Vonoprazan fumarate pharmaceutical composition

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems of reducing productivity, affecting the final appearance of film-coated tablets, etc., and achieving the effect of excellent storage stability
CN107224438AActive Publication Date: 2017-10-03JIANGSU HANSOH PHARMA CO LTD
5 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU HANSOH PHARMA CO LTD
Publication Date
2017-10-03

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a vonoprazan fumarate pharmaceutical composition; and the invention provides the pharmaceutical composition which contains vonoprazan fumarate as an active ingredient and a method for stabilizing the pharmaceutical composition. Specifically, the pharmaceutical composition containing the vonoprazan fumarate is free from a plasticizer; the pharmaceutical composition is excellent in preparation stability; and the pharmaceutical composition shows excellent stability in a high-temperature environment and during an illuminating phase.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, specifically, a stable pharmaceutical composition containing vonoprazan fumarate and excipients, and a stabilization method thereof. The pharmaceutical composition of the invention is used for treating and maintaining non-erosive gastroesophageal reflux disease, duodenal ulcer, gastric ulcer, erosive esophagitis and other acid-related diseases. Background technique

[0002] Vonoprazan fumarate (Formula I), the chemical name is 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N -Methylmethylamine fumarate, which belongs to a new type of PPI-potassium ion competitive acid blockers (Potassium-competitive acid blockers, P-CAB), through competitive inhibition of hydrogen ion / potassium ion-ATPase It is a reversible potassium ion antagonist. Compared with the traditional PPI, the acid-suppressing effect of vonoprazan fumarate has nothing to do with the activation of the proton ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More