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Response type medical gel as well as preparation method and application thereof

A gel, gelatin technology, applied in the field of medical devices, can solve problems such as wound infection, new tissue damage, delayed healing and even complications

Active Publication Date: 2018-01-26
HANGZHOU YAHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, skin wound dressings need to be replaced regularly. For large-area wounds, the replacement will still cause certain damage to the new tissue, causing wound infection, delayed healing and even complications. The adhesiveness of the gel when changing the dressing should be reduced as much as possible. Reducing secondary damage has become a top priority

Method used

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  • Response type medical gel as well as preparation method and application thereof
  • Response type medical gel as well as preparation method and application thereof
  • Response type medical gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]The hyperbranched polymer monomer HB-PBAE (such as figure 1 shown). In the reaction, the molar ratio of the active hydrogen of the amino group to the carbon-carbon double bond is 1.2:1, in which PETA and PEGDA700 each provide half of the carbon-carbon double bond.

[0036] The specific operation steps are: Weigh 6.6 grams of dopamine hydrochloride (DOPA•HCl), 6 grams of PETA, 21 grams of PEGDA700 and 80 grams of DMSO solvent, mix thoroughly; add triethylamine (TEA) dropwise to adjust the pH value of the mixture About 8; the mixture was heated in an oil bath, the reaction time was 2.5 h, and the temperature was set at 80°C. Since dopamine is easily oxidized under light, the oil bath device needs to be protected from light; Methyl tert-butyl ether for purification. After the purification once, use a cotton-stuffed funnel to filter out the precipitated unreacted DOPA·HCl, and then purify the filtrate twice with methyl tert-butyl ether; Steam to remove the residual purifyi...

Embodiment 2

[0038] Using 1-vinylimidazole (VI) as raw material, tetraethylthiuram disulfide (DS) as chain transfer agent and azobisisobutyronitrile (AIBN) as initiator, polyvinylimidazole was synthesized by RAFT method. The molar ratio of DS, AIBN and 1-vinylimidazole in the reaction is 1:2:50.

[0039] The specific operation steps are as follows: fully mix 23.53 g of VI, 1.48 g of DS, 1.64 g of AIBN and 100 ml of DMF solvent; pass nitrogen gas into the mixture for at least 30 min, and exhaust the air; heat in an oil bath, and the reaction time is 6 h. The temperature was set at 70°C; after the reaction, the reaction solution was naturally cooled to room temperature; the reaction solution was purified twice with 1000 ml of glacial ether, and then placed in a vacuum drying oven to volatilize the remaining purifying agent, anhydrous ether, to obtain a yellow-brown solid The product, namely PVI.

Embodiment 3

[0041] Dissolve 30 mg of gelatin in 100 μL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 2% (w / v); add HP-PBAE and PVI solutions to the above gelatin aqueous solution sequentially Mix well at room temperature to obtain an aqueous solution of the HP-PBAE / Geln / PVI mixture, and HP-PBAE / Geln / PVI in the aqueous solution of the mixture. Among them, the final concentration of HP-PBAE polymer monomer is 5% (w / v), and the final concentration of PVI is 2.5% (w / v); add ferric chloride solution to the aqueous solution of HP-PBAE / Geln / PVI mixture, quickly Vortex to obtain the gel precursor solution, the added ferric chloride solution concentration is 100mM, the volume of the added ferric chloride solution is 20% of the aqueous solution volume of the HP-PBAE / Geln / PVI mixture; the gel precursor solution Inhale the syringe with the needle removed and expel it quickly and evenly as a gel.

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Abstract

The invention provides response type medical gel. Particularly, a functional hyperbranched polymer monomer (HB-PBAE) is synthesized by virtue of Michael addition reaction of dopamine (DOPA), polyethylene glycol diacrylate (PEGDA700) and pentaerythritol triacrylate (PETA); and gel is formed by virtue of a mixed solution of HB-PBAE, polyvinyl imidazol (PVI) and gelatin (Geln) under the action of aniron ion (Fe<3+> solution). The gel has the properties of softness and viscidity in the primary formation period, and the viscidity is obviously reduced after the gel is soaked in a zinc ion (Zn<2+> solution). Hydrogel provided by the invention has syringeability, can be taken as a sealing agent or a wound surface dressing for surgical operations and is used for smearing the wound surface of a tissue, so that the adverse leakage of liquid or gas is avoided; and the viscidity of the gel has ion responsitivity, so that the secondary injury in a dressing change process can be reduced, and the pain of the wound surface can be alleviated.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a responsive medical gel and its preparation method and application. Background technique [0002] Polymer hydrogels can be defined as cross-linked polymers that can swell in water and retain a large amount of water without being dissolved. According to the different bonding mechanisms of cross-linked networks, hydrogels can be divided into physical gels and chemical gels. Physical gels are gels formed by physical interactions such as electrostatic interactions, hydrogen bonds, and chain entanglements. This kind of gel is non-permanent, and by heating, the gel can be converted into a sol, so it is also called a thermoreversible gel. Chemical gel is a polymer with a three-dimensional network structure formed by cross-linking chemical bonds. It is permanent and is also called true gel. Injectable gel is a new type of hydrogel that has emerged in recent years. The gel precursor with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/04A61L31/06A61L31/02A61L24/00A61L24/10A61L24/04A61L24/06A61L24/02A61L26/00C08G83/00
Inventor 王玮丁洁李丹汪伟朱家喜祝文斌林高品
Owner HANGZHOU YAHUI BIOTECH CO LTD
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