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Marine active peptide/chitosan burn ointment and preparation method thereof

A chitosan, burn and scald technology, applied in the field of biomedical materials, can solve the problems of long treatment cycle, slow effect, high price, etc., achieve the effects of non-toxic side effects, delay aging, and solve environmental problems

Active Publication Date: 2018-12-21
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To solve the problems of long treatment cycle, easy infection, slow effect and high price of the existing burn ointment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Add tilapia skin collagen peptide and chitosan into deionized water, fully dissolve and filter through a 0.45 μm filter membrane to obtain component A;

[0037] (2) Melt beeswax in a water bath at 50°C, add vegetable oil to obtain component B;

[0038] (3) Mix components A and B, add glycerin, and sterilize with ethylene oxide to obtain marine active peptide / chitosan burn ointment, which is stored at 4°C for later use.

[0039] The molecular weight of tilapia skin collagen peptide is 3KDa, the molecular weight of chitosan is 1KDa, and the degree of deacetylation is 95%;

[0040] The dosage (grams) of each component is as follows:

[0041] A component + B component 5, where A: B = 1: 10

[0042] Glycerin (analytical grade) 1

[0043] A component mass parts composition is as follows

[0044] Tilapia Skin Collagen Peptides 10

[0045] Chitosan 2

[0046] Deionized water 30

[0047] The mass composition of component B is as follows

[0048] beeswax 1

[0049] s...

Embodiment 2

[0051] (1) Add tilapia skin collagen peptide and chitosan into deionized water, fully dissolve and filter through a 0.45 μm filter membrane to obtain component A;

[0052] (2) Melt beeswax in a water bath at 80°C, add vegetable oil to obtain component B;

[0053] (3) Mix components A and B, add glycerin, and sterilize with ethylene oxide to obtain marine active peptide / chitosan burn ointment, which is stored at 4°C for later use.

[0054] The molecular weight of tilapia skin collagen peptide is 1KDa, the molecular weight of chitosan is 3KDa, and the degree of deacetylation is 85%;

[0055] The dosage (grams) of each component is as follows:

[0056] A component + B component 10, wherein, A: B = 1: 5

[0057] Glycerin (analytical grade) 1

[0058] in:

[0059] A component mass parts composition is as follows

[0060] Tilapia Skin Collagen Peptides 2

[0061] Chitosan 10

[0062] Deionized water 10

[0063] The mass composition of component B is as follows

[0064] bees...

Embodiment 3

[0067] (1) Add tilapia skin collagen peptide and chitosan into deionized water, fully dissolve and filter through a 0.45 μm filter membrane to obtain component A;

[0068] (2) Melt beeswax in a water bath at 60°C, add vegetable oil to obtain component B;

[0069] (3) Mix components A and B, add glycerin, and sterilize with ethylene oxide to obtain marine active peptide / chitosan burn ointment, which is stored at 4°C for later use.

[0070] The molecular weight of tilapia skin collagen peptide is 2KDa, the molecular weight of chitosan is 2KDa, and the degree of deacetylation is 90%;

[0071] The dosage (grams) of each component is as follows:

[0072] A component + B component 7, where, A:B= 1:8

[0073] Glycerin (analytical grade) 1

[0074] in:

[0075] A component mass parts composition is as follows

[0076] Tilapia Skin Collagen Peptides 6

[0077] Chitosan 6

[0078] Deionized water 20

[0079] The mass composition of component B is as follows

[0080] beeswax 1

...

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Abstract

The invention relates to a seafood bioactive peptide / chitosan burning and scald ointment and a preparation method thereof. The preparation method comprises the following steps: (1) putting tilapia mossambica skin collagen peptide and chitosan into deionized water, sufficiently dissolving, and filtering so as to obtain a component A; (2) melting beewax in a water bath of 50-80 DEG C, and adding plant oil so as to obtain a component B; and (3) mixing the component A and the component B, adding glycerinum, and sterilizing, thereby obtaining the seafood bioactive peptide / chitosan burning and scald ointment. The burning and scald ointment provided by the invention is capable of accelerating healing of burning and scald wounds and regeneration of skin tissue, is free of toxic or side effect, and in addition is capable of healing wounds rapidly.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a marine active peptide / chitosan burn ointment and a preparation method thereof. Background technique [0002] Various burns, scalds, wounds and other skin injuries are common clinical diseases. So far, skin wounds caused by various reasons and the scar tissue formed by healing still seriously threaten human health and quality of life. Therefore, the development of preparations or dressings that can accelerate the healing of burn wounds and help the wound tissue to be repaired both structurally and functionally has always been an important and difficult point in the field of wound therapy. At present, there are various external dressings for burns and scalds, but most of them belong to the hydrogel type. Most of the commercially available burns and scald dressings have the characteristics of high price, long treatment cycle, susceptibility to infection, and slow effect. Con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/01A61K9/06A61K47/10A61P17/02C12P21/06A61K31/722A61K35/644A61K36/185
CPCA61K9/06A61K31/722A61K35/644A61K36/185A61K38/014A61K47/10C07K14/78C12P21/06A61K2300/00
Inventor 李思东欧阳茜茜胡章陈法锦黄娜孔松芝李普旺杨子明李程鹏李高荣颜婷婷钟庆坤罗荣琼
Owner GUANGDONG OCEAN UNIVERSITY
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