Ion chromatographic column preparation method which is semi-automatic and controlled by computer

An ion chromatographic column, semi-automated technology, applied in the field of ion chromatographic column preparation, can solve the problems of large separation performance of chromatographic column fillers, cumbersome preparation process of chromatographic column, and labor cost of using reagents, so as to reduce the harm to human body and environment, Good reproducibility and reduced usage

Inactive Publication Date: 2017-12-22
ANHUI WAYEE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention aims to solve the problems of cumbersome preparation process of the above-mentioned traditional chromatographic column, complex method, large use of reagents and high labor cost, large difference in separation performance of different batches of chromatographic column fillers, poor reproducibility, etc.

Method used

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  • Ion chromatographic column preparation method which is semi-automatic and controlled by computer
  • Ion chromatographic column preparation method which is semi-automatic and controlled by computer
  • Ion chromatographic column preparation method which is semi-automatic and controlled by computer

Examples

Experimental program
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Embodiment 1

[0026] A semi-automatic and computer-controlled ion chromatography column preparation method, comprising the following four steps:

[0027] (1) Mix 3.5g of 10 micron PS / DVB microspheres with concentrated sulfuric acid at a volume ratio of 1:13, stir and react at 80°C for 2 hours, wash with ultrapure water until neutral, and obtain sulfonated microspheres. Disperse the thawed microspheres into water, and quickly pour them into a homogenization tank (connected to the column tube above) after ultrasonication for 10 minutes, pressurize to 20MPa and keep for 2 hours, replenish replacement water in time, and continue to rinse with ultrapure water for 30 minutes after the end.

[0028] (2) Prepare the following raw materials:

[0029] A: 0.3M mixed aqueous solution of 1,4-butanediol diglycidyl ether and methylamine; B: ultrapure water; C: 0.5M aqueous solution of 1,4-butanediol diglycidyl ether; D: 1.0 M methylamine aqueous solution.

[0030] (3) Connect the column tube containing ...

Embodiment 2

[0041] A semi-automatic and computer-controlled ion chromatography column preparation method, comprising the following four steps:

[0042] (1) Mix 3.5g of 10 micron PS / DVB microspheres with concentrated sulfuric acid at a volume ratio of 1:13, stir and react at 80°C for 2 hours, wash with ultrapure water until neutral, and obtain sulfonated microspheres. Disperse the thawed microspheres into water, and quickly pour them into a homogenization tank (connected to the column tube above) after ultrasonication for 10 minutes, pressurize to 20MPa and keep for 2 hours, replenish replacement water in time, and continue to rinse with ultrapure water for 30 minutes after the end.

[0043] (2) Types and concentrations of raw materials required for the preparation of chromatographic column packing:

[0044] A: 0.3M mixed aqueous solution of 1,4-butanediol diglycidyl ether and methylamine; B: ultrapure water; C: 0.5M aqueous solution of 1,4-butanediol diglycidyl ether; D: 1.0 M trimethyla...

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Abstract

The invention provides an ion chromatographic column preparation method which is semi-automatic and controlled by a computer. The preparation method of a chromatographic column filler provided by the invention is simple and convenient in operation, and automatic synthesis can be realized after preparation of relevant solutions, so that manpower cost is reduced. Because the operation parameters of a quaternary pump system are controlled by a computer all along, reactions of each process are controlled very precisely, and fillers of different batches have similar properties and good reproducibility. The usage amount of chemical reagents is greatly reduced, and harm of experiment processes to human bodies and environment is reduced, so that the preparing method provided by the invention is much better than conventional artificial chemical synthesis methods.

Description

technical field [0001] The invention relates to the field of ion chromatographic column preparation, in particular to a semi-automatic and computer-controlled ion chromatographic column preparation method. Background technique [0002] Ion Chromatography (IC) is a type of high-performance liquid chromatography (HPLC), and it is a liquid chromatography method for analyzing ions. Ion chromatography is a method for separation by exchanging charged solute molecules with exchangeable ions on an ion-exchange stationary phase. This method mainly relies on the interaction between charges, and uses the small difference in charges in charged molecules to separate, and has a high separation capacity. . Today, ion chromatography has developed into a well-established chromatographic technique for the analysis of anions and cations. As a fast and sensitive analysis method, ion chromatography is often the first choice for analyzing ionic samples, such as ASTM (American Society for Testi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/36B01D15/20B01J20/26G01N30/02
CPCB01D15/20B01D15/361B01J20/265G01N30/02
Inventor 刘世江裴波
Owner ANHUI WAYEE SCI & TECH CO LTD
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