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Premixed feed additive for alleviating immunosuppression of weaned piglets and preparation method thereof

A premixed feed and immunosuppressive technology, which is applied in the field of livestock and poultry breeding, can solve the problems of weakening vaccine protection, declining immunity, and enhancing disease susceptibility, so as to improve the immune effect of vaccines, alleviate immunosuppression, and improve immunity. Effect

Inactive Publication Date: 2017-10-20
JINHUA AONONG BIOLOGICAL TECHNOLOGY CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the arrangement of a large number of vaccines at this stage, once immunosuppression occurs, the immunity of the body will be reduced, which will greatly weaken the protection of the vaccine and directly enhance the susceptibility of the animal body to diseases.

Method used

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  • Premixed feed additive for alleviating immunosuppression of weaned piglets and preparation method thereof
  • Premixed feed additive for alleviating immunosuppression of weaned piglets and preparation method thereof
  • Premixed feed additive for alleviating immunosuppression of weaned piglets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The test adopts a single factor test design, and the test selects about 240 weaned piglets with similar body weight, health, and similar genetic basis, weighing about 10 kg, three-way hybrid (Du Dachang), and randomly divides them into 5 treatments, and each treatment has 6 repetitions. Each replicate has 8 pigs, half male and half female. The five treatment groups are: positive control group, negative control group, negative control+0.05% additive group, negative control+0.15% additive group, negative control+0.25% additive group. In addition to the blank control group, other groups of test pigs were subcutaneously injected with cyclophosphamide (30 mg / kg) on ​​the 1d, 4d, 7d, 10d, 13d, 16d, and 19d of administration to create an immunosuppressive model. The test period is 20 days. The five treatment groups were fed with five experimental diets, and the diet formulas are shown in Table 1. The experimental basal diet was prepared according to the American NRC Pig Feed...

Embodiment 2

[0070] This embodiment alleviates the premixed feed additive of weaned piglet immunosuppression, and this premixed feed additive comprises the following components and content by weight: polysaccharide complex 240 parts, yeast extract 160 parts, vitamin E 140 parts, vitamin B 12 20 parts, 180 parts of soybean isoflavones and 25 parts of tea polyphenols.

[0071] The polysaccharide complex is prepared from raw materials including the following components and contents in parts by weight: 1 part of astragalus, 2 parts of Atractylodes macrocephala, 1 part of spray-dried yam powder, 0.5 part of sumac and 0.2 part of seaweed.

[0072] The preparation method of polysaccharide complex specifically comprises the following steps:

[0073] Step (1): Prepare materials according to the following components and parts by weight: 1 part of Astragalus membranaceus, 2 parts of Atractylodes macrocephala, 1 part of spray-dried yam powder, 0.5 part of sumac and 0.2 part of seaweed;

[0074] Step (2...

Embodiment 3

[0084] This embodiment alleviates the premixed feed additive of weaned piglet immunosuppression, and this premixed feed additive comprises the following components and the content of parts by weight: polysaccharide complex 400 parts, yeast extract 250 parts, vitamin E 220 parts, vitamin B 12 32 parts, 240 parts of soybean isoflavones and 50 parts of tea polyphenols.

[0085] The polysaccharide complex is prepared from raw materials including the following components and contents in parts by weight: 4 parts of astragalus, 4 parts of Atractylodes macrocephala, 3 parts of spray-dried yam powder, 2 parts of sumac and 1 part of seaweed.

[0086] The preparation method of polysaccharide complex specifically comprises the following steps:

[0087] Step (1): Prepare materials according to the following components and parts by weight: 4 parts of astragalus, 4 parts of Atractylodes macrocephala, 3 parts of spray-dried yam powder, 2 parts of sumac and 1 part of seaweed;

[0088] Step (2...

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Abstract

The invention relates to a premixed feed additive for alleviating immunosuppression of weaned piglets and a preparation method thereof. The premixed feed additive comprises the following components by weight: 240-400 parts of a polysaccharide compound, 160-250 parts of a yeast extract, 140-220 parts of vitamin E, 20-32 parts of vitamin B12, 180-240 parts of soybean isoflavone, and 25-50 parts of tea polyphenol. The polysaccharide compound is prepared from the following raw materials by weight: 1-4 parts of Astragalus, 2-4 parts of bighead atractylodes rhizome, 1-3 parts of Chinese yam spray-dried powder, 0.5-2 parts of Caesalpinia sappan, and 0.2-1 part of alga. During preparation, the polysaccharide compound, the yeast extract, vitamin E, vitamin B12, soybean isoflavone and tea polyphenol can be mixed evenly directly. Compared with the prior art, the additive provided by the invention has strongly effective effect in alleviating immunosuppression. At the same time, the premixed feed additive also has the effect of obviously improving the immunity of non-immunosuppressed piglets, and can effectively improve the immune effect of vaccines.

Description

technical field [0001] The invention belongs to the technical field of livestock and poultry breeding, and relates to a premixed feed additive for relieving immunosuppression of weaned piglets and a preparation method thereof. Background technique [0002] Immunosuppression refers to the destruction of organs, tissues and cells participating in the immune response under the action of single or multiple pathogenic factors, resulting in the interference of temporary or persistent antigen presentation, inhibition of antibody formation or Blocking and other immune response dysfunction is a manifestation of abnormal immune function, so that the immune function of the animal body is weakened or lost, and the susceptibility to disease is increased, making the animal in "sub-health". [0003] In recent years, in my country's pig production, due to the abuse of a large number of antibiotics, the pollution of mycotoxins in the feed, and the infringement of circovirus, etc., the immuno...

Claims

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Application Information

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IPC IPC(8): A23K50/30A23K50/60A23K20/163A23K10/16A23K20/153A23K20/174A23K20/121A23K20/10
CPCA23K10/16A23K20/10A23K20/121A23K20/153A23K20/163A23K20/174A23K50/30A23K50/60
Inventor 王新磊张敬学刘小成周通杨伟春李广杰隋晓东吴有林
Owner JINHUA AONONG BIOLOGICAL TECHNOLOGY CO LTD
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