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Pharmaceutical composition and application thereof in preparation of anti-infective drugs

A composition and anti-infection technology, applied in the field of biomedicine, can solve the problems of uncontrollable emergence and development of drug-resistant bacteria

Inactive Publication Date: 2017-09-26
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although scientists continue to research and manufacture new antibiotics with wider antibacterial spectrum and stronger antibacterial effect, they still cannot control the emergence and development of drug-resistant bacteria

Method used

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  • Pharmaceutical composition and application thereof in preparation of anti-infective drugs
  • Pharmaceutical composition and application thereof in preparation of anti-infective drugs
  • Pharmaceutical composition and application thereof in preparation of anti-infective drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of pharmaceutical composition

[0036] Material: Ginseng, raw astragalus and cinnamon were purchased from Lanzhou Huirentang Pharmaceutical Chain Co., Ltd.

[0037] The pharmaceutical composition (formulation 2) of the present invention includes 2.5 g of ginseng, 7.5 g of raw astragalus, and 1.5 g of cinnamon.

[0038] Preparation:

[0039] The preparation method of the pharmaceutical composition is as follows:

[0040] a. Weigh 2.5g of medicinal materials ginseng, 7.5g of raw astragalus, 1.5g of cinnamon, add 150mL of distilled water, soak for 20min, and boil for 30min;

[0041] b. Stop heating, after cooling, filter out the first decoction liquid;

[0042] c. Add 150 mL of distilled water to the medicine residue obtained in b, and boil for 30 minutes;

[0043] d. Stop heating, after cooling, filter out the second decoction liquid;

[0044] e. Combine the decoction liquid obtained from b and d, and dilute the volume to 50 mL;

[0045] f. Centrifuge the decoction...

Embodiment 2

[0047] Example 2 The in vitro antibacterial effect of the pharmaceutical composition

[0048] 1. Biological materials

[0049] (1) Escherichia coli OP50 (E. coli OP50), purchased from Caenorhabditis Genetics Center (CGC).

[0050] (2) Staphylococcus aureus ATCC 29213 (S. aureus ATCC29213), purchased from the American Culture Collection (ATCC), number 29213.

[0051] (3) Pseudomonas aeruginosa ATCC 27853 (P. aeruginosa ATCC27853) was purchased from the American Culture Collection (ATCC), number 27853.

[0052] (4) Enterococcus faecalis ATCC 29212 (E. faecalis ATCC 29212) was purchased from the American Culture Collection (ATCC), No. 29212.

[0053] (5) Candida Albicans ATCC 10231 (C. albicans ATCC 10231) was purchased from the American Type Culture Collection (ATCC), number 10231.

[0054] 2. Reagent

[0055] (1) Drug: the drug composition prepared in Example 1.

[0056] (2) Composition and production of solid BHI (Brain Heart Infusion) medium (take 1 liter as an example) (BHI medium was pur...

Embodiment 3

[0092] Example 3 The anti-infective effect and side effects of the pharmaceutical composition and its Baoyuan Decoction in vivo

[0093] 1. Biological materials

[0094] (1) C.elegans SS104 was purchased from Caenorhabditis Genetics Center; the genotype is glp-4(bn2)I, which can grow normally in an incubator at a temperature of 20℃, and reproduce offspring, in an incubator at a temperature of 25℃ Growth can induce infertility.

[0095] (2) C.elegans N2 was purchased from Caenorhabditis Genetics Center; it is a wild type and can grow normally in an incubator at a temperature of 20°C and reproduce its offspring.

[0096] (3) Escherichia coli OP50 (E. coli OP50), purchased from Caenorhabditis Genetics Center, as food for C. elegans.

[0097] (4) Enterococcus faecalis OG1RF (E. faecalis OG1RF) was purchased from the American Culture Collection (ATCC), No. 47077.

[0098] (5) Pseudomonas aeruginosa ATCC 27853 (P. aeruginosa ATCC 27853) was purchased from the American Culture Collection (ATCC...

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PUM

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Abstract

The invention discloses a pharmaceutical composition and application thereof in the preparation of anti-infective drugs. The pharmaceutical composition disclosed herein comprises ginseng root, raw membranous / Mongolian milkvetch root and cassiabarktree bark; the pharmaceutical composition disclosed herein is modified vigor-preserving decoction; compared with vigor-preserving decoctions, the pharmaceutical composition of the invention has equivalent in-vivo anti-infective effect and toxic and side effects without containing prepared licorice root. Therefore, compared with the vigor-preserving decoctions, the pharmaceutical composition of the invention is more economical and more applicable in the preparation of drugs for preventing infective diseases.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and relates to a pharmaceutical composition and a preparation method thereof, in particular to the application of the pharmaceutical composition in the preparation of anti-infective drugs. Background technique [0002] With the widespread application and abuse of antibiotics, more and more bacteria have become insensitive to antibiotic drugs, and even have developed severe drug resistance. Although scientists continue to research and manufacture new antibiotics with broader antibacterial spectrum and stronger antibacterial effects, they still cannot control the emergence and development of drug-resistant bacteria. Therefore, it is urgent to find new drugs with antibacterial effects. [0003] The Ausubel laboratory used E. faecalis strains MMH594, OG1RF, OG1RF△fsrB, V583, VS583 to infect wild-type N2 Caenorhabditis elegans (C.elegans) and glp-4 (bn2ts); sek-1( km4) mutant strain nematodes screened 6000 synth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P31/04
CPCA61K9/08A61K36/258A61K36/481A61K36/54A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 李红玉李婵鹤支德娟李洋李莹辉赵晶戴治娟蒋云龙
Owner LANZHOU UNIVERSITY