Febuxostat composition

A technology of febuxostat and a composition, which is applied in the field of febuxostat composition and its preparation, can solve the problems of elevated total bilirubin, liver damage and the like, and achieves the advantages of reducing side effects, ensuring dissolution and changing characteristics Effect

Active Publication Date: 2018-02-02
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is an anti-ventilation drug with good clinical effect in recent years, but long-term use will cause certain damage to the liver, which is manifested in the increase of total bilirubin and alanine aminotransferase

Method used

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  • Febuxostat composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1, febuxostat 10g, glucosamine 240g, hydroxypropyl-β-cyclodextrin 10g, lactose 10g, microcrystalline cellulose 10g, povidone k30 1mg, sodium lauryl sulfate 1g, stearin Magnesium acid 4g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0031] Example 2, febuxostat 40g, glucosamine 600g, hydroxypropyl-β-cyclodextrin 30g, lactose 30g, microcrystalline cellulose 30g, povidone k30 2mg, sodium lauryl sulfate 3g, stearin Magnesium acid 8g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0032] Embodiment 3, febuxostat 10g, glucosamine 240g. Hydroxypropyl-β-cyclodextrin 20g, lactose 15g, microcrystalline cellulose 15g, povidone k30 12g, sodium lauryl sulfate 1.5g, magnesium stearate 4.5g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to a febuxostat composition and a preparation method thereof, and belongs to the technical field of medicines. Every unit dosage of the febuxostat composition contains 10-40 mg of febuxostat and 240-600 mg of glucosamine. Reasonable compatibility reduces the side effects of the febuxostat on the basis of guaranteeing the curative effects; and the reasonable preparation methodchanges the characteristics of a febuxostat tablet, and obtains a moisture resisting and absorbing stable tablet while guaranteeing the dissolution rate.

Description

technical field [0001] The invention relates to a febuxostat composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Gout is a disease caused by metabolic system dysfunction, and one of the notable signs is increased uric acid. In recent years, with the improvement of the quality of life, the number and incidence of gout patients have gradually increased. Especially for middle-aged and elderly people, this is already a relatively common metabolic disease. Affected joints will be swollen, stiff, and deformed, like stones, asymmetrical, and inconsistent in size. It is more common in places such as ear contours, toes, and fingers. Patients suffer from abnormal pain, and severe cases have limited mobility. Ventilated patients require long-term medication. [0003] Febuxostat is a xanthine oxidase (XO) inhibitor indicated for the long-term treatment of hyperuricemia with gout symptoms. It is an anti-ventilatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/426A61K31/7008A61K9/20A61K9/48A61K47/36A61P19/06A61P19/02
CPCA61K9/205A61K9/4866A61K31/426A61K31/7008A61K2300/00
Inventor 王海付玉麦李晓飞杨豪伟
Owner DISHA PHARMA GRP
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