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Biodegradable medical hemostasis paper and preparation method thereof

A technology of biological and polymer substances, applied in the field of biodegradable medical hemostatic paper and its preparation, can solve problems such as toxicity, non-conformity with the concept of green environmental protection, and potential safety hazards

Pending Publication Date: 2017-11-24
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cross-linking agent uses aldehyde cross-linking agents such as glutaraldehyde, which is toxic to the human body and has potential safety hazards, which does not conform to the concept of green environmental protection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Use a balance to weigh 1.9g of sodium alginate and add it to 150g of deionized water, stir it with a magnetic force at 30°C to dissolve completely, add 1.76g of sodium periodate solid, and react in the dark for 48 hours, the temperature is not higher than 30°C, add 0.41g of ethylene glycol was used to terminate the reaction, 150g of ethanol and 3.0g of sodium chloride were added, the layers were statically separated, filtered with suction, and dried in a vacuum oven at 40°C for 48h. Oxidized sodium alginate was obtained.

[0021] (2) Add 1.5 g of sodium alginate, 1.5 g of hydroxymethyl cellulose, and 3.0 g of gelatin into 85.5 g of deionized water with a balance, and stir magnetically at 40°C until completely dissolved.

[0022] (3) Weigh 1.70g of 1,2-propanediol and 5.30g of glycerol, add the system obtained in step (2), and stir to dissolve completely. Weigh 1.5 g of the partially oxidized sodium alginate prepared in step (2), and stir magnetically at room temper...

Embodiment 2

[0025] (1) Use a balance to weigh 1.9g of sodium alginate and add it to 150g of deionized water, stir it with a magnetic force at 30°C to dissolve completely, add 1.76g of sodium periodate solid, and react in the dark for 48 hours, the temperature is not higher than 30°C, add 0.41g of ethylene glycol was used to terminate the reaction, 150g of ethanol and 3.0g of sodium chloride were added, the layers were statically separated, filtered with suction, and dried in a vacuum oven at 40°C for 48h. Oxidized sodium alginate was obtained.

[0026] (2) Add 0.6 g of sodium alginate, 2.4 g of hydroxymethyl cellulose, and 1.2 g of gelatin into 82.6 g of deionized water with a balance, and stir magnetically at 40° C. until completely dissolved.

[0027] (3) Weigh 3.0 g of 1,2-propanediol and 9.0 g of glycerol, add the system obtained in step (2), and stir to dissolve completely. Weigh 1.2 g of the partially oxidized sodium alginate prepared in step (2), and stir magnetically at room temp...

Embodiment 3

[0030] (1) Use a balance to weigh 1.9g of sodium alginate and add it to 150g of deionized water, stir it with a magnetic force at 30°C to dissolve completely, add 1.76g of sodium periodate solid, and react in the dark for 48 hours, the temperature is not higher than 30°C, add 0.41g of ethylene glycol was used to terminate the reaction, 150g of ethanol and 3.0g of sodium chloride were added, the layers were statically separated, filtered with suction, and dried in a vacuum oven at 40°C for 48h. Oxidized sodium alginate was obtained.

[0031] (2) Add 0.8 g of sodium alginate, 2.1 g of hydroxymethyl cellulose, and 2.1 g of gelatin into 83.6 g of deionized water, and stir magnetically at 40°C until completely dissolved.

[0032] (3) Weigh 1.75g ​​of 1,2-propanediol and 7.84g of glycerol, add the system obtained in step (2), and stir to dissolve completely. Weigh 1.8 g of the partially oxidized sodium alginate produced in step (2), and stir magnetically at room temperature until t...

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Abstract

The invention relates to biodegradable medical hemostasis paper and a preparation method thereof. The preparation method of the biodegradable medical hemostasis paper is characterized by taking materials such as hydroxymethyl cellulose, sodium alginate, oxidized sodium alginate, gelatin and the like, crosslinking the materials to a certain extent to prepare hydrogel, dewatering, performing freeze drying and extruding into a paper sheet shape. The biodegradable medical hemostasis paste has high water absorption and water resistance, also has excellent mechanical property, is free of cytotoxicity, free of stimulation and sensitization on skin, has a rapid hemostasis effect, and can be applied to local hemostasis of surgical and trauma patients.

Description

technical field [0001] The experimental invention relates to a biodegradable medical hemostatic paper and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The invention relates to a degradable biological hemostatic patch with excellent hemostatic function. Specifically, it is made by cross-linking some natural medical polymers, freeze-dried, and extruded, which can be used for local hemostasis of surgical and trauma patients. [0003] In clinical and practical life, there is a great requirement for local hemostasis. Timely hemostasis helps us avoid bacterial and viral infections. In clinical surgery, it helps to reduce the chance of infection by reducing blood transfusion for patients. At present, some commercial products have been put into use in clinical and practical life. Some traditional hemostatic materials have many disadvantages. For example, fibrin glue has a good hemostatic effect, but the configuration ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
Inventor 马贵平陈绍山聂俊
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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