Application of hoxa9 gene in preparation of medicine for treating skin squamous cell carcinoma

Abstract

The invention discloses the application of HOXA9 gene in the preparation of medicine for treating skin squamous cell carcinoma, belonging to the field of gene therapy. After two years of experimental research, the inventor and his entire team took the cell line A431, which is characteristic of skin squamous cell carcinoma, as the experimental object. Through experiments, they found that the targeted up-regulation of HOXA9 can inhibit the proliferation, migration and invasion of tumor cells, and inhibit the tumor cell proliferation. Glycolysis, ultimately improving or treating squamous cell carcinoma of the skin. The present invention provides a new method for treating CSCC on the basis of ensuring organ function intact and beautiful appearance to the greatest extent, can overcome the deficiencies of the prior art, and has great significance.

Description

technical field [0001] The invention belongs to the field of gene therapy, in particular to the application of HOXA9 gene in the preparation of medicines for treating skin squamous cell carcinoma. Background technique [0002] Cutaneous squamous cell carcinoma (CSCC) is a type of malignant tumor originating from the keratinocytes of the epidermal appendages. It is one of the most common skin malignancies in clinical practice. 20% of skin malignancies. In my country, the high incidence age of CSCC is 50-60 years old, and it is more common in exposed positions such as the head, neck, hands and forearm extension. The etiology of CSCC is complex, and long-term ultraviolet radiation is its biggest risk factor. In addition, human papillomavirus (HPV) 16, 18 and 31 infection, organ transplantation, chemical agents and other factors are closely related to its pathogenesis. Although the mortality rate of CSCC is not high, it has a strong ability to metastasize and invade, and can ...

AI Technical Summary

Problems solved by technology

In view of the fact that the operation of the traditional treatment method needs to expand the scope of resection to the surrounding tissue of the tumor, it is likely to cause damage to the function of the epidermis and subcutaneous tissue and affect the appearance of the organ. At the same time, the high recurrence rate of this method also makes it necessary to find a method that can maximize the protection of the organ. New methods of treating CSCC on the basis of intact function and beautiful appearance are imperative

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