Fluorescent probe for visual detection of Cu<2+> as well as preparation method and application of fluorescent probe

A fluorescent probe, copper ion technology, applied in the field of analytical chemistry, can solve the problems of high skilled technicians, not ideal detection methods, complex instruments, etc., to achieve good water solubility, excellent optical performance, high selectivity and sensitivity. Effect

Inactive Publication Date: 2018-01-26
HEZHOU UNIV
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing determination of Cu 2+ The most common methods are atomic absorption spectrometry and spectrophotometry, but the former requires complex instruments, skilled technicians and high detection costs, while the latter requires cumbersome operations, so it is not an ideal Cu 2+ Detection method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe
  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe
  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A fluorescent probe for visually detecting copper ions of the present invention is 2-(4-pyridinecarboxylate styryl)-1,3,3-trimethyl-3H-indole iodide salt, and the molecular formula is C 25 h 23 IN 2 o 2 , the structural formula is shown in formula (1):

[0044]

[0045] The above-mentioned preparation method of the fluorescent probe for visually detecting copper ions of the present invention, its synthetic route is as follows: figure 1 shown, including the following steps:

[0046] (1) synthetic compound 4-pyridinecarboxylate benzaldehyde, structural formula such as formula (2):

[0047]

[0048] The reaction formula is as formula (3):

[0049]

[0050] The specific process is: dissolve 4-hydroxybenzaldehyde (1.95g, 16mmol) in anhydrous dichloromethane, then add 2-pyridinecarboxylic acid (2.44g, 20mmol), 1-ethyl-3-(3-dimethylamino Propyl) carbodiimide hydrochloride (EDCI, 3.83g, 20mmol) and 4-dimethylaminopyridine (DMAP, 0.73g, 6mmol), the resulting mixed...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a fluorescent probe for visual detection of Cu<2+> as well as a preparation method and an application of the fluorescent probe. The fluorescent probe is 2-(4-picolinate styryl)-1,3,3-trimethyl-3H-indole iodide, and the structural formula is shown as formula (I) in the description. The preparation method comprises the following steps: (a) 4-picolinate benzaldehyde is prepared from p-hydroxybenzaldehyde and 2-picolinic acid through an esterification reaction; (b) the compound shown as the formula (I) is prepared from 4-picolinate benzaldehyde and 1 ,2 ,3 ,3-tetramethyl-3H-indole iodide through a condensation reaction. The fluorescent probe for visual detection of Cu<2+> has the advantages of high sensitivity, good selectivity, short response time and the like.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a fluorescent probe for visually detecting copper ions, a preparation method and application thereof. Background technique [0002] Copper ions (Cu 2+ ) is the third most abundant element in the human body and plays an important role in various basic physiological processes of the organism. However, Cu in cells 2+ Changes in the concentration of methionine can lead to various diseases, including Alzheimer's disease, Mainck's syndrome, hepatolenticular degeneration, and even cancer. In addition, Cu 2+ It is widely used in industry and agriculture, so it is also a serious environmental pollutant. Therefore, looking for a simple and fast detection method for Cu 2+ Analytical testing is of great significance. Existing determination of Cu 2+ The most common methods are atomic absorption spectrometry and spectrophotometry, but the former requires complex...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/12C09K11/06G01N21/64G01N21/78
Inventor 朱东建梁宁段振华任爱山唐利余倍奇陈海霞蔡毓玮蔡文
Owner HEZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap