Method for improving dissolution of effective ingredients of silybum marianum shells

An active ingredient, the technology of milk thistle, which is applied in the field of improving the dissolution of active ingredients of milk thistle shell, can solve the problems of unfavorable effective ingredient dissolution, high hardness of milk thistle shell, etc., and achieve improved yield, reduced solvent consumption, and shorter production cycle. shortened effect

Active Publication Date: 2017-10-20
ZHONGXING PHARM CO LTD JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing silymarin extraction method, the milk thistle shell has high hardness, smooth surface, wax protection, and unfavorable dissolution of active ingredients. The present invention proposes a method for improving the dissolution of effective ingredients from milk thistle shell

Method used

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  • Method for improving dissolution of effective ingredients of silybum marianum shells
  • Method for improving dissolution of effective ingredients of silybum marianum shells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 15 kg of milk thistle seed shells, add 0.75 kg of water, stir for 5 minutes with a CH-200 tank mixer, turn off the mixer and moisten for 5 minutes, and separate through spiral rolling (380V, 5.5KW, screw shaft length 440mm, pressure 1.5T ), 15.6kg of milk thistle seed helical husks after separation, the husks were dried by high-frequency microwave (5.2GHZ), and dried for 2 minutes at a low temperature of 30° C. 14.7kg shell bar, denoted as shell bar 1.

[0025] In addition, a group of parallel experiments were conducted with the same experimental conditions as above, except that the shell strips were not subjected to high-frequency microwave drying treatment, but were directly vacuum-dried until the water content was below 3%, to obtain shell strips 1-1.

Embodiment 2

[0027] Take 15kg of milk thistle seed shells, add 1.30kg of water, stir for 8 minutes through CH-200 tank mixer, turn off the mixer and moisten for 7 minutes, and separate through spiral rolling (380V, 5.5KW, screw shaft length 440mm, pressure 1.5T ), 15.7kg of the separated milk thistle seed spiral shell bar, the separated milk thistle seed spiral shell bar was dried by high-frequency microwave (5.2GHZ), and dried at a low temperature of 40°C for 3 minutes to obtain a water content of 14.8 kg of milk thistle seed spiral husk strips with less than 3%, recorded as husk strips 2.

[0028] In addition, a group of parallel experiments were conducted with the same experimental conditions as above, except that the shell strips were not subjected to high-frequency microwave drying treatment, but were directly vacuum-dried until the moisture content was below 3%, to obtain shell strips 2-1.

Embodiment 3

[0030] Take 15kg of milk thistle seed shells, add 1.50kg of water, stir for 10 minutes with a CH-200 tank mixer, turn off the mixer and moisten for 10 minutes, and separate by spiral rolling (380V, 5.5KW, screw shaft length 420mm, pressure 2T) 15.6kg of milk thistle seed helical husk bar after separation, the milk thistle seed helical husk bar after separation is through high-frequency microwave drying (5.2GHZ), dry 3 minutes under the low temperature 45 ℃, obtain moisture content in 3 15kg of milk thistle seed spiral-shaped husk strips below %, denoted as husk strip 3.

[0031] In addition, a group of parallel experiments were conducted with the same experimental conditions as above, except that the shell strips were not subjected to high-frequency microwave drying treatment, but were directly vacuum-dried until the water content was below 3%, and the shell strips 3-1 were obtained.

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Abstract

The invention provides a method for improving dissolution of effective ingredients of silybum marianum shells. The method comprises the following steps: adding water in silybum marianum seed shells and stirring, and then stopping stirring and moistening to enable the silybum marianum shells to fully absorb water and then to be in a softened state; enabling the moistened silybum marianum shells to pass through a spiral rolling and separating device to enable the water content in the shells to be controlled to be 5% or below so that scattered silybum marianum seed shells are changed into spiral shell strips; feeding the shell strips into a closed high-frequency microwave drying device through a conveying belt and drying for 2-3 minutes, controlling water to be 3% or below, and keeping the shell strips spiral to obtain the treated silybum marianum shell strips; and (4) carrying out solvent extraction on the treated silybum marianum shells according to the conventional method. The general flavone is extracted by the silybum marianum seed shells, the feeding amount of the treated silybum marianum seed shells treated by the same extracting equipment is two times greater than the original feeding amount, the energy consumption is halved, the relative production period is also halved, and the yield of the general flavone of the silybum marianum relative to shells is improved by about 2%.

Description

technical field [0001] The invention relates to a technology for extracting active ingredients of medicines, in particular to a method for improving the dissolution of active ingredients in milk thistle shells. Background technique [0002] Milk thistle (Silybum marianum) is an herb of Compositae, and its seeds are mainly used to extract and separate its active ingredient silymarin. The traditional process is to extract silymarin from the milk thistle cake after pressing milk thistle seeds. Since silymarin exists completely in the seed shell, the traditional process will not only interfere with the purity of the extracted active ingredients from the milk thistle seeds, but also consume solvents. Big. Theoretically, extracting silymarin from silymarin seed husk not only has high purity of active ingredients, but also relatively large amount of material, and low solvent consumption. The technical bottleneck of milk thistle shell feeding is the low feeding amount of each mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28
CPCA61K36/28A61K2236/10A61K2236/17A61K2236/33
Inventor 武俊明黄文娟魏云
Owner ZHONGXING PHARM CO LTD JIANGSU
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