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Pharmaceutical composition or functional health food for preventing and treating metabolic diseases, containing water extract of pleurotus eryngii var. ferulae (pf.) as active ingredient

A technology for metabolic diseases and functional foods, which is applied in the field of pharmaceutical compositions for the prevention and treatment of metabolic diseases or healthy functional foods containing water extract of Asafoetida as an active ingredient, and can solve the problems of unpublished and other problems.

Inactive Publication Date: 2018-01-19
庆尚北道 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] On the other hand, although Korean Laid-Open Patent No. 10-2012-0143701 (divisional application No. 10-2015-0055605) discloses a water extract containing Ferulae ferulae as an active ingredient for the prevention and treatment of hyperlipidemia composition, but the inventors of the present invention conducted repeated studies on the above-mentioned Ferula ferulae water extract, and as a result, it was confirmed that the extract has another effect of inhibiting fat accumulation and blood sugar increase that occurs when high-fat food is ingested, thereby completing the present invention, but the above-mentioned contents have not been disclosed so far

Method used

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  • Pharmaceutical composition or functional health food for preventing and treating metabolic diseases, containing water extract of pleurotus eryngii var. ferulae (pf.) as active ingredient
  • Pharmaceutical composition or functional health food for preventing and treating metabolic diseases, containing water extract of pleurotus eryngii var. ferulae (pf.) as active ingredient
  • Pharmaceutical composition or functional health food for preventing and treating metabolic diseases, containing water extract of pleurotus eryngii var. ferulae (pf.) as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1. Preparation of an aqueous extract of Ferulae ferulae

[0044] Purchase dried ferulae mushrooms (Pleurotus eryngii var.ferulea (Pf.)) from the market, put them into a coarse powder, put them into a gauze bag, and mix 50mL of water as an extraction solvent for every 1g of powder, and then mix them with 50mL of water at 37 Extract in a shaker incubator for 24 hours at ° C. Centrifuge the supernatant in the shaker incubator at 2500 rpm for 10 minutes, collect the supernatant after filtration, and use it as the test material described below.

Embodiment 2

[0045] Example 2. Anti-obesity and anti-diabetic efficacy experiments of the water extract of Ferula ferulae

[0046] In order to confirm the anti-obesity and anti-diabetic effects of Ferula ferulae water extract, experimental animals were used to measure body weight gain, adipose tissue weight, morphological changes of fat and liver tissue, and blood sugar content.

Embodiment 2-1

[0047] Example 2-1: Experimental animals and feed

[0048] As far as experimental animals are concerned, 8-week-old male mice of C57BL / 6 line were adapted to solid diet for 1 week in the Experimental Animal Center of Pohang University of Science and Technology, and mice with an average body weight of 25 g were selected according to randomized block design. They were divided into 3 groups, 6 in each group, and fed for 8 weeks. The experimental groups were divided into normal diet group (NCD), high-fat diet group (HFD), and a group ingesting high-fat diet and water extract of Ferula ferulae together (HFD+PEF). The normal feed group was supplied with a normal feed containing 10% of the total calories in fat, the high-fat feed group was fed with a feed containing 60% of the total calories in fat, and the group that ingested the high-fat feed together with the water extract of feruli was supplied with 8% by weight. The high-fat feed of the water extract of Ferula ferulae, water an...

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Abstract

The invention relates to a composition for preventing and treating metabolic diseases, containing a water extract of Pleurotus eryngii var. ferulae (Pf.) as an active ingredient, wherein the water extract of Pleurotus eryngii var. ferulae (Pf.) has a remarkable effect of being able to be used as a pharmaceutical composition or functional health food for preventing or treating obesity or diabetes by confirming the functionality whereby fat accumulation and blood glucose increase generated when taking a high fat diet can be inhibited.

Description

technical field [0001] The present invention relates to a composition for the prevention and treatment of metabolic diseases or a health functional food containing an aqueous extract of ferulae ferulae as an active ingredient. A pharmaceutical composition for metabolic diseases such as obesity and diabetes, or a health functional food, the above-mentioned water extract of ferulae ferulae has inhibitory effect on fat accumulation and blood sugar increase that occur when high-fat food is ingested. Background technique [0002] In recent years, the standard of living has improved along with economic development, so people can enjoy a rich dietary life, but changes in the diet, mainly meat, lead to excessive calorie intake. This change in the diet of modern people shows a trend of rapid increase in the obese population due to severe lack of exercise, etc. resulting in less calorie consumption. It is reported that obesity not only causes appearance problems, but also causes vari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61K9/20A61K9/48A23L33/105A61P3/04A61P3/10
CPCA61K9/0019A61K9/0095A61K9/08A61K9/1611A61K9/1623A61K9/2013A61K9/2018A61K9/2059A61K9/4858A61K9/4866A61K36/07A61K47/02A61K47/26A61K2236/331A23L33/105A61P3/04A61P3/10A23V2002/00A61K9/0056A23L31/00A23L33/10
Inventor 柳成浩金载旺金钟仁金载允金英美崔荣祐赵镜珍金旭东沈相甲千于宰南宗赫
Owner 庆尚北道
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