A kind of freeze-drying method of live vaccine

A drying method, vacuum freeze-drying technology, applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve the problems of unstable quality, large loss of potency, high rejection rate, and achieve uniform sublimation rate. Effect
CN107543373BActive Publication Date: 2019-04-26SICHUAN HUAPAI BIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN HUAPAI BIO PHARMA
Publication Date
2019-04-26

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Abstract

The invention discloses a freezing-drying method for live vaccine. The freezing-drying method comprises the steps that the eutectic point range of a to-be-frozen and to-be-dried vaccine is tested, then, the live vaccine is placed in a vacuum freezing-drying machine pre-cooled to 0+ / -1 DEG C, when the temperature of a plate layer of the vacuum freezing-drying machine is reduced to be higher than the eutectic point of the live vaccine by 1-2 DEG C, the current state is kept for 1-2 h, and continuous cooling is conducted with the rate of 1 DEG C / h till all vaccine is frozen; and cooling is immediately conducted to the temperature needed for sublimation, and finally vacuum sublimation is conducted according to the normal procedure. The product obtained through the method is not provided with large ice crystals, sublimation is easy, and after freezing-drying, a good product physical behavior can be obtained, and the freezing-drying titer losses are minimal.
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Description

technical field

[0001] The invention belongs to the technical field of cryoprotection of vaccines, and in particular relates to a freeze-drying method of live vaccines. Background technique

[0002] Porcine epidemic diarrhea and porcine transmissible gastroenteritis are widespread worldwide, especially in Asian countries such as Korea, Japan and China. Porcine epidemic diarrhea and porcine transmissible gastroenteritis can reduce the survival rate of pigs, poor uniformity, slow growth, reduce weight gain, delay the time to market, reduce feed utilization, increase additional consumption, and reduce their immunity. Increase the susceptibility to bacteria and virus, increase the incidence rate, make it dehydrated, shock and even die, etc., which have brought serious economic losses to the pig industry.

[0003] In order to effectively control porcine epidemic diarrhea and porcine transmissible gastroenteritis, my country has developed a dual live vaccine for the prevention an...

Claims

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