Livestock feed T-2 toxin compound adsorbent as well as preparation method and application thereof

A composite adsorption, livestock and poultry feed technology, applied in the field of livestock and poultry feed T-2 toxin composite adsorbent and its preparation, can solve the problems of ignoring the health protection effect of additives on the body, lack of animal nutrition, adsorption effect of mycotoxin adsorbent and clinical Difficult application effects and other problems, to achieve the effects of improving growth performance, promoting body health, and alleviating toxic effects

Inactive Publication Date: 2017-12-29

HUAZHONG AGRICULTURAL UNIVERSITY

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AI-Extracted Technical Summary

Problems solved by technology

Montmorillonite and activated carbon cause good adsorption and are widely used in mycotoxin detoxification agents, but because of their non-specific adsorption, it is easy to adsorb a large amount of other nutrients in the feed, which may cause nutritional deficiencies in animals; different sources and Activated carbon as a component has defects such as large differences in th...

Abstract

The invention discloses a livestock feed T-2 toxin compound adsorbent as well as a preparation method and an application thereof. The livestock feed T-2 toxin compound adsorbent is prepared from raw materials in percentage by weight as follows: 60%-65% of modified montmorillonite, 1.0%-1.5% of selenomethionine hydroxy analogs, 18%-21% of yeast cell wall polysaccharide, 10%-15% of modified activated carbon and 2.0%-3.0% of curcumin through uniform mixing. A proper dosage of detoxification agents synthesized according to the formula are added to daily ration of broilers, which proves that the adsorbent can effectively relieve the toxic effect caused by T-2 toxin, particularly can improve the growth performance of the broilers and promote body health as compared with existing commercially available adsorbents; a better effect can be obtained after a few adsorbent is added and the production cost is reduced.

Application Domain

Other chemical processesAccessory food factors

Technology Topic

Activated carbonLivestock +8

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Examples

Experimental program(5)

Example Embodiment

[0021] The preparation method of the above-mentioned livestock and poultry feed T-2 toxin composite adsorbent comprises the following steps:

[0022] 1) The modified activated carbon is obtained by placing the powdered activated carbon at a temperature of 1000-1200° C. for 3-5 hours with oxygen barrier heat treatment; the mesopore volume of the modified activated carbon is 0.570-0.685 cm 3 /g, the specific surface area is 1030~1078m 2 /g;

[0023] 2) will take by weighing modified montmorillonite, selenomethionine hydroxyl analog, yeast cell wall polysaccharide, modified activated carbon and curcumin according to the above-mentioned weight percentage, for subsequent use;

[0024] 3) Mixing the modified montmorillonite, selenomethionine hydroxyl analog, yeast cell wall polysaccharide, modified activated carbon and curcumin uniformly to obtain the T-2 toxin composite adsorbent for livestock and poultry feed.

[0025] Sources of the above raw materials:

[0026] The preparation method of modified montmorillonite:

[0027] 1) Pour 400g of commercially available calcium-based montmorillonite into 400mL of distilled water to prepare a slurry,

[0028] 2) Then add 6% NaF remodeling agent, take a water bath at about 70°C for 2h to make sodium montmorillonite, wash and dry;

[0029] 3) 0.5mol/L FeCl 3 The solution is mixed with the NaOH solution in a volume ratio of 1:1.5 to 2.5 to make a modifier;

[0030] 4) Mix the sodium montmorillonite and the modifier solution in a mass-volume ratio of 1:1.5-3.0g/ml, and shake at a constant temperature of 60°C for 10h. It was left standing for 10h, then filtered and dried, and activated at 110°C. Inorganic modified montmorillonite was obtained.

[0031] Selenomethionine hydroxy analogs, yeast cell wall polysaccharides, activated carbon and curcumin are commercially available.

[0032] A comparative experiment of adding the above-mentioned T-2 toxin composite adsorbents in livestock and poultry feeds

[0033] 1. The detoxification effect of the T-2 toxin composite adsorbent in livestock and poultry feed in the chick T-2 toxin poisoning model

[0034] 1.1 Animal experiment design and administration:

[0035] The experiment selected 120 healthy 1-day-old Cobb broilers with similar body weight and randomly divided them into 5 treatment groups with 4 replicates in each group and 6 birds in each replicate. Before the test, the chicken coop and chicken coop were thoroughly cleaned and fumigated. During the experimental period, the experimental diets were fed for 2 weeks, as shown in Table 1. Newcastle disease vaccine was administered on the first day of the experiment. The animals were kept in cages with free access to water and food, and the performance of the animals was observed daily.

