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External medicine composite for treating psoriasis

A technology of external medicine and composition, which is applied in the direction of drug combination, skin diseases, active ingredients of amides, etc., and can solve the problems that there is no compound preparation to treat psoriasis, etc.

Inactive Publication Date: 2017-10-27
XIAMEN ENCHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] After searching, so far, there is no report of treating psoriasis with this compound preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Ointment (unit: g):

[0024] Tazarotene 0.05 urea 10 cetyl alcohol 0.5 White Vaseline 9.5 lanolin 2.0 stearic acid 12 Propylene Glycol 10 ethanol 10 glycerin 2 Triethanolamine 1.0 Nepal methyl ester 0.2 Propyl Nepal 0.05 purified water add up to 100

[0025] The preparation method is as follows:

[0026] Dissolve urea in water heated to 80-85°C for later use; then stir separately and add propylene glycol, glycerin, triethanolamine, methyl Nepalese ester, and propyl Nepalese ester to purified water (water phase); see white petrolatum, cetyl alcohol, wool Stir the butter and stearic acid evenly and heat to 80-85°C (oil phase); add the water phase to the oil phase and add tazarotene dissolved in ethanol with constant stirring, and slowly cool to room temperature.

Embodiment 2

[0028] Ointment (unit: g)

[0029] Tazarotene 0.1 urea 15 stearyl alcohol 7 White Vaseline 15 liquid paraffin 5 Glyceryl monostearate 3 stearic acid 2 Propylene Glycol 10 ethanol 15 glycerin 5 Triethanolamine 1.0 Nepal methyl ester 0.2 Propyl Nepal 0.05 purified water add up to 100

[0030] The preparation method is as follows:

[0031] Dissolve tazarotene and urea in ethanol and propylene glycol solutions for later use; then stir and add triethanolamine, glycerin, methyl and propyl Nepal to purified water respectively, and heat to 80-85°C (water phase); cetyl hard Fatty alcohol, white petrolatum, liquid paraffin, glyceryl monostearate, and stearic acid are heated to 80-85°C (oil phase); add the water phase to the oil phase to form a cream, then add the drug solution to continue emulsification, and keep stirring , slowly cooled to room temperature.

Embodiment 3

[0033] Cream (unit: g):

[0034] Tazarotene 0.05 urea 10 Polyethylene glycol-7-stearate 10 cetostearyl alcohol 3 liquid paraffin 8 Butylated Hydroxytoluene (BHT) 0.1 Nepal methyl ester 0.2 Propyl Nepal 0.05 Propylene Glycol 10 ethanol 10 Triethanolamine 1.0 purified water add up to 100

[0035] The preparation method is as follows:

[0036] Dissolve tazarotene and urea in ethanol and propylene glycol solution, then add butylated hydroxytoluene (BHT), triethanolamine, methyl Nepal, propyl Nepal, and purified water, stir evenly and heat to 80-85°C (water phase ); heat cetostearyl alcohol, liquid paraffin, polyethylene glycol-7-stearate to 80-85°C (oil phase); add the water phase to the oil phase to form a cream, and keep stirring, slowly Cool to room temperature.

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PUM

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Abstract

The invention provides an external medicine composite for treating psoriasis. Preparation forms of the external medicine composite include cream, ointment and gel. The medicine composite comprises 0.05-0.1%(w / w) of tazarotene, 10-20%(w / w) of urea and a pharmaceutically acceptable excipient. The medicine composite has a significant curative effect on the psoriasis, and is good in safety.

Description

technical field [0001] The invention relates to an external pharmaceutical composition for treating psoriasis. More specifically, the present invention relates to a pharmaceutical composition for external use containing tazarotene and urea. Background technique [0002] Psoriasis, commonly known as psoriasis, is a common chronic relapse-prone inflammatory skin disease with characteristic skin lesions. Induced in sensitive individuals. Pathological changes include excessive hyperplasia and incomplete differentiation of skin keratinocytes, infiltration of inflammatory cells, and dilation of dermal blood vessels. The clinical manifestations are mainly erythema and scales; the skin lesions are red papules and macules of different sizes, with multiple layers of dry white silver scales on them, and patients often feel itchy. It can occur in any part of the human body, but it is more common on the scalp and extremities, and it is usually aggravated in winter. Harm: In addition ...

Claims

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Application Information

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IPC IPC(8): A61K31/4436A61K31/17A61P17/06A61P17/10A61P17/12A61P17/00
Inventor 郭云珍欧阳旭卢建勋王斌
Owner XIAMEN ENCHENG PHARMA CO LTD
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