Freezing-drying method for live vaccine
A drying method, vacuum freeze-drying technology, applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve the problems of unstable quality, large loss of potency, high rejection rate, and achieve uniform sublimation rate. Effect
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Embodiment 1
[0030] A freeze-drying method of swine transmissible gastroenteritis and epidemic diarrhea virus dual live vaccine, including the following steps: two transmissible gastroenteritis (SCJY-1 strain) and epidemic diarrhea virus (SCSZ-1 strain) The seed virus solution is added to the seedling tank, the temperature in the tank is controlled at 10°C, the tank is stirred evenly, the heat-resistant protective agent is added, and the stirring is continued, and then divided into 10ml vials of 2.6ml each. While filling, the temperature of the slab is controlled at about 0℃; after filling, the machine will automatically half stopper, and then put the filling product into the pumping tray and send it into the freeze-drying box in time, close the door, and use 10 minutes Time to reduce the temperature of the layer fluid of the vacuum freeze dryer to -43℃, keep it for 5h, and then start vacuuming, when the vacuum degree reaches below 15Pa, start to heat up; when the partition temperature rises...
Embodiment 2
[0033] A freeze-drying method of swine transmissible gastroenteritis and epidemic diarrhea virus dual live vaccine, including the following steps: two transmissible gastroenteritis (SCJY-1 strain) and epidemic diarrhea virus (SCSZ-1 strain) The seed virus solution is added to the seedling tank, the temperature in the tank is controlled at 10°C, the tank is stirred evenly, the heat-resistant protective agent is added, and the stirring is continued, and then divided into 10ml vials of 2.6ml each. While filling, the temperature of the slab is controlled at about 0℃; after filling, the machine will automatically half stopper, and then put the filling product into the pumping tray and send it into the freeze-drying box in time, close the door, and use 10 minutes Time to reduce the temperature of the layer fluid of the vacuum freeze dryer to -23°C and keep it for 1.5h; cool the product at a rate of 1°C / h to -25°C; adjust the temperature in the vacuum freeze dryer to -43°C and keep it ...
Embodiment 3
[0036] A freeze-drying method of swine transmissible gastroenteritis and epidemic diarrhea virus dual live vaccine, including the following steps: two transmissible gastroenteritis (SCJY-1 strain) and epidemic diarrhea virus (SCSZ-1 strain) The virus solution is added to the seedling tank, the temperature in the tank is controlled at 10°C, the tank is stirred evenly, the heat-resistant protective agent is added, and the stirring is continued, and then divided into 10ml vials of 2.6ml each. While filling, the temperature of the slab is controlled at about 0℃; after filling, the machine will automatically half stopper, and then put the filling product into the pumping tray and send it to the freeze-drying box in time, close the door, and use 10 minutes Time to reduce the temperature of the layer fluid of the vacuum freeze dryer to -16°C and keep it for 2h; then cool the product at a rate of 1°C / h to -25°C; adjust the temperature in the vacuum freeze dryer to -43°C and keep it 3h,...
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