Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antipyretic and analgesic ibuprofen sustained-release capsule composition and preparation method thereof

A technology of antipyretic, analgesic and slow-release capsules, which is applied in the field of medicine, can solve the problems of large dosage of ibuprofen, and achieve the effects of low toxic and side effects, good tolerance and high drug dependence

Inactive Publication Date: 2017-12-22
NANJING ZHENGKUAN MEDICAL TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Purpose of the invention: Aiming at the problem that the amount of ibuprofen in ordinary ibuprofen sustained-release capsules is relatively large, the present invention provides a low-dose ibuprofen sustained-release capsule composition for antipyretic and analgesic and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antipyretic and analgesic ibuprofen sustained-release capsule composition and preparation method thereof
  • Antipyretic and analgesic ibuprofen sustained-release capsule composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: get ibuprofen 200g, tulobuterol hydrochloride 100g, blank ball core 60g, carboxymethyl cellulose 30g, carboxymethyl starch sodium 20g and magnesium stearate 5g, preparation method comprises the steps: adopt centrifugal To prepare granules by granulation, pour the blank core into the centrifugal granulator, turn on the centrifugal turntable, set the speed to 100-120rpm, turn on the peristaltic pump, adjust the atomization pressure, spray ethanol, and sprinkle ibuprofen and hydrochloric acid at the same time Tulobuterol, carboxymethyl cellulose, and sodium carboxymethyl starch are used for drug application. After the drug application is completed, the pellets are dried, and the pellets between 16 mesh and 26 mesh are taken, and magnesium stearate is added. Carry out capsule filling, then aluminum-plastic packaging gets final product.

Embodiment 2

[0018] Embodiment 2: get ibuprofen 200g, tulobuterol hydrochloride 200g, blank ball core 60g, polyvinylpyrrolidone 30g, croscarmellose sodium 20g and magnesium stearate 5g, preparation method comprises the steps: using To prepare granules by centrifugal granulation, pour the blank core into the centrifugal granulator, turn on the centrifugal turntable, set the speed at 100-120rpm, turn on the peristaltic pump, adjust the atomization pressure, spray ethanol, and sprinkle ibuprofen, Tulobuterol hydrochloride, polyvinylpyrrolidone, and croscarmellose sodium are used for drug application. After the drug application is completed, the pellets are dried, and the pellets between 16 mesh and 26 mesh are taken, and stearic acid is added. Magnesium, for capsule filling and then aluminum-plastic packaging.

Embodiment 3

[0019] Embodiment 3: get ibuprofen 200g, tulobuterol hydrochloride 150g, blank ball core 60g, hydroxypropyl methylcellulose 30g, crospovidone 20g and magnesium stearate 5g, the preparation method comprises the following steps: Prepare granules by centrifugal granulation method, pour the blank core into the centrifugal granulator, turn on the centrifugal turntable, set the speed at 100-120rpm, turn on the peristaltic pump, adjust the atomization pressure, spray ethanol, and sprinkle ibuprofen at the same time , tulobuterol hydrochloride, hydroxypropyl methylcellulose, and crospovidone are used for drug application. After the drug application is completed, the pellets are dried, and the pellets between 16 mesh and 26 mesh are taken, and hard Magnesium fatty acid, capsule filling, and then aluminum-plastic packaging.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an antipyretic and analgesic ibuprofen sustained-release capsule composition. The antipyretic and analgesic ibuprofen sustained-release capsule composition comprises ibuprofen and tulobuterol hydrochloride. The active components of the capsule composition are composed of ibuprofen and tulobuterol hydrochloride; and a corresponding preparation method is employed. The capsule composition has synergistic antipyretic effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antipyretic and analgesic ibuprofen sustained-release capsule composition and a preparation method thereof. Background technique [0002] Antipyretic and analgesic drugs are a class of drugs that have antipyretic and analgesic pharmacological effects, as well as significant anti-inflammatory and anti-rheumatic effects. Therefore, this class of drugs is also called antipyretic, analgesic and anti-inflammatory drugs. In view of the fact that its anti-inflammatory effect is different from that of glucocorticoids, since 1974, these drugs have been classified as non-steroidal anti-inflammatory drugs internationally. Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/192A61K31/137A61K47/32A61K47/38A61P29/00
CPCA61K9/0002A61K9/1635A61K9/1652A61K9/1676A61K31/137A61K31/192A61K2300/00
Inventor 李洋
Owner NANJING ZHENGKUAN MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com