A kind of high-performance rosmarinic acid molecular surface imprinted particles and preparation method thereof

A technology of rosmarinic acid and surface imprinting, applied in chemical instruments and methods, other chemical processes, alkali metal compounds, etc., can solve the problem of difficult separation of components with similar structures, low separation efficiency and recovery rate, and low purity of extracted drugs and other problems, to achieve the effect of specific recognition selectivity, simple operation and low cost

Active Publication Date: 2019-06-07
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional separation materials have poor selectivity and are not easy to separate components with similar structures, resulting in low purity of the extracted drugs and difficulty in ensuring drug efficacy. This requires multiple or multi-stage separations to obtain active components with high purity, but These traditional separation materials have low separation efficiency and recovery rate, and will cause environmental pollution

Method used

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  • A kind of high-performance rosmarinic acid molecular surface imprinted particles and preparation method thereof
  • A kind of high-performance rosmarinic acid molecular surface imprinted particles and preparation method thereof
  • A kind of high-performance rosmarinic acid molecular surface imprinted particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1: Preparation of Grafted Microparticles

[0029] Pour 3g of AMPS-modified silica gel particles, 30mL of monomeric DMAEMA and 120mL of distilled water into a four-necked flask, exhaust the air inside the four-necked flask with nitrogen, then add 0.3g of ammonium persulfate (initiator), at 50°C Reacting at high temperature for 6 hours, the monomer DMAEMA is attached to the surface of silica gel particles, thereby preparing grafted particles.

[0030] In this step, the modification process of the silica gel particles modified by AMPS is as follows:

[0031] Weigh 10g of silica gel particles into a four-neck flask, add 100mL of distilled water, then add 10mL of AMPS, react at 50°C for 24 hours, after the reaction, suction filter (wash to neutral) to obtain modified particles.

[0032] The reason why we choose the silica gel particles modified by AMPS is that after the silica gel particles are modified by AMPS, a large amount of amino groups can be introduced into the...

Embodiment 2

[0041] Step 1: Preparation of Grafted Microparticles

[0042] 2.25g of silica gel particles modified by AMPS, 25mL of monomer DMA EMA and 125mL of distilled water were poured into a four-necked flask, and the air in the four-necked flask was purged with nitrogen, then 2.5g of ammonium persulfate (initiator) was added, and the React at 35° C. for 6 hours, so that the monomer DMAEMA is attached to the surface of the silica gel particles, thereby preparing grafted particles.

[0043] In this example, the silica gel particles modified by AMPS are the same as those in Example 1.

[0044] Step 2: Preparation of positively charged functional particles

[0045] Dissolve 1.2 g of 2-chloroethylamine hydrochloride (a quaternizing agent) in 150 mL of water, adjust the pH to 7.0, then add 1.5 g of grafted microparticles, and react at a temperature of 60 ° C for 14 h to make the tertiary The amine group undergoes a quaternization reaction with the chloroalkyl group of the quaternizing age...

Embodiment 3

[0052] Step 1: Preparation of Grafted Microparticles

[0053] 2.25g of silica gel particles modified by AMPS, 25mL of monomer DMA EMA and 125mL of distilled water were poured into a four-necked flask, and the air inside the four-necked flask was purged with nitrogen, then 0.25g of ammonium persulfate (initiator) was added, and React at 35° C. for 6 hours, so that the monomer DMAEMA is attached to the surface of the silica gel particles, thereby preparing grafted particles.

[0054] In this example, the silica gel particles modified by AMPS are the same as those in Example 1.

[0055] Step 2: Preparation of positively charged functional particles

[0056] Dissolve 1.2g of 2-chloroethylamine hydrochloride (a quaternizing agent) in 150mL of water, adjust the pH to 7.0, then add 1.5g of grafted particles, and react at 60°C for 14 hours to make the tertiary amino group of the grafted particles The group undergoes a quaternization reaction with the chloroalkyl group of the quatern...

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Abstract

The invention discloses a high-performance rosmarinic acid molecule surface imprinted particle and a preparation method thereof. The preparation method comprises the following steps: 1. adding an initiator into a water solution system, inoculating monomer DMAEMA onto the surface of AMPS-modified silica gel particles, and preparing to obtain grafted particles; 2. by taking 2-chloroethylamine hydrochloride as a quaternization reagent, leading the tertiary amine group of the grafted particle to have quaternization reaction with the chloroalkyl group of the quaternization reagent, and preparing to obtain functional particle with positive charge; 3. leading functional particle to perform saturation adsorption to rosmarinic acid molecules, and then reacting with a cross-linking agent, to complete molecule surface imprinting process; and 4. filtering and separating the product particle. The high-performance rosmarinic acid molecule surface imprinted particle and the preparation method thereof have the benefits that (1) the preparation technology is simple, the operation is simple and convenient, and the cost is low; and (2) the prepared imprinted particle has specific recognition selectivity and high adsorption capacity, thus being a high-performance imprinted particle, and being capable of separating and purifying rosmarinic acid from natural plants.

Description

technical field [0001] The invention relates to a microparticle and a preparation method thereof, in particular to a high-performance rosmarinic acid molecular surface imprinted microparticle and a preparation method thereof, belonging to the technical field of natural medicine separation and functional polymers. Background technique [0002] With the continuous improvement of people's living standards, the development of active ingredients in natural medicines and plants is becoming more and more popular. However, natural plants not only have a relatively low content of active ingredients and are not easy to enrich, but also contain a wide variety of compounds in the system, the system is complex, macromolecules and small molecules, living and non-living substances coexist, especially the existence of molecules with similar structures, leading to separation Purification is difficult. In addition, the active ingredients of many natural products are sensitive to heat and eas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/34C08F2/44C08J9/26B01J20/26B01J20/30B01J20/28
CPCB01J20/268B01J20/28002B01J20/28021C08F2/44C08F120/34C08J9/26C08J2201/0422C08J2333/14
Inventor 史楠李晓君陈涛张志军孙博翰高保娇高莉李继文
Owner ZHONGBEI UNIV
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