An addition type silicone pressure-sensitive adhesive used for medicines and a preparing method thereof

A silicone pressure-sensitive adhesive and additive technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, adhesives, etc., can solve the problems of low adhesion between the colloid and the skin, allergies, and lack of practicability, and achieve Excellent rheological properties, moderate cohesion, and easy coating and construction

Active Publication Date: 2017-11-10
南宁市六分仪生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic solvents need to be used in the production process of such products, and the residual solvents may cause adverse consequences such as allergies during use. At the same time, the adhesive ability of the colloid and the skin is very small, and it does not have medical practicability.
It can be seen that the currently published patents for silicone pressure-sensitive adhesives are not enough to fully satisfy the pharmaceutical industry's requirements for silicone pressure-sensitive adhesives, which are safe, non-toxic, easy to coat, well bonded to common substrates, fast vulcanization, and reliable in adhesion. adjustment, can adapt to many requirements such as rapid production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example is an addition type silicone pressure-sensitive adhesive for medicine, which contains the following raw materials in parts by weight: 100 parts of vinyl silicone oil, 8 parts of hydrogen-containing silicone oil, 3 parts of filler, 0.1 part of inhibitor and 0.15 part of catalyst.

[0029] The vinyl silicone oil is prepared by uniformly mixing 35 parts of terminal vinyl silicone oil with a viscosity of 5000mPa.s, 45 parts of terminal vinyl silicone oil with a viscosity of 10000mPa.s, and 20 parts of terminal vinyl silicone oil with a viscosity of 20000mPa.s. into, a total of 100 parts by weight. The hydrogen-containing silicone oil is a terminal-group hydrogen-containing silicone oil, containing at least two Si—H bonds, a viscosity of 250 mPa.s, and a hydrogen content of 0.35%. The filler is fumed silica (silica) with a specific surface area of ​​200m 2 / g, the particle size is less than 20nm. The catalyst is chloroplatinic acid-divinyltetramethyldisiloxane...

Embodiment 2

[0034] This embodiment is an addition type silicone pressure-sensitive adhesive for medicine, which contains the following raw materials in parts by weight: 100 parts of vinyl silicone oil, 5 parts of hydrogen-containing silicone oil, 5 parts of filler, 0.15 part of inhibitor and 0.15 part of catalyst.

[0035] The vinyl silicone oil is prepared by uniformly mixing 30 parts of terminal vinyl silicone oil with a viscosity of 5000mPa.s, 50 parts of terminal vinyl silicone oil with a viscosity of 15000mPa.s, and 20 parts of terminal vinyl silicone oil with a viscosity of 20000mPa.s. into, a total of 100 parts by weight. The hydrogen-containing silicone oil is a terminal-group hydrogen-containing silicone oil containing at least three Si—H bonds, a viscosity of 300 mPa.s, and a hydrogen content of 0.55%. The filler is fumed silica (silica) with a specific surface area of ​​200m 2 / g, the particle size is less than 20nm. The catalyst is chloroplatinic acid-divinyltetramethyldisil...

Embodiment 3

[0040] This example is an addition type silicone pressure-sensitive adhesive for medicine, which contains the following raw materials in parts by weight: 100 parts of vinyl silicone oil, 5 parts of hydrogen-containing silicone oil, 4 parts of filler, 0.15 part of inhibitor and 0.2 part of catalyst.

[0041] The vinyl silicone oil is uniformly mixed with 55 parts of terminal vinyl silicone oil with a viscosity of 20000 mPa.s and 45 parts of terminal vinyl silicone oil with a viscosity of 30000 mPa.s, with a total weight fraction of 100 parts. The hydrogen-containing silicone oil is a terminal-group hydrogen-containing silicone oil containing at least three Si—H bonds, a viscosity of 300 mPa.s, and a hydrogen content of 0.55%. The filler is fumed silicon dioxide (white carbon black), its specific surface area is 200m2 / g, and its particle size is less than 20nm. The catalyst is chloroplatinic acid-divinyltetramethyldisiloxane complex; the inhibitor is 2-methyl-3-butynyl-2-alcohol...

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Abstract

An addition type silicone pressure-sensitive adhesive used for medicines and a preparing method thereof are disclosed. Raw materials of the addition type silicone pressure-sensitive adhesive include, by weight, 100 parts of vinyl silicone oil, 5-10 parts of hydrogen-containing silicone oil, 3-5 parts of a filler, 0.03-0.3 part of an inhibitor and 0.03-0.3 part of a catalyst. The pressure-sensitive adhesive is nontoxic, nonirritant, waterproof and breathable, has good initial adhesive force, holding power and peel strength, can be uncovered and adhered repeatedly, and is a pressure-sensitive adhesive material having ideal properties for medicines.

Description

technical field [0001] The invention relates to the field of silicone pressure-sensitive adhesives, in particular to an addition-type silicone pressure-sensitive adhesive and a production method thereof. Background technique [0002] Transdermal drug delivery has many advantages, such as drug absorption is not affected by digestive tract factors, avoids liver first-pass effect, can be administered flexibly, and is easy to slow and control release. Therefore, transdermal preparations will have extremely broad development prospects. In medical practice, in order to fix the transdermal drug delivery system on the drug delivery site, people often use pressure-sensitive adhesive tape or plaster to apply it directly to the affected area. Traditional pressure-sensitive adhesives mostly use polyacrylate or polyurethane as the main raw material. Although they are cheap and widely used, they have skin toxicity and strong irritation (acrylic compound monomers are toxic and polyurethan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J183/07C09J183/05C09J11/04C09J11/06C09J7/04A61K9/70A61K47/34
CPCA61K47/34A61K9/7023C09J11/04C09J11/06C09J183/04C08K2201/011C08L2205/025C09J2483/00C09J2400/263C09J2301/122C09J2301/302C09J2301/408C08L83/04C08K3/36
Inventor 段伟昌何百寅蒋福东
Owner 南宁市六分仪生物科技有限责任公司
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