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Ultrafast microflow mixer with viscosity adaptability

A mixer and adaptive technology, applied in the field of ultra-fast microfluidic mixers, can solve the problems of small sample consumption, etc., and achieve the effects of improving mixing efficiency, short mixing time, and simple manufacturing process

Active Publication Date: 2017-10-10
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: In order to solve the problem that the existing technology cannot combine fast mixing speed and small sample consumption under high viscosity conditions, the present invention provides a mixing channel formed by splicing circular arc channels to accelerate fluid mixing and improve the adaptability to fluid viscosity. revolutionary ultrafast microfluidic mixer

Method used

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  • Ultrafast microflow mixer with viscosity adaptability
  • Ultrafast microflow mixer with viscosity adaptability
  • Ultrafast microflow mixer with viscosity adaptability

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Effect test

Embodiment 1

[0019] Figure 2(a)-(b) shows figure 1 Partially enlarged schematic diagram of the mixing area in the middle, the mixing channel 2 of the present invention adopts an arc-shaped design; specifically, the mixing channel 2 can be an arc-shaped channel, as shown in Figure 2 (a), it can also be formed by multiple arcs The channels are connected, and the arc is preferably a semicircle; when the fluid passes through the curved mixing channel, a strong "secondary flow" will be generated in the cross section, and this "secondary flow" will be generated in the fluid in a laminar flow state Strong lateral movement, and this lateral movement will greatly increase the movement between the flow layers, thereby enhancing the mixing effect, so the mixing channel 2 adopts a circular arc design; in order to enhance the mixing effect, the mixing channel can also be composed of two The two arcs are preferably one larger and the other smaller, and the smaller arc is set on the side where the center...

Embodiment 2

[0021] The increase in the number of arcs can increase the mixing effect, but at the same time it will increase the complexity of the structure and the difficulty of processing and use; in addition, in order to make the fluid flow into the observation channel 3, the present invention further preferably adopts three arcs, Constitute the C-S type mixing channel as shown in Figure 2 (b); This C-S type mixing channel 2 is on the basis of adopting above-mentioned two circular arcs, introduces the 3rd circular arc, and concrete structure is as follows: by the first circular arc 201, The second circular arc 202 and the third circular arc 203 are connected in sequence; wherein, the first circular arc 201, namely the C-shaped channel, communicates with the end of the central channel 101, and its diameter is larger than that of the second circular arc 202 and the third circular arc The sum of the diameters of the arcs 203; the second arc 202 and the third arc 203 are spliced ​​into an S-...

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Abstract

The invention discloses an ultrafast microflow mixer with viscosity adaptability. The ultrafast microflow mixer is formed by sequential communication of an inlet passage, a mixing passage and an observation passage, wherein the inlet passage comprises a central passage body and two lateral passage bodies which are arranged on two sides of the central passage body and communicated with the same; the mixing passage is arc-shaped or is formed by connection of a plurality of arc-shaped passage bodies; the observation passage is integratedly shaped with the mixing passage or is jointed with the mixing passage in a communicated manner. The ultrafast microflow mixer is highly adaptive to flow viscosity, and is capable of obtaining a high mixing efficiency above 90% when flow viscosity is changed largely (by 1-30cp) and shortening the mixing time to microseconds; the ultrafast microflow mixer is simple in manufacturing technology, an integral mixer mould can be finished by a standard plane photoetching technology at one time, and complicated technologies including multiple exposures and alignment are not required.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to an ultrafast microfluidic mixer with viscosity adaptability. Background technique [0002] In recent years, Lab-on-a-chip (Lab-on-a-chip) has been widely researched and applied in the fields of biology, chemistry, medicine, etc. Microfluidic mixer is an important part of it. In the study of fast reaction kinetics , an ultrafast microfluidic mixer must be used. [0003] At present, most ultrafast microfluidic mixers work by increasing the Reynolds number of the mixing channel with a large flow rate to increase the mixing effect, but when the fluid is at a low Reynolds number, the mixing efficiency will be greatly reduced. However, the real environment of biological reactions is a cell environment with high viscosity. The increase of viscosity is accompanied by the decrease of the Reynolds number in the microfluidic mixer, which will lead to a significant decrease in the mixing efficiency of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F13/00
CPCB01F33/30
Inventor 朱利陈科祥陆辉崔一平
Owner SOUTHEAST UNIV