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Preparation method of dopa structure modified chitin tissue repairing material

A technology for tissue repair and dopa structure, applied in coatings, medical science, prostheses, etc., can solve the problems of biomaterials that need to be further improved, achieve low human immunogenicity, enhance cell compatibility, and promote cell Adhesion effect

Inactive Publication Date: 2017-09-29
WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of biomaterials currently used in tissue engineering needs to be further improved, which cannot meet the needs of modern medicine.

Method used

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  • Preparation method of dopa structure modified chitin tissue repairing material
  • Preparation method of dopa structure modified chitin tissue repairing material

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Experimental program
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Effect test

Embodiment 1

[0023] A preparation method of chitin tissue repair material modified by dopa structure, comprising the following steps:

[0024] Step 1: Dissolve 350mg of gelatin in 60mL of water, heat in a water bath to 50°C and stir until completely dissolved to prepare a gelatin solution;

[0025] Step 2: Mix the gelatin solution with 150mg of N-hydroxysuccinimide, 191mg of 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 103mg of dopamine, and place in an electric heating constant temperature water bath at 40°C After stirring for 48 hours, the solution was placed in a dialysis bag, the residual molecular weight of the dialysis bag was 10000Da, the dialysis bag was put into a beaker filled with ultrapure water, the amount of ultrapure water was to overflow the position of the dialysis bag, and Place the beaker in an electric thermostat water tank and stir at 40°C for 2-3 days, and change the ultrapure water every 8 hours;

[0026] Step 3: Take out the solution remaining in the dialysis b...

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Abstract

The invention discloses a preparation method of a dopa structure modified chitin tissue repairing material, and belongs to the field of composite biomaterial preparation. The preparation method comprises the following steps: preparing a dopamine modified solution, preparing a chitin electrospinning membrane and spraying the dopamine modified solution. The dopa structure modified chitin tissue repairing material prepared by the method further improves the cell adhesion and bioactivity of the tissue repairing material.

Description

technical field [0001] The invention belongs to the field of preparation of composite biological materials, and in particular relates to a preparation method of a dopa structure-modified chitin tissue repair material. Background technique [0002] The development of biomaterials has gone through three main stages so far. Since the 1980s, biomedical materials for the purpose of medical treatment, health care and improving the quality of life have achieved rapid development. More than 50 kinds of implanted devices have been used clinically, generally derived from technically mature engineering materials, and It has biocompatibility and defective tissue replacement function, such as heart artificial blood vessels, artificial joints and artificial kidneys that have been widely used in clinical practice. The above-mentioned biomedical materials have a general commonality: biological inertness. That is, the principle followed in the development of biomedical materials is to mini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/50A61L27/34A61L27/20A61L27/54A61L27/58
CPCA61L27/28A61L27/20A61L27/34A61L27/50A61L27/54A61L27/58A61L2300/232A61L2300/42C08L89/00C08L5/08
Inventor 吴长应
Owner WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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