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Microcapsules comprising lutein or lutein ester

A technology of lutein esters and microcapsules, which is applied in the field of products containing such microcapsules, and can solve the problems of expensive preparation methods and time-consuming preparations

Inactive Publication Date: 2017-09-26
BASF SE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of emulsifiers in the formulation has the disadvantage that air will be trapped in the powder particles and form hollow spheres
In addition, the disadvantage of using emulsifiers is that the preparation method is more expensive and time-consuming, because the emulsifier has to be thoroughly mixed with other ingredients in the water phase and the oil phase respectively

Method used

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  • Microcapsules comprising lutein or lutein ester
  • Microcapsules comprising lutein or lutein ester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] During stirring, 514 g of natural gum arabic, 171 g of sucrose and 18 g of sodium ascorbate were dissolved in 600 g of water at 65°C. During stirring, 180 g of lutein ester concentrate and 17.2 g of mixed tocopherols (70% concentrate) were added, and then homogenized until the lutein ester droplets had an average particle size D of less than 1.0 μm [4;3 ]. Water was used to adjust the viscosity and the dispersion was sprayed into native cornstarch containing silica as flow agent. The formed granules are dried in air at 40-150°C until the moisture content in the powder is below 5%.

[0063] The dry powder obtained had a lutein ester content of 11.3%, which corresponds to 6.08% free lutein as determined by UV / Vis spectroscopy.

Embodiment 2

[0065] In vessel A, 1541 g of natural gum arabic, 382 g of sucrose and 54 g of sodium ascorbate were dissolved in 1800 g of water at 65° C. during stirring. In vessel B, 540 g of lutein ester concentrate were melted together with 137 g of MCT oil and 48.2 g of mixed tocopherols (70% concentrate) at 60-90°C. During stirring, the oil phase from vessel B was added to the water phase in vessel A and then homogenized until the lutein ester droplets had an average particle size D [4; 3] of less than 1.0 μm. Water was used to adjust the viscosity and the dispersion was sprayed into native cornstarch containing silica as flow agent. The formed granules are dried in air at 40-150°C until the moisture content in the powder is below 5%.

[0066] The dry powder obtained had a lutein ester content of 10.9%, which corresponds to 5.87% free lutein as determined by UV / Vis spectroscopy.

Embodiment 3

[0068] In vessel A, 1541 g of natural gum arabic, 382 g of sucrose and 54 g of sodium ascorbate were dissolved in 1800 g of water at 65° C. during stirring. In vessel B, 540 g of lutein esters concentrate were melted together with 137 g of hydrogenated palm oil and 48.2 g of mixed tocopherols (70% concentrate) at 60-90°C. During stirring, the oil phase from vessel B was added to the water phase in vessel A and then homogenized until the lutein ester droplets had an average particle size D [4; 3] of less than 1.0 μm. Water was used to adjust the viscosity and the dispersion was sprayed into native cornstarch containing silica as flow agent. The formed granules are dried in air at 40-150°C until the moisture content in the powder is below 5%.

[0069] The dry powder obtained had a lutein ester content of 12.2%, which corresponds to 6.57% free lutein as determined by UV / Vis spectroscopy.

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Abstract

The invention relates to microcapsules comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising gum acacia and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25 % of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier. The invention further relates to a process of preparing the microcapsule as well as uses and products comprising the microcapsule.

Description

field of invention [0001] The present invention relates to microcapsules comprising lutein or lutein esters as active substance embedded in a hydrocolloid matrix of natural gum arabic, a process for the preparation of such microcapsules and their use and products comprising such microcapsules . Background of the invention [0002] Lutein is a xanthophyll and a naturally occurring carotenoid found in plants such as flowers, especially marigolds, and green leafy vegetables. Lutein, for example, can be extracted from the petals of marigolds, spinach, kale, and broccoli. Calendula is particularly rich in lutein, which is found as lutein esters with fatty acids. Lutein can be used as a yellow pigment in all kinds of compositions such as functional foods and health products, and has well-known pharmacological actions and applications. [0003] Lutein as free lutein has a chemical structure [0004] [0005] Typical lutein esters found in marigold are either mono- or dipalmi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/52A23L2/58A23L5/44A23L33/105A23K20/10A23K20/158A23K20/163A23K20/179A23P10/30A61K9/20A61K9/50
CPCA23K20/158A23K20/163A23K20/179A23K20/10A23L5/44A23L33/105A23P10/30A23L2/52A23L2/58A61K9/2081A61K9/5036A61K9/5089A61K31/047C09B61/00A23L29/25C09B67/0097A61K31/65A61P3/02A23C9/152A23V2002/00
Inventor N·穆萨尤斯I-L·克里博
Owner BASF SE
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