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In-vivo enrichment device for circulating tumor cells

A tumor cell enrichment technology, applied in the field of medical devices, can solve the problems of low capture efficiency and low quality, and achieve the effects of improving the quality of life, preventing leakage, and excellent mechanical properties

Active Publication Date: 2017-10-20
HUADONG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an in vivo enrichment device for circulating tumor cells, thereby solving the problem of low efficiency and low quality of in vitro capture of circulating tumor cells in the prior art

Method used

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  • In-vivo enrichment device for circulating tumor cells
  • In-vivo enrichment device for circulating tumor cells
  • In-vivo enrichment device for circulating tumor cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as figure 1 Shown is an in vivo enrichment device 10 according to a preferred embodiment of the present invention. The device includes: a catheter body 1 that can reach the central vein through peripheral venous puncture, a plurality of sieve holes 2 are distributed on the tube wall of the catheter body 1, and the catheter body 1 is filled with capture particles 3 targeting CTC. The surface of the capture particle 3 is pre-assembled with a hydrophilic drug or a specific antibody 31 that specifically targets and binds to CTC6. The pore size of the screen hole 2 is smaller than that of the captured particles 3 to prevent the captured particles 3 from leaking out of the catheter body 1 . From figure 1 It can be seen from the figure that the catheter body 1 has a uniform diameter along its length.

[0041] The front end 4 of the catheter body 1 is a blind end to prevent leakage of captured particles.

[0042] The length of about 10 mm of the front end of the cathet...

Embodiment 2

[0048] Such as figure 2 Shown is an in vivo enrichment device 20 according to another preferred embodiment of the present invention. The structure of the device 20 is substantially similar to that of the device 10 of the previous embodiment, the only difference is that the catheter body 1 has an uneven diameter along its length. According to this particularly preferred embodiment, the catheter body 1 has along its length a plurality of spherical protrusions 12 spaced apart from each other by a cylindrical portion 11, the diameter of which is always greater than that of the cylindrical portion 11. diameter. This structure is also called "spherical expansion type". The advantage of this "spherical expansion type" is that it can increase the volume of blood in contact with the captured particles 3. If the clinical stage is earlier and the vessel diameter is appropriate, this "spherical expansion type" is theoretically preferred for efficient and high-efficiency. Texture colle...

Embodiment 3

[0051] According to this embodiment, the present invention also provides an optional operating procedure for the above-mentioned in vivo enrichment device 10, specifically as follows:

[0052] 1) The device should be used by medically professionally trained personnel, always observing routine hygienic requirements.

[0053] 2) Position the patient so that the patient's limb is at 90 degrees to the body.

[0054] 3) Place a waterproof pad or a disposable pad under the punctured limb, and place a tourniquet.

[0055] 4) Select the puncture site. The principle of vein selection is as follows: the basilic vein is the first choice, followed by the median vein, and then the cephalic vein.

[0056] 5) From the pre-puncture point along the vein to the right sternoclavicular joint, subtract 2-5cm from the measured value to get the catheter insertion length.

[0057] 6) Wear a sterile isolation gown (assisted by an assistant) and sterile gloves.

[0058] 7) Lay out the sterile table:...

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Abstract

The invention provides an in-vivo enrichment device for circulating tumor cells. The in-vivo enrichment device comprises a catheter body capable of puncturing to a central vein through a peripheral vein, a plurality of sieve holes are formed in the catheter wall of the catheter body, the catheter body is filled with trapped particles of targeting circulating tumor cells, and a blind end is arranged at the front end of the catheter body. According to the in-vivo enrichment device for the circulating tumor cells, the inside of the catheter body is filled with assembling hydrophilic medicine or trapped particles of a specific antibody, the sieve holes are formed in the pipe wall of the catheter body, CTC in blood is continuously combined on the trapped particles inside the catheter body through specific targeting accordingly, and efficient and high-quality trapping of the CTC in blood is achieved; the in-vivo enrichment device has the advantages that the enrichment device is used in vivo, efficient trapping is achieved, and clinical application is convenient; the in-vivo enrichment device can provide molecular-gene diagnosis information based on the CTC for early diagnosis, targeting therapy, recurrence and metastasis detection, treatment evaluation and the like of tumor, and has quite-broad application prospects.

Description

technical field [0001] The invention relates to the field of medical devices, and more particularly to an in vivo enrichment device for circulating tumor cells. Background technique [0002] With the continuous improvement of the requirements for precise diagnosis and treatment of malignant tumors, liquid biopsy technology represented by circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) has become a research hotspot at home and abroad in recent years. CTC refers to the tumor cells derived from the primary tumor or metastases, which break away from the basement membrane and enter blood vessels. CTCs can exist alone in the blood circulation, or they can accumulate into clusters, adhere to other blood cell clusters, and form circulating tumor microemboli (CTM), which have stronger proliferation and metastasis potential, and are the main reason for postoperative recurrence in patients with malignant tumors. and an important cause of distant metastasis. A number o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/02C12N5/09
CPCA61B10/02C12N5/0693
Inventor 郑向鹏焦玉新任艳萍保志军
Owner HUADONG HOSPITAL
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