A purification method for preparing a codeine standard substance used for forensic scientific drug detection

A standard substance and scientific technology, applied in the field of preparation of forensic drug standard substances, can solve the problems affecting the accuracy of quantitative results, restricting traceability and mutual recognition, lack of drug standard substances, etc., to improve the quality of analysis and measurement and ensure the effectiveness , the effect of effective mutual recognition

Active Publication Date: 2017-12-15
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Abstract
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Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.
Moreover, the lack of domestic drug standard substances has beco

Method used

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  • A purification method for preparing a codeine standard substance used for forensic scientific drug detection
  • A purification method for preparing a codeine standard substance used for forensic scientific drug detection
  • A purification method for preparing a codeine standard substance used for forensic scientific drug detection

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Embodiment Construction

[0034] In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0035] In this example, the codeine samples seized in the case were mainly used to optimize and screen the experimental conditions for separation and purification of codeine by preparative liquid chromatography.

[0036] 1. Instruments, reagents and materials

[0037] 1.1 Main Instruments

[0038] Analytical high-performance liquid chromatography (Shimadzu, Japan), including: LC-20AD high-pressure infusion pump; SIL-10A autosampler; SPD-20A diode array detector; CTO-20A column thermostat.

[0039] Preparative high-perfor...

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Abstract

A purification method for preparing a codeine standard substance used for forensic scientific drug detection is disclosed. The method includes (1) detecting codeine purities of seized codeine samples, and selecting the codeine sample as a raw material for preparing the codeine standard substance; and (2) preparing the codeine standard substance by utilizing high performance liquid chromatography. The obtained codeine obtained by the method is validated by nuclear magnetic resonance, liquid chromatography-tandem mass spectrometry and infrared spectroscopy analysis, the purity value of the codeine obtained by the method is determined by liquid chromatography and gas chromatography, impurities not responding to chromatography are measured, and according to standard substance development requirements, stability, uniformity, the fixed value and total uncertainty estimation of the prepared codeine standard substance all meet related regulations, thus meeting excepted indexes.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing codeine standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measurement technology ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 郑珲高利生苏福海李红梅戴新华张春水常颖赵阳贺剑锋翟晚枫李彭赵彦彪刘克林钱振华郑晓雨杨虹贤
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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