Method using mulberry silk to prepare viscose silk fibroin hydrogel

Abstract

The invention discloses a method using mulberry silk to prepare viscose silk fibroin hydrogel. The method mainly includes: selecting mulberry silk fibroin which is good in biocompatibility and wide insource to serve as the base material, using polyethylene glycol as the auxiliary material, and adjusting the pH of a mixed solution to prepare the novel gel with certain viscosity. The novel gel is used for soft tissue injection filling. The method has the advantages that the method is simple to operate, does not need precious equipment and is high in biosafety; the prepared fibroin gel can be easily retained in a body and is less prone to loss, injection filling times can be reduced, resource waste and patient economic burden are reduced, a new application field of fibroin materials is developed, and considerable social and economic benefits are achieved.

Description

technical field

[0001] The invention relates to a method for preparing viscous silk fibroin hydrogel, in particular to a method for preparing viscous silk fibroin hydrogel by using mulberry silk, and belongs to the field of soft tissue engineering. Background technique

[0002] In recent years, injectable gels for microplastic surgery have developed rapidly. Among them, sodium hyaluronate is widely used because of its good biocompatibility and immunogenicity. However, sodium hyaluronate gels improved by cross-linking Glue can only last for 3-6 months in the human body. Repeated injections are required to maintain the effect of micro-plastic surgery, which increases safety risks, patient pain and economic burden. Clinical needs are biodegradable and viscoelastic. Effective shaping soft tissue filler.

[0003] Mulberry silk is a natural polymer material with excellent biocompatibility. Silk fibroin obtained from degumming of mulberry silk is a fibrous protein. Silk fibroin ...

Images