Method for efficiently preparing high molecular material thickening system

A kind of polymer material and polymer technology, which is applied in the field of high-efficiency preparation of polymer material thickening system, can solve the problems affecting the guarantee of product quality, the deviation of thickener feeding amount, and inconvenient operation, so as to achieve the improvement of production efficiency and product quality. Good, easy to operate effect

Inactive Publication Date: 2017-12-08
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Second, it is difficult to avoid lumps and hard cores in the colloid.
[0010] The third is that it is necessary to increase the device, which is inconvenient to operate
[0011] Filtration transfer requires the addition of filtration devices, power for suction filtration/press filtration, addition of batching tanks and other equipment, an

Method used

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  • Method for efficiently preparing high molecular material thickening system
  • Method for efficiently preparing high molecular material thickening system
  • Method for efficiently preparing high molecular material thickening system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Traditional process and process contrast of the present invention-operation method, preparation time and result contrast

[0033] 3% xanthan gum-10% glycerin-water solution thickening system preparation

[0034] 1. Experimental method

[0035] The traditional craft preparation method is:

[0036] (1) Add 100g of glycerin into 870g of purified water, stir and mix;

[0037] (2) Sprinkle 30g of xanthan gum into it slowly while stirring, and continue to stir until the hydration is completely uniform and there are no visible particles and lumps, and no hard core.

[0038] In step (2), it is advisable to choose a preparation tank with a larger diameter to increase the spread area of ​​the polymer substance on the liquid surface and increase its chance of contact with the solvent. The entire dissolving process takes 2-3 hours, and stirring should be continued during this period And pay attention to remove the xanthan gum adhering to the container wall and the s...

Embodiment 2

[0053] Embodiment 2 Comparison of traditional process and process of the present invention-screen retention result and viscosity retention situation comparison

[0054] The preparation method of the traditional process and the process method of the present invention is the same as in Example 1. The results are as follows

[0055] Table 1 Comparison of sieve retention results and viscosity retention

[0056] Compare items

Embodiment 3

[0057] Embodiment 3 traditional process and the process contrast of the present invention---consistency contrast between batches

[0058] The preparation method of the traditional process and the process method of the present invention is the same as in Example 1. The results are as follows

[0059] Table 2 Consistency comparison between batches

[0060]

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PUM

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Abstract

The invention provides a method for efficiently preparing a high molecular material thickening system. Before a solvent is used for dissolving or swelling a high molecular thickening substance, the high molecular thickening substance and another medium are fully premixed to obtain a premix, wherein the medium is a substance which can be mixed and dissolved with the solvent of a high molecular material but can not swell or dissolve the high molecular thickening substance. The method has the advantages of being less in time consumption, reduced in energy consumption, good in product quality, capable of avoiding occurrence of agglomerates and hard cores in colloids, free of filtration, convenient to operate, capable of realizing expanded production easily, and adaptive to operation demands of industrialization production.

Description

technical field [0001] The invention relates to a method for efficiently preparing a polymer material thickening system, which is suitable for preparing various viscous liquids and semi-solid products containing polymer materials. Background technique [0002] A large part of the various products involved in medicine, food and cosmetics are suspension products, and their physical form is often viscous liquid or semi-solid with certain fluidity. In order to stabilize the physical stability of the formulation system, the particle size of the active ingredient and other indicators, and ensure that the quality of the product does not change within the validity period, it is usually necessary to add a thickener as a suspending agent to the formulation. [0003] Suspension-type pharmaceutical preparations can not only ensure the stability of the active substance of the drug (the physical stability of the drug system of the suspension-type preparation), but also ensure that the act...

Claims

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Application Information

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IPC IPC(8): A23L29/20A23L29/269A23L29/256A23L29/262A23L29/288A61K47/36A61K47/38A61K47/10A61K8/73A61K8/34A61Q19/00C08J3/05C08L5/00C08L1/28C08L71/08
CPCA23V2002/00A61K8/34A61K8/345A61K8/73A61K8/731A61K47/10A61K47/36A61K47/38A61K2800/10A61K2800/48A61Q19/00C08J3/05C08J2301/28C08J2305/00C08J2371/00C08L1/286C08L5/00C08L71/00A23V2250/082A23V2250/086C08L1/284
Inventor 张莉徐宏杨
Owner CHONGQING HUAPONT PHARMA
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