Four-layer coaxial fiber wound dressing and preparation method thereof

A wound dressing and fiber technology, which can be applied in fiber processing, fiber chemical characteristics, cellulose/protein conjugated artificial filaments, etc., can solve the problems of drug burst release phenomenon and short drug release time.

Active Publication Date: 2017-11-28
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the existing nanofiber dressings generally have a short drug r

Method used

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  • Four-layer coaxial fiber wound dressing and preparation method thereof
  • Four-layer coaxial fiber wound dressing and preparation method thereof
  • Four-layer coaxial fiber wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Take 2 g of gelatin, add it to 10 ml of trifluoroethanol solvent, and stir magnetically at room temperature for 9 hours to obtain a solution A with a gelatin mass concentration of 0.2 g / ml;

[0044] (2) Add 2×10 -2 g penicillin, magnetically stirred at room temperature for 3h to obtain solution B, the mass ratio of penicillin and gelatin in solution B is 1 / 100;

[0045] (3) Take 0.5 g of polycaprolactone, add it to 10 ml of trifluoroethanol solvent, and stir magnetically at room temperature for 10 hours to obtain a solution C with a mass concentration of polycaprolactone of 0.05 g / ml;

[0046] (4) Add the gelatin of 1.5g in solution C, magnetically stir at room temperature 9h, the solution D that the total mass concentration that obtains polycaprolactone and gelatin is 0.2g / ml, the mass ratio of polycaprolactone and gelatin in solution D for 25 / 75;

[0047] (5) Add 2×10 to solution D -3 g desferroxamine (DFO), magnetically stirred at room temperature for 6h, to o...

Embodiment 2

[0056] (1) Take 0.5 g of polycaprolactone, add it to 10 ml of trifluoroethanol solvent, and stir magnetically at room temperature for 10 hours to obtain a solution A with a mass concentration of polycaprolactone of 0.05 g / ml;

[0057] (2) Add 1.5g gelatin in solution A, magnetically stir at room temperature 9h, obtain the solution B that the total mass concentration of polycaprolactone and gelatin is 0.20g / ml, the mass ratio of polycaprolactone and gelatin in solution B is 25 / 75;

[0058] (3) Add 0.4g cephalosporin to solution B, stir magnetically at room temperature for 1h to obtain solution C, the ratio of the total mass of cephalosporin to polycaprolactone and gelatin in solution C is 20 / 100;

[0059] (4) Take 1.0 g of polycaprolactone, add it to 9.5 ml of trifluoroethanol solvent, and stir magnetically at room temperature for 10 h to obtain solution D;

[0060] (5) Add 1.0 g of gelatin to solution D, and magnetically stir at room temperature for 9 hours to obtain solution...

Embodiment 3

[0070] (1) Take 0.5 g of polylactic acid, add 10 ml of N,N-dimethylformamide solvent, and magnetically stir at room temperature for 9 hours to obtain solution A with a mass concentration of polylactic acid of 0.02 g / ml;

[0071](2) Add the chitosan of 1.5g in solution C, magnetically stir 10h at room temperature, obtain solution B, the mass ratio of polylactic acid and chitosan in solution B is 25 / 75;

[0072] (3) Add 0.04g tetracycline to solution B, magnetically stir at room temperature for 6h, obtain solution C, the ratio of the quality of tetracycline in solution C to the total mass of polylactic acid and chitosan is 2 / 100;

[0073] (4) Take 1 g of polylactic acid, add 10 ml of N,N-dimethylformamide solvent, and magnetically stir at room temperature for 9 hours to obtain a solution D with a mass concentration of polylactic acid of 0.10 g / ml;

[0074] (5) Add the chitosan of 1g in D solution, magnetically stir 10h at room temperature, obtain solution E, the mass ratio of po...

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Abstract

The invention relates to a four-layer coaxial fiber wound dressing and a preparation method thereof and belongs to the field of biological materials. The material is prepared by adopting a synthetic polymer with biocompatibility and a natural polymer as main raw materials and using a four-layer coaxial needle through an electrostatic spinning method. The fiber has a four-layer coaxial structure, various layers of matrixes load different drugs according to the wound healing mechanism, and the release sequence of the drug can correspond to the wound healing process. The material has excellent biocompatibility and can release the drug in a manner of fitting with the wound healing mechanism.

Description

technical field [0001] The invention relates to a wound dressing with antibacterial, anti-inflammation, and blood vessel-promoting functions and a preparation method thereof, belonging to the field of biological materials. Specifically, it relates to a wound dressing with a four-layer coaxial fiber structure, each layer of matrix is ​​respectively loaded with drugs according to the wound healing mechanism, so that the release sequence of different drugs can correspond to the wound healing process and its preparation method. Background technique [0002] Skin trauma is very common clinically, and the healing of the wound has a great influence on the outcome and recovery of the patient's condition. At present, wound healing is mainly divided into the following five stages, namely, inflammatory response stage, cell proliferation stage, connective tissue formation stage, wound contraction stage, and wound reconstruction stage. The main application period of wound dressings is i...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/40A61L15/26A61L15/28A61L15/32D01D5/00D04H1/728D01D5/30D01F8/14D01F8/02D01F8/18D01F1/10
CPCA61L15/26A61L15/28A61L15/32A61L15/325A61L15/40A61L15/44A61L2300/404A61L2300/41A61L2300/412A61L2300/414D01D5/0015D01D5/0076D01D5/30D01F1/10D01F1/103D01F8/02D01F8/14D01F8/18D04H1/728C08L89/00C08L67/04C08L5/08
Inventor 张立群池骋石锐宫敏
Owner BEIJING UNIV OF CHEM TECH
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