A kind of opaque polymeric resin and its application in serum separating gel

A technology for serum separation gel and polymer resin, which is applied in the field of serum separation gel and its preparation, can solve the problems of poor compatibility, prone to phase separation and the like, and achieves the effects of moderate initiating activity, easy rate control and high monomer conversion rate.

Active Publication Date: 2019-10-08
湖北新德晟材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to change the deficiencies and shortcomings of existing products on the market, the purpose of the present invention is to solve the problems of poor compatibility and easy phase separation when a variety of macromolecular polymers are mixed to prepare separation gel in the prior art. ; At the same time, organic fluorosilicon is used to modify styrene and acrylate to make it more hydrophobic, and the cross-linking between molecules makes the performance of the polymer resin more stable, effectively solving the problem of ACD liquid pipe, PRP pipe (PRP pipe The composition of the additive is the same as that of the ACD solution), the problems of brine stability and acid-base stability during the storage of trisodium citrate tubes

Method used

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  • A kind of opaque polymeric resin and its application in serum separating gel
  • A kind of opaque polymeric resin and its application in serum separating gel
  • A kind of opaque polymeric resin and its application in serum separating gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0036] Example 2: Preparation of opaque polymer resin

[0037] Put 275g of heptane into the reactor and heat to 65-70℃; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 20.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the composition of the mixed liquid, stir and mix uniformly and AIBME is completely dissolved to form mixed liquid A. Add mixed liquid A dropwise to the reaction kettle, control the dripping rate of mixed liquid A, and control the dripping process in 2.35h. The temperature of the reaction solution is 65-70℃; after the addition is completed, the temperature rises, and the temperature of the reaction solution is controlled between 70-75℃ and the temperature is kept for 0.5h; after the temperature is over, 1.5g AIBME is added to the 12.5g dodecafluoromethacrylate In the mixed liquid composed of heptyl ester and 17.5g vinyl trimethoxysilane, stir and mix until the AIBME is completely dissolved to form mixed liquid B, and then mixed liquid B...

Embodiment 3

[0038] Example 3: Preparation of opaque polymer resin

[0039] Put 275g of heptane into the reactor and heat to 65-70℃; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 25.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the composition of the mixed liquid, stir and mix until the AIBME is completely dissolved to form mixed liquid A. Add the mixed liquid A dropwise to the reaction kettle and control the dropping rate of the mixed liquid A. The dropping is completed in 2.4 hours, and the dropping process is controlled. The temperature of the reaction solution is 65-70°C; after the dropping is completed, the temperature is increased, and the temperature of the reaction solution is controlled to be between 70-75°C and kept for 0.5h; after the temperature is over, 1.5g AIBME is added to the 12.5g dodecafluoromethacrylate In the mixed liquid composed of heptyl ester and 17.5g vinyl trimethoxysilane, stir and mix until the AIBME is completely dissolved to form...

Embodiment 4

[0040] Example 4: Preparation of opaque polymer resin

[0041] Put 275g of heptane into the reactor and heat to 65-70℃; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 25.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the composition of the mixed liquid, stir and mix uniformly and AIBME is completely dissolved to form mixed liquid A, add mixed liquid A dropwise to the reaction kettle, control the dripping rate of mixed liquid A, the dripping is completed in 2.6h, and the dripping process is controlled The temperature of the reaction solution is 65-70°C; after the addition is completed, the temperature is raised, and the temperature of the reaction solution is controlled between 70-75°C and the temperature is kept for 0.5h; after the temperature is finished, 1.5g AIBME is added to the 12.5g dodecafluoroheptane methacrylate In the mixed liquid composed of ester and 15.0g vinyl trimethoxysilane, stir and mix until the AIBME is completely dissolved to fo...

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Abstract

The invention belongs to the technical field of high-molecular polymer preparation and specifically relates to a nontransparent polymer resin and an application thereof in a serum separation gel. In a heptane solvent system, styrene, acrylics and a silane coupling agent are taken as monomers, dimethyl azo diisobutyrate is taken as an initiator for initiating the polymerization for the polymer resin and then the polymer resin is taken as a raw material for preparing an end product of the serum separation gel. The serum separation gel prepared according to the invention is less in dosage of inorganic white carbon black powder, excellent in thixotropic property, high in stability of storage and contact between the product and the blood and excellent in irradiation resistance.

Description

Technical field [0001] The invention relates to the technical field of high molecular polymer preparation, in particular to a preparation method of an opaque polymer resin for serum separation, a serum separation gel with a specific gravity between serum and plasma and physiological inertness and a preparation method thereof. Background technique [0002] With the rapid development of laboratory medicine technology and the improvement of people’s pace of life, testing methods are becoming more and more automated, intelligent, and sophisticated. People have higher and higher requirements for the accuracy of test results, and require faster and faster test rates. Simple, safe, and convenient disposable vacuum blood collection containers have been widely promoted and applied. Therefore, how to quickly separate high-quality, pollution-free serum that does not affect the detection equipment is particularly important. People invented a separating gel for separating serum and plasma. As...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/18C08F212/08C08F220/24C08F230/08C08F4/04C08L33/08C08L71/02C08K3/36C08K5/12C08K5/5425B01D17/02
CPCB01D17/02C08F4/04C08F220/18C08F220/1804C08L43/04C08L71/02C08K3/36C08K5/12C08K5/5425C08F212/08C08F220/1808C08F220/24C08F230/08
Inventor 王中喜胡会弟王安琪
Owner 湖北新德晟材料科技有限公司
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