect test

Embodiment 1

[0034] Example 1 The preparation of the polysaccharide extract of Trichosanthes rind and dried fig (1)

[0035] Take 100g of trichosanthes peel and 500g of dried figs, crush them, add 3L of ethyl acetate to soak for 12 hours; discard the organic solvent, add 1.3L of water to the dregs, boil for 2 hours, extract twice, filter and combine Filtrate; use a thin film evaporator to concentrate the water extract to 600ml, set the temperature to 60°C, and use the concentrated solution for later use; add 1.5L of 80% ethanol to the concentrated solution, and let it stand at 25°C to precipitate the crude polysaccharide, and filter to obtain the crude polysaccharide. Cake 8.6g; add 200ml of water to dissolve the filter cake, use the Servage method to deproteinize the crude polysaccharide of the filter cake (32ml chloroform / 8ml n-butanol), after mixing, centrifuge at a speed of 500g for 30min; combine the supernatants; then Dialyze with ordinary cellulose dialysis bags for 24 hours to remo...

Embodiment 2

[0036] The preparation of the polysaccharide extract of embodiment two Trichosanthes bark and dried fig (two)

[0037] Take 100g of Trichosanthes peel and 100g of dried figs, crush them, add 2L of dichloromethane to soak for 24 hours; discard the organic solvent, add 1L of water to the medicinal residue, boil for 3 hours, extract 3 times, filter, and combine the filtrates Concentrate the water extract to 300ml with a thin-film evaporator, set the temperature to 80°C, and use the concentrate for later use; add 1.2L of ethanol to the concentrate, let it stand at 4°C to precipitate the crude polysaccharide, filter to obtain 4.2g of crude polysaccharide filter cake Add 200ml of water to dissolve the filter cake, adopt the Servage method to deproteinize the crude polysaccharide of the filter cake (32ml chloroform / 8ml n-butanol), after mixing, centrifuge at a speed of 1000g, and centrifuge for 60min; merge the supernatant; The cellulose dialysis bag was dialyzed for 48 hours to remo...

Embodiment 3

[0038] Example 3 The preparation of the polysaccharide extract of Fructus Trichosanthes Peel and dried fig (three)

[0039]Take 20g of trichosanthes peel and 400g of dried figs, crush them, add 4.2L of ethanol aqueous solution (80%v / v-90%v / v) to soak for 12 hours; discard the organic solvent, add 1.5L of water to the medicinal residue , boiled and extracted for 4 hours, extracted twice, filtered, and combined filtrate; use a thin film evaporator to concentrate the water extract to 400ml, set the temperature to 75°C, and set the concentrate for use; add 1L of 90% ethanol to the concentrate, and stand at 4°C , make the crude polysaccharide separate out, filter, get the crude polysaccharide filter cake 12.4g; Add 600ml water to dissolve the filter cake, adopt Servage method to carry out deproteinization (96ml chloroform / 24ml n-butanol) to the filter cake crude polysaccharide, after mixing, centrifuge, Rotating speed is 800g, centrifugal 20min; Merge supernatant; Adopt common cell...

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Abstract

The invention belongs to the fields of traditional Chinese medicines and natural medicine pharmaceuticals, and concretely relates to a medicinal composition for treating Hashimoto's thyroiditis, and a preparation method and a use thereof. The medicinal composition for treating Hashimoto's thyroiditis comprises, by weight, 1 part of snakegourd peel and 1-20 parts of dried figs. The snakegourd peel and the dried figs are preferably selected according to the above weight proportions, and are processed through steps to prepare polysaccharide extract, and pharmaceutically-acceptable or health product-acceptable auxiliary materials are added to prepare a conventional oral preparation. A result of experiments of in vivo and in vivo anti-thyroid cancer pharmacological effects of the extract shows that the polysaccharide extract can reduce the high-titer autoantibodiesTGAb and TPOAb of HT, reduce IL-2, increase IL-4, inhibit the hyperthyroidism of Th1 cell functions and promote the drift of Th1 to Th2 in order to alleviate the Hashimoto's thyroiditis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a pharmaceutical composition for treating Hashimoto's thyroiditis, a preparation method and application thereof. Background technique [0002] Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is the most common autoimmune thyroid disease in clinical practice. A disease characterized by the presence of aggressive T lymphocytes and the destruction of follicular structures. In recent years, the incidence of HT has gradually increased, and the onset presents a younger trend. The current clinical treatment for HT hypothyroidism is mainly thyroid hormone replacement therapy, and there is no treatment for the cause. Studies have shown that the imbalance of Th1 / Th2 cell ratio is one of the pathogenesis of this disease. Th1 cells and Th2 cells have different functions, and their positive feedback mechanism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P5/14A61P37/02
CPCA61K36/428A61K36/60A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 吴文爽朱精强苏安平龚艳萍杨建洪
Owner SICHUAN UNIV
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