Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Three-dimensional artificial total intervertebral disc as well as preparation method and applications thereof

A technology of full intervertebral disc and intervertebral disc, which is applied in the field of three-dimensional artificial full intervertebral disc, can solve problems such as uncontrollability of electrospinning jet, and achieve the effect of good biocompatibility

Inactive Publication Date: 2017-12-22
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
View PDF9 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the uncontrollability of the electrospinning jet, most of the nanofiber scaffolds prepared by traditional methods are in the form of non-woven fabrics with random arrangement of fiber directions. Anisotropic fibrous annulus composed of ordered arrays remains a challenging problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Three-dimensional artificial total intervertebral disc as well as preparation method and applications thereof
  • Three-dimensional artificial total intervertebral disc as well as preparation method and applications thereof
  • Three-dimensional artificial total intervertebral disc as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] This example is used to illustrate the preparation method of the PPC-I intervertebral disc of the present invention.

[0073] According to the mass ratio of PCL: PLGA: Collagen of 4: 2: 1, 1 g was dissolved in 10 mL of hexafluoroisopropanol to prepare 10% pre-spinning solution, and then spun according to the method of Example 1 to prepare ordered and disordered PPC -I spinning. Spinning was performed at a 17G needle with a voltage of 15kV and a liquid feeding speed of 1mL h-1. We use a static collection device to prepare random spinning, using a line speed of 13 m s -1 High-speed rotating roller collection device to prepare orderly spinning. Then cut the ordered spinning obtained according to the above steps into strips, so that the spinning arrangement direction and the long axis of the strips are + / -30° long strips, and then the +30° and -30° two-layer spinning The silk films are stacked and then rolled up around a circular shaft to form a multi-layer concentric ri...

Embodiment 2

[0076] This example is used to illustrate the preparation method of the PPC-II intervertebral disc of the present invention.

[0077] According to the mass ratio of PCL: PLGA: Collagen of 2: 2: 1, 1 g was dissolved in 10 mL of hexafluoroisopropanol to prepare 10% pre-spinning liquid, and then spinning according to the method of Example 1 to prepare ordered and disordered PPC -II spinning. Apply voltage 15kV to 17G needle, 1mL h -1 The liquid feeding speed is used for spinning. We use a static collection device to prepare random spinning, using a line speed of 13 m s -1 High-speed rotating roller collection device to prepare orderly spinning. Then cut the ordered spinning obtained according to the above steps into strips, so that the spinning arrangement direction and the long axis of the strips are + / -30° long strips, and then the +30° and -30° two-layer spinning The silk films are stacked and then rolled up around a circular shaft to form a multi-layer concentric ring str...

Embodiment 3

[0080] This example is used to illustrate the preparation method of the PPC-III intervertebral disc of the present invention.

[0081] According to the mass ratio of PCL: PLGA: Collagen 3: 3: 1, 1 g was dissolved in 10 mL of hexafluoroisopropanol to prepare 10% pre-spinning solution, and then spinning according to the method of Example 1 to prepare ordered and disordered PPC -III spinning. Apply voltage 15kV to 17G needle, 1mL h -1 The liquid feeding speed is used for spinning. We use a static collection device to prepare random spinning, using a line speed of 13 m s -1High-speed rotating roller collection device to prepare orderly spinning. Then cut the ordered spinning obtained according to the above steps into strips, so that the spinning arrangement direction and the long axis of the strips are + / -30° long strips, and then the +30° and -30° two-layer spinning The silk films are stacked and then rolled up around a circular shaft to form a multi-layer concentric ring str...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a three-dimensional artificial total intervertebral disc as well as a preparation method and applications of the three-dimensional artificial total intervertebral disc. According to the technical scheme, a spun membrane with high hydrophilicity, high water retention and high biocompatibility is prepared by blending PLGA, PCL and collagen. The three-dimensional artificial total intervertebral disc provided by the invention can simulate a micro-nano structure in the body, and also has good biocompatibility, the ordered nano fibers on the experimented surfaces of cells can induce directional orientation and growth of the cells, the artificial intervertebral disc implanted into the experimented surfaces of animals can be effectively combined together with surrounding tissues, so that a mechanical activity unit capable of freely moving is formed.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a three-dimensional artificial total intervertebral disc, its preparation method and application. Background technique [0002] Chronic neck and lower back pain is a disease with a very high incidence rate, and huge sums of money are spent on the treatment of diseases caused by intervertebral disc lesions every year. According to statistics, more than 97% of individuals over the age of 50 suffer from varying degrees of neck and back pain. The most common pain in the waist and neck is closely related to lesions in the intervertebral disc, mainly caused by lesions in the intervertebral disc. The current treatment for degenerative disc disease includes conservative treatment (drugs and physiotherapy) to surgical treatment (discectomy, spinal fusion and disc replacement). However, these treatments can relieve pain or restore some functions of the intervertebral disc, but canno...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/44A61L27/18A61L27/24A61L27/20A61L27/02A61L27/50
CPCA61F2/442A61F2/30942A61F2002/30963A61F2002/4495A61L27/025A61L27/18A61L27/20A61L27/24A61L27/50A61L2400/12A61L2430/38C08L67/04C08L5/04
Inventor 蒋兴宇杨俊川
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com