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Synthesis method of amino acid quaternary amino carboxylate

A kind of technology of quaternary amino carboxylate and synthesis method, applied in the field of compound synthesis

Active Publication Date: 2017-09-15
KUNMING YESHUI BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to overcome the shortcoming of existing synthetic amino acid quaternary amino carboxylate method, a kind of new synthetic method is provided

Method used

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  • Synthesis method of amino acid quaternary amino carboxylate
  • Synthesis method of amino acid quaternary amino carboxylate
  • Synthesis method of amino acid quaternary amino carboxylate

Examples

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Embodiment 1

[0060]Synthesis of DAPC (Proline,5-oxo-,ion(1-),N-decyl-N,N-dimethyl-1-decanaminium(1:1)) Proceed as follows:

[0061] Preparation of solution A: Take 10 mL of absolute ethanol, dissolve 0.0024 mol of KOH in it, heat to 30°C, stir well until KOH is completely dissolved, and obtain solution A;

[0062] Preparation of solution B: Take 10 mL of absolute ethanol, add 0.0024 mol of didecyldimethylammonium chloride into it at room temperature, stir well until the didecyldimethylammonium chloride is completely dissolved, and obtain solution B;

[0063] Preparation of solution C: Mix solution A and solution B at room temperature and stir for 5 minutes to form a precipitate of potassium chloride insoluble in absolute ethanol, fully filter or centrifuge to remove the precipitate of potassium chloride to obtain double decyl dimethyl ammonium hydroxide solution, to obtain solution C;

[0064] Preparation of solution D: Dissolve 0.0024mol of pyroglutamic acid in absolute ethanol to make ...

Embodiment 2

[0069] Synthesis of DAPC (Proline,5-oxo-,ion(1-),N-decyl-N,N-dimethyl-1-decanaminium(1:1)) Proceed as follows:

[0070] Prepare solution A: Take 20 mL of absolute ethanol, dissolve 0.005 mol of KOH in it, heat to 30°C, and stir well until KOH is completely dissolved to obtain solution A;

[0071] Preparation of solution B: Take 15 mL of absolute ethanol, add 0.005 mol of didecyldimethylammonium chloride into it at room temperature, stir well until the didecyldimethylammonium chloride is completely dissolved, and obtain solution B;

[0072] Preparation of solution C: Mix solution A and solution B at room temperature and stir for 5 minutes to form a precipitate of potassium chloride insoluble in absolute ethanol, fully filter or centrifuge to remove the precipitate of potassium chloride to obtain double decyl dimethyl ammonium hydroxide solution, to obtain solution C;

[0073] Preparation of solution D: Dissolve 0.005mol of pyroglutamic acid in absolute ethanol to make a solut...

Embodiment 3

[0078] The synthetic amino acid double-chain quaternary amino carboxylate is double-decyl dimethyl N-acetylalanine ammonium DAAC (1-Decanaminium, N-decyl-N, N-dimethyl-, salt with N-acetylalanine (1:1 ))

[0079] Preparation of solution A: Dissolve 0.0025mol of KOH in absolute ethanol as a solvent, heat to 20°C-30°C, and stir well until KOH is completely dissolved to obtain solution A;

[0080] Prepare solution B: use absolute ethanol as a solvent, add 0.0025mol of didecyldimethylammonium chloride into it at room temperature, stir well until the didecyldimethylammonium chloride is completely dissolved, and obtain solution B ;

[0081] Preparation of solution C: Mix solution A and solution B at room temperature, stir for 1 to 10 minutes, generate potassium chloride precipitate insoluble in absolute ethanol, fully filter or centrifuge to remove potassium chloride precipitate, double decyl dimethyl hydroxide Ammonium solution, to obtain solution C;

[0082] Preparation of solu...

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Abstract

The invention relates to a synthesis method of an amino acid quaternary amino carboxylate, and belongs to the technical field of compound synthesis. The synthesis method comprises: dissolving 1 mole of an alkali metal hydroxide in a volatile organic solvent with a temperature of 20-30 DEG C to obtain a solution A; dissolving 1 mole of double chain quaternary amino ammonium halide or single chain quaternary amino ammonium halide into a volatile organic solvent to obtain a solution B; mixing A and B, and removing insoluble substances to obtain a solution C; dissolving acetylated amino acid in a volatile organic solvent until the obtained solution contains 1 mole of the acetylated amino acid anions so as to obtain a solution D; and mixing C and D, and removing insoluble substances and the volatile organic solvents to obtain the product. According to the present invention, the synthesis steps are simplified, the organic reagents with characteristics of low toxicity, easy recovery and easy treatment are used, and the purity of the amino acid quaternary amino carboxylate is improved.

Description

technical field [0001] The invention belongs to the technical field of compound synthesis, and in particular relates to a synthesis method of amino acid quaternary amino carboxylate. The synthesized product can be used to prevent and treat microbial infection or environment disinfection. Background technique [0002] The Chinese invention patent document with the patent number ZL 201210166719.3 discloses an amino acid quaternary amino carboxylate, including an amino acid single-chain quaternary amino carboxylate and an amino acid double-chain quaternary amino carboxylate, which is composed of negatively charged amino acid anions and does not contain Composed of single-chain or double-chain quaternary amino cations of halogen elements, this compound can kill most pathogenic bacteria or viruses at low concentrations without toxicity. The disclosed synthesis steps of the product are as follows: first step, neutralize the acetylated amino acid with an equivalent amount of metal ...

Claims

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Application Information

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IPC IPC(8): C07D207/28C07C209/00C07C211/63C07C319/20C07C323/59C07C231/12C07C233/47A01P1/00
Inventor 张磊陆可信张峻陆可望
Owner KUNMING YESHUI BIO TECH LTD
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