Microfluidic chip apparatus using polydimethylsiloxane as substrate material

Abstract

The present invention involves a micro -current -control chip device with polymailing siliconane as a substrate material, which belongs to the field of analysis and testing. There are some problems with cheap and easy -to -process polymailing siliconane, which are PDMS to make micro -current -controlled chips. The main point of this case is that the substrate material is PDMS with the original ecological surface. The chip's pipes are filled with doped micron -grade titanium dioxide particles; this titanium dioxide particles can induce the super -hydrophilic titanium dioxide through pre -visible light to induce its super hydrophilic properties Granules; the collection of the super -intimate channel between the particles between the titanium titanium dioxide particles, compensation and surpassing the original intensive hydrophobic pipeline, thereby achieved a constant and super -affordable modification effect; The ultrasonic waves induced the differences in the tension of the interface at both ends at the end of the chip, thereby guiding the sample fluid flowing along the pipe of the chip to flow towards the terminal direction.

Description

technical field [0001] The invention relates to a microfluidic chip device using polydimethylsiloxane as a substrate material, belonging to the field of analysis and testing. Background technique [0002] For the overall overview of microfluidic technology itself, you can refer to the monograph "Illustrated Microfluidic Chip Laboratory" published by the famous microfluidic expert Mr. Lin Bingcheng not long ago, which has been published by Science Press. The past, present, and future prospects of fluidic technology, etc., all have detailed and long-form expositions that go deep into specific details. [0003] The fields where microfluidic chips are often applied include various analysis and detection of sample solutions containing biomacromolecules. [0004] The basic structure of a microfluidic chip includes a substrate etched with channels and a cover sheet attached to it. The liquid flow channels on the substrate are apparently some The channel is not really closed to fo...

AI Technical Summary

Problems solved by technology

[0006] But it's not that simple

[0007] First, this polydimethylsiloxane material, which is referred to by the acronym PDMS, is itself a strongly hydrophobic material, and channels are built on this material. modification operation, then, after the overall assembly is completed, that is, after the cover is covered, because the inner surface of the channel in the structure occupies most of the inner surface of the liquid flow channel, then the inner surface of the PDMS channel is The strong hydrophobicity is the decisive factor, it will make it very difficult for the polar liquid fine flow similar to the aqueous solution to pass through, and its flow resistance is so large that even the general micropump is difficult to push, of course, if the cover sheet is also If you choose to use the PDMS material, then the problems are basically the same, with minor differences; therefore, in the prior art, it is necessary to modify and modify the inner surface of the channel on the PDMS material; then, this is for the PDMS channel Is the modification operation of the inner surface of the channel very troublesome? That's not the problem. What constitutes a serious technical problem is another problem: the PDMS polymer molecules in the bulk phase of the PDMS material substrate have the characteristics of automatic diffusion and migration to the surface. The characteristics of polymer molecules diffusing and migrating to the surface automatically will make the modified state of the inner surface of the channel modified by the surface unable to maintain for a long enough time. The maintenance time of the internal surface state is roughly only enough to complete the time required for the internal test experiment in the laboratory; in other words, the surface state of the PDMS channel inner surface after surface modification or surface modification is formed after modification It cannot last for a long time, but it will automatically tend to or change back to the surface state before the surface modification, and return to the original strongly hydrophobic surface state in a short period of time. Then, just imagine, such a slight Can flow control chips be produced in large quantities, stored in large quantities, and widely promoted? The answer is obvious, that is, impossible

This problem has also existed for many years, and so far, it has not been properly solved

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