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Biological marker for detecting gastric cancer and application of biological marker

A technology of gastric cancer and detection kit, which is applied in the field of detection of biomarkers of gastric cancer, and can solve problems such as the undetermined role of intestinal microbiota

Active Publication Date: 2017-12-08
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of the gut microbiota in gastric carcinogenesis has not been established

Method used

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  • Biological marker for detecting gastric cancer and application of biological marker
  • Biological marker for detecting gastric cancer and application of biological marker
  • Biological marker for detecting gastric cancer and application of biological marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Materials and Methods:

[0043] 1. Patient Sample Collection and Cell Culture

[0044] Stool samples were obtained from 73 volunteers [35 from routine physical examination population controls and 38 from gastric cancer patients hospitalized in Shandong Provincial Hospital (Jinan, Shandong)]. All volunteers obtained informed consent before inclusion in the study. Fecal samples were kept in a -80°C freezer for subsequent analytical studies. All studies were approved by the Ethics Committee of Shandong University (Jinan, Shandong). Human colorectal cell line HT-29 cells were cultured in a medium containing 10% FCS (Tianhang Co., Ltd., Hangzhou, China) and 1% penicillin-streptomycin.

[0045] 2.16S sequencing

[0046] (1) Genomic DNA extraction

[0047] Fecal total DNA was extracted using the CTAB / SDS method. DNA concentration and purity were monitored on a 1% agarose gel. Depending on the concentration, DNA was diluted to 1 ng / μl with sterile water.

[0048] (2) Am...

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PUM

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Abstract

The invention discloses a biological marker for detecting a gastric cancer and an application of the biological marker. The biological marker represents that enteric micropopulation plays a crucial role in adjusting inflammation and the gastric cancer; a desulfaovibrio affiliated bacterium can effectively serve as a detection marker and a treatment target spot of the gastric cancer; and the gastric cancer can be easily and reliably detected by the marker.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically, the invention relates to a biomarker for detecting gastric cancer and its application. Background technique [0002] Gastric cancer is one of the most common malignancies, accounting for about 10% of all invasive cancers worldwide and ranking second among all cancer-related deaths. Although the incidence of gastric cancer has decreased in the West, gastric cancer is still common in Asia, especially China. The incidence and mortality of gastric cancer are increasing with increasing population changes, therefore, there is an urgent need to find more effective diagnostic methods and treatments. Although the pathogenesis of gastric cancer is unknown, exposure to environmental carcinogens, such as toxic chemicals and Helicobacter pylori, has been shown to increase cancer risk. Current knowledge cannot explain why only some patients with superficial gastritis develop atroph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/06A61K45/00A61P35/00C12R1/63
CPCA61K45/00C12Q1/06G01N2800/06
Inventor 刘世利韩明勇迟洪波戴建建宋宁
Owner SHANDONG UNIV
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