A kind of responsive medical gel and its preparation method and application

A gel and gelatin technology, applied in the field of medical devices, can solve problems such as wound infection, delayed healing, even complications, and new tissue damage

Active Publication Date: 2021-11-16
HANGZHOU YAHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, skin wound dressings need to be replaced regularly. For large-area wounds, the replacement will still cause certain damage to the new tissue, causing wound infection, delayed healing and even complications. The adhesiveness of the gel when changing the dressing should be reduced as much as possible. Reducing secondary damage has become a top priority

Method used

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  • A kind of responsive medical gel and its preparation method and application
  • A kind of responsive medical gel and its preparation method and application
  • A kind of responsive medical gel and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0035]The hyperbranched polymer monomer HB-PBAE (such as figure 1 shown). In the reaction, the molar ratio of the active hydrogen of the amino group to the carbon-carbon double bond is 1.2:1, in which PETA and PEGDA700 each provide half of the carbon-carbon double bond.

[0036] The specific operation steps are: Weigh 6.6 grams of dopamine hydrochloride (DOPA•HCl), 6 grams of PETA, 21 grams of PEGDA700 and 80 grams of DMSO solvent, mix thoroughly; add triethylamine (TEA) dropwise to adjust the pH value of the mixture About 8; the mixture was heated in an oil bath, the reaction time was 2.5 h, and the temperature was set at 80°C. Since dopamine is easily oxidized under light, the oil bath device needs to be protected from light; Methyl tert-butyl ether for purification. After the purification once, use a cotton-stuffed funnel to filter out the precipitated unreacted DOPA·HCl, and then purify the filtrate twice with methyl tert-butyl ether; Steam to remove the residual purifyi...

Embodiment 2

[0038] Using 1-vinylimidazole (VI) as raw material, tetraethylthiuram disulfide (DS) as chain transfer agent and azobisisobutyronitrile (AIBN) as initiator, polyvinylimidazole was synthesized by RAFT method. The molar ratio of DS, AIBN and 1-vinylimidazole in the reaction is 1:2:50.

[0039] The specific operation steps are as follows: fully mix 23.53 g of VI, 1.48 g of DS, 1.64 g of AIBN and 100 ml of DMF solvent; pass nitrogen gas into the mixture for at least 30 min, and exhaust the air; heat in an oil bath, and the reaction time is 6 h. The temperature was set at 70°C; after the reaction, the reaction solution was naturally cooled to room temperature; the reaction solution was purified twice with 1000 ml of glacial ether, and then placed in a vacuum drying oven to volatilize the remaining purifying agent, anhydrous ether, to obtain a yellow-brown solid The product, namely PVI.

Embodiment 3

[0041] Dissolve 30 mg of gelatin in 100 μL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 2% (w / v); add HP-PBAE and PVI solutions to the above gelatin aqueous solution sequentially Mix well at room temperature to obtain an aqueous solution of the HP-PBAE / Geln / PVI mixture, and HP-PBAE / Geln / PVI in the aqueous solution of the mixture. Among them, the final concentration of HP-PBAE polymer monomer is 5% (w / v), and the final concentration of PVI is 2.5% (w / v); add ferric chloride solution to the aqueous solution of HP-PBAE / Geln / PVI mixture, quickly Vortex to obtain the gel precursor solution, the added ferric chloride solution concentration is 100mM, the volume of the added ferric chloride solution is 20% of the aqueous solution volume of the HP-PBAE / Geln / PVI mixture; the gel precursor solution Inhale the syringe with the needle removed and expel it quickly and evenly as a gel.

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Abstract

The invention provides a responsive medical gel. Specifically, a functionalized hyperbranched polymer monomer (HB‑PBAE) was synthesized by Michael addition reaction between dopamine (DOPA), polyethylene glycol diacrylate (PEGDA700) and pentaerythritol triacrylate (PETA); HB ‑PBAE, polyvinylimidazole (PVI) and gelatin (Geln) mixed solution in iron ion (Fe 3+ ) solution to form a gel. The initial stage of gel formation is soft and viscous, and zinc ions (Zn 2+ ) The gel adhesion decreased significantly after soaking in the solution. The hydrogel of the present invention has injectability, can be used as a surgical sealant or wound dressing, and can be applied on tissue wounds to avoid unfavorable liquid or gas leakage, and the gel adhesion property has ion responsiveness, which can reduce the time for changing dressings Secondary injury and reduce wound pain.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a responsive medical gel and its preparation method and application. Background technique [0002] Polymer hydrogels can be defined as cross-linked polymers that can swell in water and retain a large amount of water without being dissolved. According to the different bonding mechanisms of cross-linked networks, hydrogels can be divided into physical gels and chemical gels. Physical gels are gels formed by physical interactions such as electrostatic interactions, hydrogen bonds, and chain entanglements. This kind of gel is non-permanent, and by heating, the gel can be converted into a sol, so it is also called a thermoreversible gel. Chemical gel is a polymer with a three-dimensional network structure formed by cross-linking chemical bonds. It is permanent and is also called true gel. Injectable gel is a new type of hydrogel that has emerged in recent years. The gel precursor with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/04A61L31/06A61L31/02A61L24/00A61L24/10A61L24/04A61L24/06A61L24/02A61L26/00C08G83/00
Inventor 王玮丁洁李丹汪伟朱家喜祝文斌林高品
Owner HANGZHOU YAHUI BIOTECH CO LTD
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