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Copper (ii) complex constructed by ibuprofen and quinoline-8-formaldehyde Schiff base and its synthesis method and application

A synthesis method and complex technology, which is applied in the field of medicine, can solve problems such as no synthesis method and achieve good proliferation inhibitory activity

Inactive Publication Date: 2019-04-30
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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At present, there is no relevant report on the copper (II) complex constructed by ibuprofen and quinoline-8-formaldehyde salicylhydrazone Schiff base and its synthesis method and application

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  • Copper (ii) complex constructed by ibuprofen and quinoline-8-formaldehyde Schiff base and its synthesis method and application
  • Copper (ii) complex constructed by ibuprofen and quinoline-8-formaldehyde Schiff base and its synthesis method and application
  • Copper (ii) complex constructed by ibuprofen and quinoline-8-formaldehyde Schiff base and its synthesis method and application

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Experimental program
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Embodiment 1

[0039] Take the ligand L2 and [Cu(L1) of the amount (1.0mmol) of equal substance 2] placed in a 50ml round bottom flask, then add 20ml of methanol, stir at room temperature for 24h, filter, collect the filtrate in a 50ml beaker, seal with plastic wrap, then pierce small holes on the plastic wrap, volatilize at room temperature, and obtain a block after one week Dark green crystals, yield 80%.

[0040] The obtained crystal of this embodiment carries out X-ray single crystal diffraction, infrared spectrum and high-resolution mass spectrometry analysis, and its collection of illustrative plates is respectively as follows figure 1 , figure 2 with image 3 As shown, therefore, it can be determined that the blocky dark green crystals obtained are [Cu(L1)(L2)] of the present invention, wherein L1 is ibuprofen with a negative charge of one unit; L2 is quinoline- 8-Formaldehyde salicylhydrazone Schiff base, with a negative charge of one unit.

Embodiment 2

[0046] Example 1 was repeated except that the solvent was changed to ethanol. After ten days, massive dark green crystals were obtained with a yield of 78%.

[0047] Carry out X-ray single crystal diffraction, infrared spectrum and high-resolution mass spectrometry analysis to the crystal obtained in this embodiment, can confirm that the block dark green crystal of gained is [Cu(L1)(L2)] described in the present invention, wherein, L1 is ibuprofen with one unit of negative charge; L2 is quinoline-8-formaldehyde salicylhydrazone Schiff base with one unit of negative charge.

Embodiment 3

[0049] Repeat Example 1, the difference is that the solvent is changed to a mixed solvent composed of methanol and methylene chloride (volume ratio is 4:1), and the total amount of solvent used remains unchanged. One week later, massive dark green crystals were obtained with a yield of 75%.

[0050] Carry out X-ray single crystal diffraction, infrared spectrum and high-resolution mass spectrometry analysis to the crystal obtained in this embodiment, can confirm that the block dark green crystal of gained is [Cu(L1)(L2)] described in the present invention, wherein, L1 is ibuprofen with one unit of negative charge; L2 is quinoline-8-formaldehyde salicylhydrazone Schiff base with one unit of negative charge.

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Abstract

The invention discloses a copper (II) complex constructed from ibuprofen and quinoline-8-formaldehyde Schiff base, and a synthesis method and an application of same. The copper (II) complex has the following chemical formula [Cu(L1)(L2)(NO3)], wherein the L1 refers to ibuprofen and carries one unit of negative charge; the L2 refers to quinoline-8-formaldehydesalicylhydrazone Schiff base and carries one unit of negative charge. The complex belongs to monoclinic crystal system and has C2 / c space groups; cell parameters are described as follows: alpha = 90.00 degrees, beta = 101.695(6) degrees and gamma = 90.00 degrees. The complex has excellent inhibition effect on various tumor cell beads and has potential medicinal value. The complex is hopeful to be applied to preparation of antitumor drugs.

Description

technical field [0001] The invention relates to a copper (II) complex constructed by ibuprofen and quinoline-8-formaldehyde Schiff base, a synthesis method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Copper is an essential trace element in the human body and participates in many biological pathways in living organisms. A large number of experiments have proved that the metabolism of copper in living organisms seriously affects tumor diseases. In recent years, the study of copper complexes as antitumor drugs has increasingly become a hot topic in the field of medicinal chemistry, and a large number of copper complexes have been studied and evaluated for their anticancer activities in vitro and in vivo. [0003] Ibuprofen (2-(-4-isobutylphenyl)propionic acid) is a potent non-steroidal analgesic anti-inflammatory drug that is widely used in the treatment of various inflammatory diseases. At present, there is no relate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08A61P35/00
CPCC07B2200/13C07F1/005
Inventor 胡坤梁福沛邹华红
Owner GUANGXI NORMAL UNIV
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