Microfluidic chip for detecting tumor markers based on uniformly distributed microspheres, and use method thereof
A microfluidic chip, tumor marker technology, applied in the field of biosensors, can solve problems such as obstruction of liquid flow, complicated experimental steps, unfavorable analysis, etc., to prevent clogging, simplify experimental operations, and avoid the effects of fluorescent signal interference.
Active Publication Date: 2017-11-07
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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The invention relates to a microfluidic chip for detecting tumor markers based on uniformly distributed microspheres, and a use method thereof. The microfluidic chip comprises a sample inlet, a sample outlet and a plurality of micro-column arrays parallel to a liquid flowing direction, wherein the gaps between the micro-column arrays are main flowing channels, and the narrowest gap between the adjacent micro-columns in the micro-column arrays is slightly smaller than the diameter of the microsphere. According to the present invention, based on the principle of fluid diffusion, the structure is simple, the complex flow resistance theoretical calculation is not required, the microspheres can be uniformly arranged between the gaps of the micro-columns, and the interference of the fluorescence signals can be avoided with the discretely distributed microspheres; the microspheres can be combined with different antibodies according to the requirements so as to detect different markers; and the sample injection time can be shortened through the used incubation method, the sample injection and the washing are integrated so as to simplify the experiment operation, and the microfluidic chip can be used for the biochemical detection using the microspheres as the carrier, and has the good application prospects.
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