[0036] Table 1 Test groups for the study on the detoxification effect of T-2 toxin composite adsorbent additive in broilers

[0037]

[0038] Remarks: See NRC 1994 for the formula of basal diet; the addition amount of T-2 toxin composite adsorbent and commercially available detoxification agent in livestock and poultry feed is 0.05%.

[0039] 1.2 Detection indicators:

[0040] 1.21 Determination of growth performance

[0041] At the beginning of the experiment and at the end of the experiment, the rats were weighed on an empty stomach in the morning. Morbidity and mortality throughout the trial were recorded. The daily feed intake per cage was recorded during the experiment. The feed intake and body weight of the broilers were measured on days 7 and 14 of the experiment for each treatment group, respectively, for the calculation of average feed intake, average weight gain and feed conversion ratio (FCR).

[0042] Feed conversion ratio (FCR) = feed intake / body weight gain

[0043] 1.22 Determination of blood biochemical indicators

[0044] On the 14th day of the experiment, serum tissues of 8 broilers in each group were collected for the determination of blood routine indexes.

[0045] Blood was collected in a 10 ml centrifuge tube, and after blood collection, it was left standing at room temperature for 2 hours, overnight at 4°C, and centrifuged the next day. The blood was centrifuged at 3000r/min for 10min, and the supernatant was taken into a 1.5ml EP tube and stored at -80°C. The samples were determined by automatic biochemical analyzer for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB) and other indicators.

[0046]1.23 Results:

[0047] After T-2 toxin is added to the diet, the daily weight gain of broiler feed intake and feed conversion efficiency are significantly decreased, and the toxicity effect is significant; after the adsorbent of the invention is added to the broiler diet contaminated with T-2 toxin, the T-2 toxin is significantly increased. -2 The feed intake and daily gain of toxin-poisoned broilers improved feed efficiency, and significantly reduced the content of aspartate aminotransferase (AST) in serum, indicating that it has a certain liver protection effect; and the adsorbent of the present invention is used in feed conversion. The rate is significantly better than the commercially available detoxifier B, which can reduce the cost of breeding. Adding the detoxifying agent of the present invention alone has no adverse effect on the growth performance of broilers.

[0048] Based on the above results, it shows that the T-2 toxin composite adsorbent for livestock and poultry feed of the present invention has a good alleviating effect on the decline of growth performance caused by T-2 toxin poisoning in broilers, and the effect is better than that of the commercial detoxification agent.

[0049] Table 3 The effect of adding detoxification agent and T-2 toxin in the diet on the growth performance of chicks (X±S)

[0050]

[0051]

[0052] Table 4 Effects of adding detoxifier and T-2 toxin in diets on blood biochemical indexes of 14-day-old broilers (X±S)

[0053]

Example Embodiment

[0054] Example 1

[0055] The preparation method of the above-mentioned livestock and poultry feed T-2 toxin composite adsorbent 1 comprises the following steps:

[0056] 1) The modified activated carbon is obtained by placing the powdered activated carbon at a temperature of 1100° C. for 4 hours with oxygen insulation and heat treatment; the mesopore volume of the modified activated carbon is 0.570-0.685 cm 3 /g, the specific surface area is 1030~1078m 2 /g;

[0057] 2) 62.0% of modified montmorillonite, 1.0% of selenomethionine, 20% of yeast cell wall polysaccharide, 15% of modified activated carbon and 2.0% of curcumin will be weighed according to the above-mentioned weight percentage, for subsequent use;

[0058] 3) Mixing the modified montmorillonite, selenomethionine hydroxyl analog, yeast cell wall polysaccharide, modified activated carbon and curcumin evenly;

Example Embodiment

[0059] Example 2

[0060] The method for preparing livestock and poultry feed T-2 toxin composite adsorbent 2 in the present embodiment is basically the same as the preparation method in the embodiment, and the difference lies in:

[0061] The raw materials of T-2 toxin composite adsorbent 2 in livestock and poultry feed are 65% modified montmorillonite, 1.0% selenomethionine hydroxy analog, 21% yeast cell wall polysaccharide, 10% modified activated carbon according to weight percentage. and 3.0% curcumin.

PUM

Property	Measurement	Unit
Mesopore volume	0.57 ~ 0.685	cm³/g
Specific surface area	1030.0 ~ 1078.0	m²/g

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Livestock feed T-2 toxin compound adsorbent as well as preparation method and application thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

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Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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