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A kind of hplc fingerprint spectrum determination method of standard decoction of jade female decoction

A standard fingerprint and fingerprint technology, which is applied in the field of HPLC fingerprint determination of Yunvjian standard soup, can solve the problems of lack of quality control, reduce the possibility of manual processing, ensure curative effect, and achieve high precision effects

Active Publication Date: 2020-06-16
天津同仁堂集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the standard granules of Yunv decoction are studied on the basis of the standard decoction from extraction to granulation, but in order to produce granules that are highly consistent with traditional decoctions in terms of efficacy and quality, there is a lack of an effective means to control them. pellets for quality control

Method used

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  • A kind of hplc fingerprint spectrum determination method of standard decoction of jade female decoction
  • A kind of hplc fingerprint spectrum determination method of standard decoction of jade female decoction
  • A kind of hplc fingerprint spectrum determination method of standard decoction of jade female decoction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1 The HPLC Fingerprint Determination Method of Yunu Decoction Standard Decoction

[0072] 1.1 Instruments and reagents

[0073] instrument:

[0074]

[0075]

[0076] Reagent:

[0077]

[0078] Control substance:

[0079]

[0080] 1.2 Sample preparation:

[0081] 1.2.1 Preparation of samples and sample solutions for testing

[0082] (1) Sample preparation: take different origins and different batches of medicinal materials or decoction pieces that have passed the inspection of the Chinese Pharmacopoeia, weigh 15g of raw gypsum, 15g of rehmannia glutinosa, 6g of Radix Ophiopogon japonicus, 4.5g of Zhimu, 4.5g of Achyranthes bidentata, add 300mL Soak in deionized water for 60 minutes, boil with strong fire (220V) for 10 minutes, decoct with slow fire (140V) for 35 minutes (the amount of decoction is about 140mL), pour it while it is hot, and make the standard soup of Yunujian.

[0083] (2) Preparation of the test sample solution: Take 5 mL of the ...

Embodiment 2

[0193] Example 2 The quality control method of standard granules of Yunu decoction

[0194] A kind of quality control method of standard granule of jade female decoction, comprises the following steps:

[0195] (1) According to the method in 1.2.1 (1) in Example 1, prepare the Jade Girl Fried Standard Soup, adopt the assay method in Example 1 to set up the standard fingerprint of the Jade Girl Fried Standard Soup;

[0196] (2) Get the standard granules of Yunujian to be checked, and obtain fingerprints according to the assay method in Example 1;

[0197] (3) Compare the fingerprints obtained in step (2) with the standard fingerprints obtained in step (1), if they meet, they are qualified products, and if they do not meet, they are unqualified products.

[0198] Preparation of the test sample solution of the standard granules of Yunujian: take the standard granules of Yunujian under the difference in filling volume, mix them evenly, grind them finely, take 1.5g, accurately wei...

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Abstract

The invention provides an HPLC (high-performance liquid chromatography) fingerprint spectrum measurement method for a standard Yunujian decoction, and belongs to the technical field of traditional Chinese medicine. The HPLC fingerprint spectrum measurement method includes (1), preparing a sample solution for test; (2), preparing a mixed reference substance solution; (4), accurately sucking the sample solution for test and the mixed reference substance solution, and injecting the solutions into a high-performance liquid chromatograph for measurement to acquire liquid chromatograms of the samplesolution for test and the mixed reference substance solution; (5), matching data of the liquid chromatograms of the sample solution for test and the mixed reference substance solution by traditionalChinese medicinal chromatography fingerprint spectrum similarity evaluation system software made by Chinese Pharmacopeia Commission to acquire a standard fingerprint spectrum. The HPLC fingerprint spectrum measurement method for the standard Yunujian decoction has the advantages that quality of standard Yunujian particles is controlled effectively, curative effect of the medicine is guaranteed, and the classic prescription is enabled to be under standard quality control.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an HPLC fingerprint determination method of Yunvjian Standard Decoction. Background technique [0002] As the main dosage form of traditional Chinese medicine clinical medicine, decoction of classic prescriptions of traditional Chinese medicine has the advantages of reasonable composition, definite curative effect, easy absorption, and quick onset of effect, and is deeply trusted by patients. However, due to the shortcomings of deployment, carrying, temporary decoction, and long-term storage, it is prone to mildew and deterioration, the soup tastes bitter and the volume is large, and the standard is difficult to unify, which seriously affects its clinical efficacy. It cannot adapt to the living requirements of modern people. In order to maintain the advantages of the decoction and overcome the various deficiencies of the decoction, under the strong support o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 张彦森高桂琴
Owner 天津同仁堂集团股份有限公司
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