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Device for simulating bone mineral loss and application method thereof

A bone mineral and bone tissue technology, applied in the field of space science research, can solve problems affecting cell function, reduction, cytoskeleton rearrangement, etc., and achieve the effect of simple method, simple structure, and uniform monitoring results

Pending Publication Date: 2018-02-06
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that simulated microgravity conditions can reduce the expression of force-sensitive genes COX2, PGE2, and Cbfa1 in osteoblasts, and regulate the differentiation of osteoblasts by affecting the expression of cytokines VD3, BMP2, and TGF-β; simulated microgravity can also lead to osteoblast differentiation. Skeletal rearrangements and affect cell function

Method used

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  • Device for simulating bone mineral loss and application method thereof
  • Device for simulating bone mineral loss and application method thereof

Examples

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Embodiment

[0036] Taking 0.01M dilute hydrochloric acid solution and the real-time monitoring of bone calcium loss in bovine bone tissue as examples, the specific implementation process is as follows:

[0037] ⑴Preparation of bone tissue samples: Take a section of adult bovine tibia, cut off both ends with a chainsaw, keep the flat part in the middle, boil in boiling water for 10-20 minutes, remove the fat and bone marrow in the bone, wash it, and dry it in the air 40~56h. A section of bone tissue with a length of 4-6 cm was taken from the middle of the dried bovine bone with a hand-held electric saw, and the bone tissue sample was obtained after grinding and smoothing.

[0038] (2) Fix the bone tissue sample at the bottom of a cylindrical plexiglass container 1 with radius (R)×height (H)=4cm×8cm.

[0039] (3) Prepare 0.01M dilute hydrochloric acid solution.

[0040] (4) Fill the plexiglass container 1 with the dilute hydrochloric acid solution, soak the bone tissue sample in the dilut...

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Abstract

The invention relates to a device for simulating bone mineral loss. The device comprises a cylindrical organic glass container and a computer, wherein the top of the cylindrical organic glass container is provided with a cover, and the bottom is provided with a slotted hole I; the cover is provided with a slotted hole II and a slotted hole III; a calcium ion concentration detector is inserted intothe slotted hole II; an in-vitro bone tissue sample fixed at the bottom and a simulated solution for soaking the sample are fixedly loaded in the organic glass container; the organic glass containeris connected with a peristaltic pump through a conduit I and the slotted hole III, and is connected with the peristaltic pump through a conduit II and the slotted hole I; a tail data line of the calcium ion concentration detector is connected with a USB (Universal Serial Bus) interface of the computer through a detector data acquisition unit; software matched with the calcium ion concentration detector is installed in the computer. The invention further discloses an application method for the device. The device is simple in structure, the method is simple and convenient, and obtained data areuniform and reliable; the device can be applied to monitoring and researching of bone mineral loss under a simulated space environment on the ground.

Description

technical field [0001] The invention relates to the technical field of space science research, in particular to a device for simulating bone mineral loss and its application method. Background technique [0002] Scientists from the former Soviet Union and the United States have determined from the space flight research in the past few decades that the space environment can cause the symptoms of osteoporosis in astronauts. The rate of mass loss is greater than the rate of bone reconstruction. In recent years, my country's space science research has developed very rapidly. Since the "Shenzhou 5" spacecraft successfully realized manned spaceflight, deep space exploration programs such as the moon landing project, the space station plan, and Mars exploration are steadily advancing. The future space flight will be even more Frequently, the time spent in space will be longer. Research data show that the bone weight loss of astronauts during spaceflight accounts for 1.5%~2% of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N23/22G01N23/20
CPCG01N1/28G01N23/20G01N23/22
Inventor 王菊芳李贺华君瑞张亚楠
Owner INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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