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Use of NUMB in diagnosis or prognosis of primary osteoporosis of postmenopausal women

A technology for osteoporosis and primary osteoporosis, which is applied in the field of prognosis prediction and diagnosis of primary osteoporosis in postmenopausal women, and can solve the problems of high price, small number of equipment, and large economic burden of osteoporosis patients

Inactive Publication Date: 2017-10-03
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is currently only used for the calcaneus, tibia and phalanges, and cannot detect the whole body bones
[0016] Dual-energy X-ray absorptiometry: It is the most ideal measurement method at present, and it is the gold standard for diagnosing osteoporosis. Expensive and therefore financially burdensome for diagnosis in osteoporosis patients

Method used

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  • Use of NUMB in diagnosis or prognosis of primary osteoporosis of postmenopausal women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Screening of genes differentially expressed in postmenopausal women with primary osteoporosis and normal postmenopausal women

[0060] 1. Research object:

[0061] Three postmenopausal women with primary osteoporosis, aged 81, 68, and 79 years old, and two normal postmenopausal women, aged 67 and 68, were selected.

[0062] Inclusion criteria for postmenopausal women with primary osteoporosis: Han postmenopausal women who have menopause for more than 12 months, and all patients have informed consent;

[0063]Exclusion criteria for patients with primary osteoporosis in postmenopausal women include ① Previously received anti-resorptive drugs (including calcitonin, bisphosphonates, estrogen, etc.) or bone-promoting drugs (such as parathyroid hormone, etc.) Treatment (except for those who simply use calcium and / or vitamin D); ② long-term use of glucocorticoids; ③ combined with malignant tumors, bone metastases, and other endocrine and bone metabolism history (suc...

Embodiment 2

[0092] Example 2 QPCR experiment verification of genes differentially expressed in postmenopausal women with primary osteoporosis and normal menopausal women

[0093] The NUMB genes screened out in Example 1 were selected for large sample verification.

[0094] 1. Research object:

[0095] Select 30 postmenopausal women with primary osteoporosis and 30 normal postmenopausal women, aged 65-82 years.

[0096] Inclusion criteria for postmenopausal women with primary osteoporosis: Han postmenopausal women who have menopause for more than 12 months, and all patients have informed consent;

[0097] Exclusion criteria for patients with primary osteoporosis in postmenopausal women include ① Previously received anti-resorptive drugs (including calcitonin, bisphosphonates, estrogen, etc.) or bone-promoting drugs (such as parathyroid hormone, etc.) Treatment (except for those who simply use calcium and / or vitamin D); ② long-term use of glucocorticoids; ③ combined with malignant tumors,...

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Abstract

The invention discloses a use of NUMB in diagnosis or prognosis of primary osteoporosis of postmenopausal women. The detection result shows that the expression of NUMB in the blood of a normal postmenopausal woman is different from the expression of NUMB in the blood of a postmenopausal woman having primary osteoporosis. Based on the correlation between NUMB and primary osteoporosis of postmenopausal women, NUMB is used as a molecular marker for diagnosis and prognosis of primary osteoporosis of postmenopausal women. The molecular marker for a noninvasive method for diagnosis and prognosis of primary osteoporosis of postmenopausal women has a wide clinical application prospect.

Description

technical field [0001] The invention relates to the field of primary osteoporosis diagnosis and prognosis prediction in postmenopausal women, more specifically, the invention relates to a method for diagnosis and prognosis prediction of primary osteoporosis in postmenopausal women by means of detecting NUMB abnormalities. Background technique [0002] Osteoporosis (OP) is a systemic bone disease characterized by low bone mass, destruction of bone microarchitecture, increased bone fragility, and susceptibility to fracture (WHO). In 2001, the National Institutes of Health (NIH) of the United States proposed that osteoporosis is a disease of the skeletal system characterized by decreased bone strength and increased risk of fracture. Bone strength reflects two main aspects of bones, namely bone mineral density and bone quality. . [0003] The disease can occur in different genders and at any age, but it is more common in postmenopausal women and older men. Osteoporosis is divi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2800/108
Inventor 费琦杨雍林吉生
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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