Rhizoma alismatis soup extract and application thereof

A technology of extracts and Alisma decoction, which is applied in the direction of drug combination, medical preparations containing active ingredients, separation/purification of carbonyl compounds, etc., can solve the problems that the research of chemical components has not been reported yet

Active Publication Date: 2017-10-20
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the chemical components in the single-flavored decoction pieces of Alisma and Atractylodes Rhizoma Atractylodes Rhizome and the alcohol extract has been quite in-depth, but the research on the relevant chemical components of the whole prescription of Alisma decoction has not been reported

Method used

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  • Rhizoma alismatis soup extract and application thereof
  • Rhizoma alismatis soup extract and application thereof
  • Rhizoma alismatis soup extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Take 4500g of the mixture of Alisma and Atractylodes macrocephala (mass ratio 1:0.4), decoct 3 times with 8 times the amount of water for 2.5h, 2.5h, and 2h respectively, and filter the combined decoction with 3 layers of gauze, and decompress Concentrate to a density of 1.1-1.2g·mL -1 , filtered under reduced pressure, and the filtrate was taken to obtain the total extract.

[0052] Extract the total extract with n-butanol to obtain n-butanol extract and n-butanol aqueous phase; take n-butanol aqueous phase and continue to extract with ethyl acetate to obtain ethyl acetate extract and ethyl acetate aqueous phase; The ethyl acetate aqueous phase was extracted with petroleum ether to obtain a petroleum ether extract and a petroleum ether aqueous phase. The extracts were all concentrated under reduced pressure into extracts to obtain 52.18 g of the n-butanol layer extract and 13.77 g of the ethyl acetate layer extract. g, petroleum ether layer extract 2.72g.

[0053] Af...

Embodiment 2

[0076] Example 2 Alisma decoction extract prevents and treats hyperlipidemia

[0077] 1. Animal model: Select 120 SPF grade mice, both male and female, with a body weight of 20±2g, and adopt a high-fat feed feeding method to establish an experimental mouse model of hyperlipidemia. Pre-feed in the laboratory for 1 week before the experiment. During the experiment, 10 mice were randomly selected as the normal control group (N) and fed with ordinary feed. All other mice were fed with high-fat feed for 4 weeks to establish an experimental mouse high-fat diet. For the hyperemia model, after feeding for 4 weeks, blood was taken from the tail to measure the fasting TC level of the modeled mice, and the mouse TC value greater than 7 mmol / L was considered as a successful model. High-fat feed quality composition: basic feed 78.8%, egg yolk powder 10%, lard 10%, cholesterol 0.2%. The basic feed was purchased from the market.

[0078] 2. Grouping: Divide the hyperlipidemic mice with suc...

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Abstract

The invention discloses rhizoma alismatis soup extract and an application thereof. Based on the prior art, proper separating and purifying conditions are screened and determined to finally obtain three novel compounds similar in chemical structure. The three novel compounds have blood fat reducing effects to different extents. The rhizoma alismatis soup extract is one of the following substances as shown in the specification.

Description

(1) Technical field [0001] The invention relates to a new compound with medicinal activity isolated from Alisma decoction and its application, which belongs to the field of medicine. (2) Background technology [0002] Alisma Decoction was first seen in the chapter "Synopsis of the Golden Chamber: Syndrome and Treatment of Phlegm, Retention, Cough, and Syndrome No. 12". It is mainly used to cure "bitterness and dizziness" caused by "drinking under the heart". The lower part of the heart is in the stomach, if the drink is stopped in the stomach, the spleen will not function well, causing the clear yang not to rise, the turbid yin not to fall, and the upper part to cause dizziness. During the treatment, the method of eliminating drinking and diuresis, invigorating the spleen and making water must be given. This prescription focuses on Alisma diarrhea, which is sweet and cold in nature, and focuses on promoting water and exuding dampness, so that the stopped drinking will go a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08C07C49/513C07C45/78C07C45/79C07C45/80A61K31/357A61K31/352A61K31/122A61P3/06A61P9/12
Inventor 骆倩刘志东祁东利林徐剑施晓萍张兵
Owner CHIATAI QINGCHUNBAO PHARMA
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