Surgical suture doped with bioactive substances and preparation method of surgical suture

A biologically active substance and surgical suture technology, applied in the field of surgical medicine, can solve the problems of being unsuitable for deep trauma wound suturing and short degradation time, and achieve good blood compatibility and tissue compatibility, long biodegradation time, and good Biosecurity Effects

Inactive Publication Date: 2017-11-24
北京惠嘉企业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its short degradation time make...

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  • Surgical suture doped with bioactive substances and preparation method of surgical suture
  • Surgical suture doped with bioactive substances and preparation method of surgical suture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A surgical suture infused with biologically active substances, made of the following parts by weight of raw materials: 100 parts by weight of silk sericin, 25 parts of dextran, 6 parts of pantographia extract, 5 parts of peruviana extract, 6 parts of thistle extract, 6 parts of Shilong beard extract, 8 parts of Angelica sinensis extract, 3 parts of glycerin, and 2 parts of bisabolol.

[0018] The extraction method of the extract of Pantoea paniculata is: sun-dried paniculata paniculata, ground into powder, refluxed extraction with 4 times the weight of water for 3 times, combined the filtrate, and evaporated to dryness. The extraction method of the peruviana extract is as follows: sun-dry the peruviana, grind it into a powder, add 4 times the weight of water for reflux extraction 3 times, combine the filtrate, and evaporate to dryness. The extraction method of thistle extract is as follows: dry thistle, grind it into powder, add 4 times the weight of 70% ethanol aqueous so...

Embodiment 2

[0023] A surgical suture infused with biologically active substances, which is made of the following parts by weight of raw materials: 80 parts by weight of silk sericin, 20 parts of dextran, 3 parts of pantographia extract, 4 parts of peruviana extract, 3 parts of thistle extract, 3 parts of Shilongbeard extract, 5 parts of Angelica sinensis extract, 2 parts of glycerin, 1 part of bisabolol.

[0024] The method for extracting the extract of Pantoea paniculata is as follows: drying Pantoea paniculata into a powder, adding 3 times the weight of water for reflux extraction for 3 times, combining the filtrate, and evaporating to dryness. The extraction method of the peruviana extract is as follows: sun-dry the peruviana, grind it into powder, add 3 times the weight of water to reflux for 3 times, combine the filtrate, and evaporate to dryness. The extraction method of thistle extract is as follows: dry thistle, ground into powder, add 3 times the weight of 70% ethanol aqueous soluti...

Embodiment 3

[0029] A surgical suture infused with biologically active substances, made of the following parts by weight of raw materials: 120 parts by weight of silk sericin, 30 parts of dextran, 8 parts of pantographia extract, 6 parts of peruviana extract, 8 parts of thistle extract, 8 parts of Shilongbeard extract, 10 parts of Angelica sinensis extract, 5 parts of glycerin, 3 parts of bisabolol.

[0030] The extraction method of the extract of Panax paniculata is as follows: dry Paniculata paniculata, grind it into a powder, add 5 times the weight of water for reflux extraction 3 times, combine the filtrate, and evaporate to dryness. The extraction method of the peruviana extract is as follows: sun-dry the peruviana, grind it into a powder, add 5 times the weight of water for reflux extraction 3 times, combine the filtrate, and evaporate to dryness. The extraction method of thistle extract is as follows: dry thistle, grind it into powder, add 5 times the weight of 70% ethanol aqueous solu...

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Abstract

The invention discloses a surgical suture doped with bioactive substances and a preparation method of the surgical suture, belonging to the technical field of surgical medicines. The surgical suture is prepared from the following raw materials in parts by weight: 80-120 parts of silk sericin, 20-30 parts of glucan, 3-8 parts of a canscora lucidissima extract, 4-6 parts of a peruvian groundcherry herb extract, 3-8 parts of a Japanese thistle herb extract, 3-8 parts of a scincidae extract, 5-10 parts of angelica pubescens extract, 2-5 parts of glycerin and 1-3 parts of bisabolol. The prepared surgical suture has good biosecurity, has no toxic or side effects and irritation and has the functions of rapidly stopping bleeding, resisting bacteria, diminishing inflammation, invigorating blood circulation, dispersing blood stasis, relievin internal heat or fever, promoting granulation and wound healing, preventing adhesion and the like; and furthermore, the prepared surgical suture has good blood compatibility and tissue compatibility, has no inflammatory response and human body exclusion, can be completely degraded and absorbed after a wound is healed, is relatively long in biodegradation time and suitable for suturing deep wounds.

Description

Technical field [0001] The invention belongs to the technical field of surgical medicine, and specifically relates to a surgical suture mixed with biologically active substances and a preparation method thereof. Background technique [0002] At present, absorbable sutures are commonly used in surgical sutures. Absorbable sutures mainly include catgut and synthetic fiber. Catgut is made from the submucosa of the small intestine of sheep. There are two types: ordinary and chrome. The absorption time of ordinary gut is shorter (4 to 5 days), and it is mostly used for ligation and skin suture. The chromium gut has a long absorption time (14-21) days and is used to suture deep tissues. Gut is a foreign protein, and the tissue reacts more severely during the absorption process. Therefore, when too much or too thick catgut is used, the wound inflammatory reaction is obvious. Its advantage is that it can be absorbed without foreign matter. In 2010, catgut was mainly used for suture...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/06A61L17/00
CPCA61L17/005A61L17/06A61L17/10A61L2300/30A61L2300/404A61L2300/408C08L5/02
Inventor 周美霞
Owner 北京惠嘉企业管理有限公司
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